Search Results - "Karpenko, I. L."

Production and Study of Immunochemical Properties of Stabilized Env Trimer of Recombinant Form CRF63_02A6 of HIV-1 by Rudometova, N. B., Rudometov, A. P., Fando, A. A., Ushkalenko, N. D., Shcherbakov, D. N., Karpenko, L. I.

“…Stabilized trimers of the HIV-1 envelope glycoprotein Env are capable of inducing a potent and sustained broadly neutralizing antibody response in laboratory…”
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Removal of Double-Stranded RNA Contaminants During Template-Directed Synthesis of mRNA by Sharabrin, S. V., Bondar, A. A., Starostina, E. V., Kisakov, D. N., Kisakova, L. A., Zadorozhny, A. M., Rudometov, A. P., Ilyichev, A. A., Karpenko, L. I.

“…The removal of double-stranded RNA (dsRNA) contaminants during in vitro mRNA synthesis is one of the technological problems to be solved. Apparently, these…”
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Delivery of Experimental mRNA Vaccine Encoding the RBD of SARS-CoV-2 by Jet Injection by Kisakov, D. N., Kisakova, L. A., Sharabrin, S. V., Yakovlev, V. A., Tigeeva, E. V., Borgoyakova, M. B., Starostina, E. V., Zaikovskaya, A. V., Rudometov, A. P., Rudometova, N. B., Karpenko, L. I., Ilyichev, A. A.

“…We studied a needle-free jet injection delivery of an experimental mRNA vaccine encoding the receptor-binding domain of the SARS-CoV-2 S protein (mRNA-RBD)…”
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Artificial COVID-19 T-Cell Immunogen by Borgoyakova, M. B., Karpenko, L. I., Rudometov, A. P., Starostina, E. V., Zadorozhny, A. M., Kisakova, L. A., Kisakov, D. N., Sharabrin, S. V., Ilyichev, A. A., Bazhan, S. I.

“…An artificial T-cell immunogen consisting of conserved fragments of different proteins of the SARS-CoV-2 virus and its immunogenic properties were studied in…”
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DNA Vaccine Encoding the Artificial T-Cell Polyepitope Immunogen of Tick-Borne Encephalitis Virus by Kisakov, D. N., Antonets, D. V., Shaburova, E. V., Kisakova, L. A., Tigeeva, E. V., Yakovlev, V. A., Starostina, E. V., Borgoyakova, M. B., Protopopova, E. V., Svyatchenko, V. A., Loktev, V. B., Rudometov, A. P., Ilyichev, A. A., Nepomnyashchikh, T. S., Karpenko, L. I.

“…A promising approach to the development of new means for preventing infection caused by tick-borne encephalitis virus can be DNA vaccines encoding polyepitope…”
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Immunogenicity of the DNA/Protein Combined Vaccine against COVID-19 by Borgoyakova, M. B., Karpenko, L. I., Merkulyeva, I. A., Shcherbakov, D. N., Rudometov, A. P., Starostina, E. V., Shanshin, D. V., Isaeva, A. A., Nesmeyanova, V. S., Volkova, N. V., Belenkaya, S. V., Volosnikova, E. A., Zadorozhny, A. M., Orlova, L. A., Zaykovskaya, A. V., Pyankov, O. V., Bazhan, S. I., Ilyichev, A. A.

“…During the COVID-19 pandemic, the development of prophylactic vaccines, including those based on new platforms, became highly relevant. One such platform is…”
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Model systems of human immunodef iciency virus (HIV-1) for in vitro eff icacy assessment of candidate vaccines and drugs against HIV-1 by Rudometova, N B, Shcherbakov, D N, Rudometov, A P, Ilyichev, A A, Karpenko, L I

“…HIV infection still remains a major challenge for healthcare systems of the world. There are several aspects on counteracting the HIV/AIDS epidemic. The f irst…”
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mRNA technology as one of the promising platforms for the SARS-CoV-2 vaccine development by Ilyichev, A A, Orlova, L A, Sharabrin, S V, Karpenko, L I

“…After the genome sequence of SARS-CoV-2 (Severe acute respiratory syndrome-related coronavirus 2) was published and the number of infected people began to…”
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Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies by Chikaev, A. N., Rudometov, A. P., Merkulyeva, Yu. A., Karpenko, L. I.

“…Combinatorial biology methods offer a good solution for targeting interactions of specific molecules by a high-throughput screening and are widely used for…”
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5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growth by Alexandrova, L. A., Efremenkova, O. V., Andronova, V. L., Galegov, G. A., Solyev, P. N., Karpenko, I. L., Kochetkov, S. N.

“…A series of 5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine have been synthesized by the interaction of…”
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mRNA Vaccine Platform: mRNA Production and Delivery by Litvinova, V. R., Rudometov, A. P., Karpenko, L. I., Ilyichev, A. A.

“…— Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very…”
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Design of Polyepitope DNA Vaccine against Breast Carcinoma Cells and Analysis of Its Expression in Dendritic Cells by Nazarkina, Zh. K., Khar’kova, M. V., Antonets, D. V., Morozkin, E. S., Bazhan, S. I., Karpenko, L. I., Vlasov, V. V., Ilyichev, A. A., Laktionov, P. P.

“…Polyepitope DNA vaccine inducing T-cell-mediated immune response against cancer-specific antigens is a promising tool for selective elimination of tumor cells…”
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Rational design based synthetic polyepitope DNA vaccine for eliciting HIV-specific CD8+ T cell responses by Bazhan, S.I., Karpenko, L.I., Ilyicheva, T.N., Belavin, P.A., Seregin, S.V., Danilyuk, N.K., Antonets, D.V., Ilyichev, A.A.

“…Advances in defining HIV-1 CD8+ T cell epitopes and understanding endogenous MHC class I antigen processing enable the rational design of polyepitope vaccines…”
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Cytotoxicity Studies of 5-Arylaminouracil Derivatives by Kezin, V. A., Matyugina, E. S., Surzhikov, S. A., Novikov, M. S., Maslova, A. A., Karpenko, I. L., Ivanov, A. V., Kochetkov, S. N., Khandazhinskaya, A. L.

“…We have previously shown that 5-arylaminouracil derivatives can inhibit HIV-1, herpesviruses, mycobacteria, and other pathogens through various mechanisms. The…”
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1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors by Deev, S.L., Yasko, M.V., Karpenko, I.L., Korovina, A.N., Khandazhinskaya, A.L., Andronova, V.L., Galegov, G.A., Shestakova, T.S., Ulomskii, E.N., Rusinov, V.L., Chupakhin, O.N., Kukhanova, M.K.

“…Structure of synthesized compounds. A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from…”
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Construction and Characterization of HIV-1 env-Pseudoviruses of the Recombinant Form CRF63_02A and Subtype A6 by Rudometova, N. B., Shcherbakova, N. S., Shcherbakov, D. N., Taranov, O. S., Zaitsev, B. N., Karpenko, L. I.

“…HIV-1 env -pseudoviruses are a useful tool in the search for antiviral drugs (entry inhibitors) and evaluation of the efficacy of HIV-1 vaccines. Given the…”
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An Attenuated and Highly Immunogenic Variant of the Vaccinia Virus by Shchelkunov, S N, Yakubitskiy, S N, Titova, K A, Pyankov, S A, Shulgina, I S, Starostina, E V, Borgoyakova, M B, Kisakov, D N, Karpenko, L I, Shchelkunova, G A, Sergeev, A A

“…The vaccinia virus (VACV) has been used for prophylactic immunization against smallpox for many decades. However, the VACV-based vaccine had been highly…”
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Effect of the ati Gene Deletion on the Pathogenicity and Immunogenicity of the Vaccinia Virus by Yakubitskiy, S N, Sergeev, A A, Titova, K A, Shulgina, I S, Starostina, E V, Borgoyakova, M B, Karpenko, L I, Shchelkunov, S N

“…Among the nonvirion proteins of the vaccinia virus (VACV), a 94-kDa long protein is most abundantly present; the protein is a truncated form of the 150-kDa…”
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Comparison of the Effectiveness of Transepidemal and Intradermal Immunization of Mice with the Vacinia Virus by Shchelkunov, S N, Sergeev, A A, Titova, K A, Pyankov, S A, Starostina, E V, Borgoyakova, M B, Kisakova, L A, Kisakov, D N, Karpenko, L I, Yakubitskiy, S N

“…The spread of the monkeypox virus infection among humans in many countries outside of Africa, which started in 2022, is now drawing the attention of the…”
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Immunogenic Properties of the DNA Construct Encoding the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein by Borgoyakova, M. B., Karpenko, L. I., Rudometov, A. P., Shanshin, D. V., Isaeva, A. A., Nesmeyanova, V. S., Volkova, N. V., Belenkaya, S. V., Murashkin, D. E., Shcherbakov, D. N., Volosnikova, E. A., Starostina, E. V., Orlova, L. A., Danilchenko, N. V., Zaikovskaya, A. V., Pyankov, O. V., Ilyichev, A. A.

“…— The development of preventive vaccines became the first order task in the COVID-19 pandemic caused by SARS-CoV-2. This paper reports the construction of the…”
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