Search Results - "Karp, Natasha A"

Statistical simulations show that scientists need not increase overall sample size by default when including both sexes in in vivo studies by Phillips, Benjamin, Haschler, Timo N, Karp, Natasha A

“…In recent years, there has been a strong drive to improve the inclusion of animals of both sexes in the design of in vivo research studies, driven by a need to…”
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T, Baker, Monya, Browne, William J, Clark, Alejandra, Cuthill, Innes C, Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T, Howells, David W, Karp, Natasha A, Lazic, Stanley E, Lidster, Katie, MacCallum, Catriona J, Macleod, Malcolm, Pearl, Esther J, Petersen, Ole H, Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S, Silberberg, Shai D, Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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Reproducible preclinical research-Is embracing variability the answer? by Karp, Natasha A

“…Translational failures and replication issues of published research are undermining preclinical research and, if the outcomes are questionable, raise ethical…”
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Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 by Percie du Sert, Nathalie, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T, Baker, Monya, Browne, William J, Clark, Alejandra, Cuthill, Innes C, Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T, Howells, David W, Hurst, Viki, Karp, Natasha A, Lazic, Stanley E, Lidster, Katie, MacCallum, Catriona J, Macleod, Malcolm, Pearl, Esther J, Petersen, Ole H, Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S, Silberberg, Shai D, Steckler, Thomas, Würbel, Hanno

“…Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting is vital to this process; it allows readers to…”
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T., Howells, David W., Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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The ARRIVE guidelines 2.0: updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T., Howells, David W., Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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A qualitative study of the barriers to using blinding in in vivo experiments and suggestions for improvement by Karp, Natasha A, Pearl, Esther J, Stringer, Emma J, Barkus, Chris, Ulrichsen, Jane Coates, Percie du Sert, Nathalie

“…In animal experiments, blinding (also known as masking) is a methodological strategy to reduce the risk that scientists, animal care staff, or other staff…”
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T., Howells, David W., Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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A response to "Realism and robustness require increased sample size when studying both sexes" by Phillips, Benjamin, Haschler, Timo N, Karp, Natasha A

“…[...]Drobniak and colleagues [2] argue that the variance between the sexes will inevitably differ due to Taylor’s law, where the mean and the standard…”
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Genome-wide in vivo screen identifies novel host regulators of metastatic colonization by van der Weyden, Louise, Arends, Mark J., Campbell, Andrew D., Bald, Tobias, Wardle-Jones, Hannah, Griggs, Nicola, Velasco-Herrera, Martin Del Castillo, Tüting, Thomas, Sansom, Owen J., Karp, Natasha A., Clare, Simon, Gleeson, Diane, Ryder, Edward, Galli, Antonella, Tuck, Elizabeth, Cambridge, Emma L., Voet, Thierry, Macaulay, Iain C., Wong, Kim, Spiegel, Sarah, Speak, Anneliese O., Adams, David J.

“…Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an…”
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Addressing Accuracy and Precision Issues in iTRAQ Quantitation by Karp, Natasha A., Huber, Wolfgang, Sadowski, Pawel G., Charles, Philip D., Hester, Svenja V., Lilley, Kathryn S.

“…iTRAQ (isobaric tags for relative or absolute quantitation) is a mass spectrometry technology that allows quantitative comparison of protein abundance by…”
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T, Baker, Monya, Browne, William J, Clark, Alejandra, Cuthill, Innes C, Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T, Howells, David W, Karp, Natasha A, Lazic, Stanley E, Lidster, Katie, MacCallum, Catriona J, Macleod, Malcolm, Pearl, Esther J, Petersen, Ole H, Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S, Silberberg, Shai D, Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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Reproducibility and replicability of rodent phenotyping in preclinical studies by Kafkafi, Neri, Agassi, Joseph, Chesler, Elissa J., Crabbe, John C., Crusio, Wim E., Eilam, David, Gerlai, Robert, Golani, Ilan, Gomez-Marin, Alex, Heller, Ruth, Iraqi, Fuad, Jaljuli, Iman, Karp, Natasha A., Morgan, Hugh, Nicholson, George, Pfaff, Donald W., Richter, S. Helene, Stark, Philip B., Stiedl, Oliver, Stodden, Victoria, Tarantino, Lisa M., Tucci, Valter, Valdar, William, Williams, Robert W., Würbel, Hanno, Benjamini, Yoav

“…•Many published scientific discoveries fail to replicate.•The field of mouse behavioral phenotyping was one of the first to raise this concern.•Replicability…”
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Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project by Redfern, William S, Tse, Karen, Grant, Claire, Keerie, Amy, Simpson, David J, Pedersen, John C, Rimmer, Victoria, Leslie, Lauren, Klein, Stephanie K, Karp, Natasha A, Sillito, Rowland, Chartsias, Agis, Lukins, Tim, Heward, James, Vickers, Catherine, Chapman, Kathryn, Armstrong, J Douglas

“…Measuring the activity and temperature of rats is commonly required in biomedical research. Conventional approaches necessitate single housing, which affects…”
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The Experimental Design Assistant by Percie du Sert, Nathalie, Bamsey, Ian, Bate, Simon T, Berdoy, Manuel, Clark, Robin A, Cuthill, Innes, Fry, Derek, Karp, Natasha A, Macleod, Malcolm, Moon, Lawrence, Stanford, S Clare, Lings, Brian

“…Addressing the common problems that researchers encounter when designing and analysing animal experiments will improve the reliability of in vivo research. In…”
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PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data by Kurbatova, Natalja, Mason, Jeremy C, Morgan, Hugh, Meehan, Terrence F, Karp, Natasha A

“…The lack of reproducibility with animal phenotyping experiments is a growing concern among the biomedical community. One contributing factor is the inadequate…”
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The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data by Koscielny, Gautier, Yaikhom, Gagarine, Iyer, Vivek, Meehan, Terrence F, Morgan, Hugh, Atienza-Herrero, Julian, Blake, Andrew, Chen, Chao-Kung, Easty, Richard, Di Fenza, Armida, Fiegel, Tanja, Grifiths, Mark, Horne, Alan, Karp, Natasha A, Kurbatova, Natalja, Mason, Jeremy C, Matthews, Peter, Oakley, Darren J, Qazi, Asfand, Regnart, Jack, Retha, Ahmad, Santos, Luis A, Sneddon, Duncan J, Warren, Jonathan, Westerberg, Henrik, Wilson, Robert J, Melvin, David G, Smedley, Damian, Brown, Steve D M, Flicek, Paul, Skarnes, William C, Mallon, Ann-Marie, Parkinson, Helen

“…The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of…”
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Investigating sample pooling strategies for DIGE experiments to address biological variability by Karp, Natasha A, Lilley, Kathryn S

“…If biological questions are to be answered using quantitative proteomics, it is essential to design experiments which have sufficient power to be able to…”
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Do multiple experimenters improve the reproducibility of animal studies? by von Kortzfleisch, Vanessa Tabea, Ambrée, Oliver, Karp, Natasha A, Meyer, Neele, Novak, Janja, Palme, Rupert, Rosso, Marianna, Touma, Chadi, Würbel, Hanno, Kaiser, Sylvia, Sachser, Norbert, Richter, S Helene

“…The credibility of scientific research has been seriously questioned by the widely claimed "reproducibility crisis". In light of this crisis, there is a…”
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A common control group - optimising the experiment design to maximise sensitivity by Bate, Simon, Karp, Natasha A

“…Methods for choosing an appropriate sample size in animal experiments have received much attention in the statistical and biological literature. Due to ethical…”
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