Search Results - "Karpen, Gary"

Heterochromatin: Guardian of the Genome by Janssen, Aniek, Colmenares, Serafin U, Karpen, Gary H

“…Constitutive heterochromatin is a major component of the eukaryotic nucleus and is essential for the maintenance of genome stability. Highly concentrated at…”
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Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair by Chiolo, Irene, Minoda, Aki, Colmenares, Serafin U., Polyzos, Aris, Costes, Sylvain V., Karpen, Gary H.

“…Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to genome integrity, but information about how such lesions are…”
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Phase separation drives heterochromatin domain formation by Strom, Amy R., Emelyanov, Alexander V., Mir, Mustafa, Fyodorov, Dmitry V., Darzacq, Xavier, Karpen, Gary H.

“…HP1a can nucleate into foci that display liquid properties during the early stages of heterochromatin domain formation in Drosophila embryos, suggesting that…”
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Epigenetic regulation of centromeric chromatin: old dogs, new tricks? by Allshire, Robin C, Karpen, Gary H

“…Key Points Chromosomal DNA is packaged with histones into nucleosomes. Following replication, sister-chromatid segregation is orchestrated to ensure that each…”
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Heterochromatic breaks move to the nuclear periphery to continue recombinational repair by Ryu, Taehyun, Spatola, Brett, Delabaere, Laetitia, Bowlin, Katherine, Hopp, Hannah, Kunitake, Ryan, Karpen, Gary H., Chiolo, Irene

“…Heterochromatin mostly comprises repeated sequences prone to harmful ectopic recombination during double-strand break (DSB) repair. In Drosophila cells, ‘safe’…”
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Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy by Zhang, Weiguo, Mao, Jian-Hua, Zhu, Wei, Jain, Anshu K., Liu, Ke, Brown, James B., Karpen, Gary H.

“…Chromosomal instability (CIN) is a hallmark of cancer that contributes to tumour heterogeneity and other malignant properties. Aberrant centromere and…”
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Heterochromatic genome stability requires regulators of histone H3 K9 methylation by Peng, Jamy C, Karpen, Gary H

“…Heterochromatin contains many repetitive DNA elements and few protein-encoding genes, yet it is essential for chromosome organization and inheritance. Here, we…”
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Pervasive epigenetic effects of Drosophila euchromatic transposable elements impact their evolution by Lee, Yuh Chwen G, Karpen, Gary H

“…Transposable elements (TEs) are widespread genomic parasites, and their evolution has remained a critical question in evolutionary genomics. Here, we study the…”
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Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A by Janssen, Aniek, Colmenares, Serafin U, Lee, Timothy, Karpen, Gary H

“…Repair of DNA double-strand breaks (DSBs) must be orchestrated properly within diverse chromatin domains in order to maintain genetic stability. Euchromatin…”
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H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability by Peng, Jamy C, Karpen, Gary H

“…Investigations aimed at identifying regulators of nuclear architecture in Drosophila demonstrated that cells lacking H3K9 methylation and RNA interference…”
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Assembly of Drosophila centromeric chromatin proteins during mitosis by Mellone, Barbara G, Grive, Kathryn J, Shteyn, Vladimir, Bowers, Sarion R, Oderberg, Isaac, Karpen, Gary H

“…Semi-conservative segregation of nucleosomes to sister chromatids during DNA replication creates gaps that must be filled by new nucleosome assembly. We…”
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The Release 6 reference sequence of the Drosophila melanogaster genome by Hoskins, Roger A, Carlson, Joseph W, Wan, Kenneth H, Park, Soo, Mendez, Ivonne, Galle, Samuel E, Booth, Benjamin W, Pfeiffer, Barret D, George, Reed A, Svirskas, Robert, Krzywinski, Martin, Schein, Jacqueline, Accardo, Maria Carmela, Damia, Elisabetta, Messina, Giovanni, Méndez-Lago, María, de Pablos, Beatriz, Demakova, Olga V, Andreyeva, Evgeniya N, Boldyreva, Lidiya V, Marra, Marco, Carvalho, A Bernardo, Dimitri, Patrizio, Villasante, Alfredo, Zhimulev, Igor F, Rubin, Gerald M, Karpen, Gary H, Celniker, Susan E

“…Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies of heredity, development, metabolism, behavior, and human disease…”
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DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5 by Kendek, Apfrida, Sandron, Arianna, Lambooij, Jan-Paul, Colmenares, Serafin U, Pociunaite, Severina M, Gooijers, Iris, de Groot, Lars, Karpen, Gary H, Janssen, Aniek

“…Cells employ diverse strategies to repair double-strand breaks (DSBs), a dangerous form of DNA damage that threatens genome integrity. Eukaryotic nuclei…”
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Assembly of Drosophila Centromeric Nucleosomes Requires CID Dimerization by Zhang, Weiguo, Colmenares, Serafin U., Karpen, Gary H.

“…Centromeres are essential chromosomal regions required for kinetochore assembly and chromosome segregation. The composition and organization of centromeric…”
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Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin by Lee, Yuh Chwen G, Ogiyama, Yuki, Martins, Nuno M C, Beliveau, Brian J, Acevedo, David, Wu, C-Ting, Cavalli, Giacomo, Karpen, Gary H

“…Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of…”
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An assessment of histone-modification antibody quality by Park, Peter J, Karpen, Gary H, Hawkins, R David, Lieb, Jason D, Egelhofer, Thea A, Minoda, Aki, Klugman, Sarit, Lee, Kyungjoon, Kolasinska-Zwierz, Paulina, Alekseyenko, Artyom A, Cheung, Ming-Sin, Day, Daniel S, Gadel, Sarah, Gorchakov, Andrey A, Gu, Tingting, Kharchenko, Peter V, Kuan, Samantha, Latorre, Isabel, Linder-Basso, Daniela, Luu, Ying, Ngo, Queminh, Perry, Marc, Rechtsteiner, Andreas, Riddle, Nicole C, Schwartz, Yuri B, Shanower, Gregory A, Vielle, Anne, Ahringer, Julie, Elgin, Sarah C R, Kuroda, Mitzi I, Pirrotta, Vincenzo, Ren, Bing, Strome, Susan

“…Antibodies are a primary tool to assess histone post-translational modifications. However, different antibodies and batches might vary in their ability to…”
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Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis by Zhang, Weiguo, Karpen, Gary H., Zhang, Qing

“…Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7…”
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Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA by Langley, Sasha A, Miga, Karen H, Karpen, Gary H, Langley, Charles H

“…Despite critical roles in chromosome segregation and disease, the repetitive structure and vast size of centromeres and their surrounding heterochromatic…”
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Comprehensive analysis of the chromatin landscape in Drosophila melanogaster by Karpen, Gary H, Park, Peter J, Kharchenko, Peter V, Alekseyenko, Artyom A, Schwartz, Yuri B, Minoda, Aki, Riddle, Nicole C, Ernst, Jason, Sabo, Peter J, Larschan, Erica, Gorchakov, Andrey A, Gu, Tingting, Linder-Basso, Daniela, Plachetka, Annette, Shanower, Gregory, Tolstorukov, Michael Y, Luquette, Lovelace J, Xi, Ruibin, Jung, Youngsook L, Park, Richard W, Bishop, Eric P, Canfield, Theresa P, Sandstrom, Richard, Thurman, Robert E, MacAlpine, David M, Stamatoyannopoulos, John A, Kellis, Manolis, Elgin, Sarah C. R, Kuroda, Mitzi I, Pirrotta, Vincenzo

“…Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and…”
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Epigenetic regulation of heterochromatic DNA stability by Peng, Jamy C, Karpen, Gary H

“…In this review we summarize recent studies that demonstrate the importance of epigenetic mechanisms for maintaining genome integrity, specifically with respect…”
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