Search Results - "Karnoub, Antoine E."

MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis by Cuiffo, Benjamin G., Campagne, Antoine, Bell, George W., Lembo, Antonio, Orso, Francesca, Lien, Evan C., Bhasin, Manoj K., Raimo, Monica, Hanson, Summer E., Marusyk, Andriy, El-Ashry, Dorraya, Hematti, Peiman, Polyak, Kornelia, Mechta-Grigoriou, Fatima, Mariani, Odette, Volinia, Stefano, Vincent-Salomon, Anne, Taverna, Daniela, Karnoub, Antoine E.

“…Mesenchymal stem/stromal cells (MSCs) are progenitor cells shown to participate in breast tumor stroma formation and to promote metastasis. Despite expanding…”
Get full text

Mesenchymal stem cells in tumor development: Emerging roles and concepts by Cuiffo, Benjamin G., Karnoub, Antoine E.

“…Mesenchymal stem cells (MSCs) are multipotent progenitor cells that participate in the structural and functional maintenance of connective tissues under normal…”
Get full text

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy by El-Haibi, Christelle P., Bell, George W., Zhang, Jiangwen, Collmann, Anthony Y., Wood, David, Scherber, Cally M., Csizmadia, Eva, Mariani, Odette, Zhu, Cuihua, Campagne, Antoine, Toner, Mehmet, Bhatia, Sangeeta N., Irimia, Daniel, Vincent-Salomon, Anne, Karnoub, Antoine E.

“…Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the ability to differentiate into multiple mesoderm lineages in the course of normal tissue…”
Get full text

Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone by Reynaud, Caroline, Ferreras, Laura, Di Mauro, Paola, Kan, Casina, Croset, Martine, Bonnelye, Edith, Pez, Floriane, Thomas, Clémence, Aimond, Géraldine, Karnoub, Antoine E, Brevet, Marie, Clézardin, Philippe

“…Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase whose primary function is to drive collagen crosslinking and extracellular matrix stiffness…”
Get full text

Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes by Ince, Tan A., Richardson, Andrea L., Bell, George W., Saitoh, Maki, Godar, Samuel, Karnoub, Antoine E., Iglehart, James D., Weinberg, Robert A.

“…We investigated the influence of normal cell phenotype on the neoplastic phenotype by comparing tumors derived from two different normal human mammary…”
Get full text

In vivo gain-of-function cDNA library screening for colonization genes in a mouse model of pulmonary metastasis by Tu, Zhenbo, Karnoub, Antoine E.

“…We provide a protocol for gain-of-function (GOF) cDNA screen of genes that foster cancer cell colonization of secondary tissues, the last and most lethal step…”
Get full text

Busulfan Chemotherapy Downregulates TAF7/TNF-α Signaling in Male Germ Cell Dysfunction by Huang, Daoyuan, Tu, Zhenbo, Karnoub, Antoine E, Wei, Wenyi, Rezaeian, Abdol-Hossein

“…: Busulfan is an FDA-approved alkylating drug used in the chemotherapy of advanced acute myeloid leukemia. The precise mechanisms by which Busulfan kills…”
Get full text

Mesenchymal stem/stromal cells in breast cancer development and management by Tu, Zhenbo, Karnoub, Antoine E.

“…Mesenchymal stem/stromal cells (MSCs) encompass a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body…”
Get full text

Mesenchymal Stem Cells in the Pathogenesis and Therapy of Breast Cancer by El-Haibi, Christelle P, Karnoub, Antoine E

“…Mesenchymal stem cells (MSCs) are a heterogeneous mix of stromal stem cells that can give rise to cells of mesodermal lineages, namely adipocytes, osteocytes…”
Get full text

Lysyl oxidase at the crossroads of mesenchymal stem cells and epithelial-mesenchymal transition by Thomas, Clémence, Karnoub, Antoine E

Get full text

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation by SINGH, Anurag, KARNOUB, Antoine E, PALMBY, Todd R, LENGYEL, Ernst, SONDEK, John, DER, Channing J

“…A novel splice variant of Rac1, designated Rac1b, is expressed in human breast and colon carcinoma cells. Rac1b contains an additional 19 amino-acid insert…”
Get full text

In vivo library screening identifies the metabolic enzyme aldolase A as a promoter of metastatic lung colonization by Tu, Zhenbo, Hou, Shengqi, Zheng, Yurong, Abuduli, Maerjianghan, Onder, Tamer, Intlekofer, Andrew M., Karnoub, Antoine E.

“…Elucidations of the factors that promote the growth of disseminated tumor cells (DTCs) into life-threatening lesions stand to provide much needed prognostic…”
Get full text

Ras oncogenes: split personalities by Karnoub, Antoine E, Weinberg, Robert A

“…Key Points Oncogenic mutations of Ras, which are found in human tumours, tumour cell lines and in carcinogen-induced experimental tumours, cause the…”
Get full text

The LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer by Tu, Zhenbo, Schmoellerl, Johannes, Mariani, Odette, Zheng, Yurong, Hu, Yi, Vincent-Salomon, Anne, Karnoub, Antoine E.

“…The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal…”
Get full text

Distinct requirements for Ras oncogenesis in human versus mouse cells by Hamad, Nesrin M, Elconin, Joel H, Karnoub, Antoine E, Bai, Wenli, Rich, Jeremy N, Abraham, Robert T, Der, Channing J, Counter, Christopher M

“…The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens or engineered to sporadically…”
Get full text

Endocrine regulation of cancer stem cell compartments in breast tumors by Zheng, Yurong, Karnoub, Antoine E.

“…Cancer cells within breast tumors exist within a hierarchy in which only a small and rare subset of cells is able to regenerate growths with the heterogeneity…”
Get full text

Microenvironmental Regulation of Long Noncoding RNA LINC01133 Promotes Cancer Stem Cell‐Like Phenotypic Traits in Triple‐Negative Breast Cancers by Tu, Zhenbo, Schmöllerl, Johannes, Cuiffo, Benjamin G., Karnoub, Antoine E.

“…The fibrotic tumor microenvironment is a critical player in the pathogenesis of triple‐negative breast cancers (TNBCs), with the presence of fibroblastic…”
Get full text

Long noncoding RNA-mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in triple-negative breast cancer by Tu, Zhenbo, Hu, Yi, Raizada, Devesh, Bassal, Mahmoud A, Tenen, Daniel G, Karnoub, Antoine E

“…The phosphoinositide 3-kinase (PI3K) pathway represents the most hyperactivated oncogenic pathway in triple-negative breast cancer (TNBC), a highly aggressive…”
Get full text

Molecular basis for Rho GTPase signaling specificity by Karnoub, Antoine E, Symons, Marc, Campbell, Sharon L, Der, Channing J

“…There is now considerable evidence for the involvement of aberrant Rho GTPase activation in breast cancer development. Like Ras, Rho GTPases function as…”
Get full text

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis by KARNOUB, Antoine E, DASH, Ajeeta B, VO, Annie P, SULLIVAN, Andrew, BROOKS, Mary W, BELL, George W, RICHARDSON, Andrea L, POLYAK, Kornelia, TUBO, Ross, WEINBERG, Robert A

“…Mesenchymal stem cells have been recently described to localize to breast carcinomas, where they integrate into the tumour-associated stroma. However, the…”
Get full text