Search Results - "Karp, J."

Impact of detector design on imaging performance of a long axial field-of-view, whole-body PET scanner by Surti, S, Karp, J S

“…Current generation of commercial time-of-flight (TOF) PET scanners utilize 20-25 mm thick LSO or LYSO crystals and have an axial FOV (AFOV) in the range of…”
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Impact of event positioning algorithm on performance of a whole-body PET scanner using one-to-one coupled detectors by Surti, S, Karp, J S

“…The advent of silicon photomultipliers (SiPMs) has introduced the possibility of increased detector performance in commercial whole-body PET scanners. The…”
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Recent developments in time-of-flight PET by Vandenberghe, S., Mikhaylova, E., D’Hoe, E., Mollet, P., Karp, J. S.

“…While the first time-of-flight (TOF)-positron emission tomography (PET) systems were already built in the early 1980s, limited clinical studies were acquired…”
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P‐IG‐38 | Rh Immune Globulin Serologically Detected Within Minutes or Hours After Intramuscular Administration by Christensen, A., Karp, J., Everetts, J., Ly, V., Guarente, J.

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Design considerations for a limited angle, dedicated breast, TOF PET scanner by Surti, S, Karp, J S

“…Development of partial ring, dedicated breast positron emission tomography (PET) scanners is an active area of research. Due to the limited angular coverage,…”
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Experimental evaluation of a simple lesion detection task with time-of-flight PET by Surti, S, Karp, J S

“…A new generation of high-performance, time-of-flight (TOF) PET scanners have recently been developed. In earlier works, the gain with TOF information was…”
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Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives by Masuzaki, Ryota, Kanda, Tatsuo, Sasaki, Reina, Matsumoto, Naoki, Ogawa, Masahiro, Matsuoka, Shunichi, Karp, Seth J, Moriyama, Mitsuhiko

“…Liver fibrosis is one of the risk factors for hepatocellular carcinoma (HCC) development. The staging of liver fibrosis can be evaluated only via a liver…”
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Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters by Karim, H T, Andreescu, C, Tudorascu, D, Smagula, S F, Butters, M A, Karp, J F, Reynolds, C, Aizenstein, H J

“…Previous studies in late-life depression (LLD) have found that patients have altered intrinsic functional connectivity in the dorsal default mode network (DMN)…”
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Study of PET scanner designs using clinical metrics to optimize the scanner axial FOV and crystal thickness by Surti, S, Werner, M E, Karp, J S

“…The aim of this study is to understand the trade-off between crystal thickness and scanner axial field-of-view FOV (AFOV) for clinical PET imaging. Clinical…”
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Suppressors of Cytokine Signaling and Hepatocellular Carcinoma by Masuzaki, Ryota, Kanda, Tatsuo, Sasaki, Reina, Matsumoto, Naoki, Nirei, Kazushige, Ogawa, Masahiro, Karp, Seth J, Moriyama, Mitsuhiko, Kogure, Hirofumi

“…Cytokines are secreted soluble glycoproteins that regulate cellular growth, proliferation, and differentiation. Suppressors of cytokine signaling (SOCS)…”
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MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors by Knorr, K L B, Schneider, P A, Meng, X W, Dai, H, Smith, B D, Hess, A D, Karp, J E, Kaufmann, S H

“…MLN4924 (pevonedistat), an inhibitor of the Nedd8 activating enzyme (NAE), has exhibited promising clinical activity in acute myelogenous leukemia (AML). Here…”
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Variability in Organ Procurement Organization Performance by Individual Hospital in the United States by Johnson, Wali, Kraft, Kathryn, Chotai, Pranit, Lynch, Raymond, Dittus, Robert S, Goldberg, David, Ye, Fei, Doby, Brianna, Schaubel, Douglas E, Shah, Malay B, Karp, Seth J

“…Availability of organs inadequately addresses the need of patients waiting for a transplant. To estimate the true number of donor patients in the United States…”
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TOF PET offset calibration from clinical data by Werner, M E, Karp, J S

“…In this paper, we present a timing calibration technique for time-of-flight positron emission tomography (TOF PET) that eliminates the need for a specialized…”
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Public attitudes toward contemporary issues in liver allocation by O'Dell, Heather W., McMichael, Benjamin J., Lee, Suzie, Karp, Jay L., VanHorn, R. Lawrence, Karp, Seth J.

“…Allocation of scarce livers for transplantation seeks to balance competing ethical principles of autonomy, utility, and justice. Given the history and ongoing…”
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Advances in understanding the mechanisms and management of persistent pain in older adults by Karp, J. F., Shega, J. W., Morone, N. E., Weiner, D. K.

“…Older adults with persistent pain are not simply a chronologically older version of younger pain patients. Pain-related disability in older adults may be…”
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Naltrexone modulates contextual processing in depression by Chen, J, Mizuno, A, Lyew, T, Karim, H T, Karp, J F, Dombrovski, A Y, Peciña, M

“…Context, the information surrounding an experience, can significantly alter the meaning and the affective responses to events. Yet the biological mechanisms…”
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JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained by STEENSMA, D. P, MCCLURE, R. F, KARP, J. E, TEFFERI, A, LASHO, T. L, POWELL, H. L, DEWALD, G. W, KAUFMANN, S. H

“…Signal transducer and activator of transcription (STAT) proteins are phosphorylated and activated by Janus kinases (JAKs). Recently, several groups identified…”
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Association between change in brain gray matter volume, cognition, and depression severity: Pre- and post- antidepressant pharmacotherapy for late-life depression by Droppa, K., Karim, H.T., Tudorascu, D.L., Karp, J.F., Reynolds, C.F., Aizenstein, H.J., Butters, M.A.

“…Late-life depression (LLD) is associated with cognitive impairments and reduced gray matter volume (GMV); however the mechanisms underlying this association…”
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Depressive symptoms and cerebral microvascular disease in adults with Type 1 diabetes mellitus by Nunley, K. A., Karp, J. F., Orchard, T. J., Costacou, T., Aizenstein, H. J., Jennings, J. R., Rosano, C.

“…Aim To assess the prevalence of, and risk factors for, depressive symptoms, comparing a sample of middle‐aged adults with and without juvenile‐onset Type 1…”
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A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias by Pratz, K W, Cho, E, Levis, M J, Karp, J E, Gore, S D, McDevitt, M, Stine, A, Zhao, M, Baker, S D, Carducci, M A, Wright, J J, Rudek, M A, Smith, B D

“…We report the results of a phase I dose escalation trial of the multikinase inhibitor sorafenib in relapsed and refractory acute leukemia patients using an…”
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