Search Results - "Karnik, Sushant"

274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency by Kalaitzidis, Demetrios, Ghonime, Mohammed, Chain, Robert, Jaishankar, Nivedita, Settipane, Davis, Padalia, Zinkal, Zakas, Lauren, Kuppuraju, Meghna, Tetteh, Paul, Dequeant, Mary-Lee, Karnik, Sushant, Massilamany, Chandirasegaran, McEwan, Brigid, Dar, Henia, Allen, Melanie, Serwer, Laura, Nguyen, Thao, Butler-Gauthier, Melanie, Sripakdeevong, Parin, Nagar, Shashwat, Tang, Yin, Flanagan, Nicole, Huang, Elaine, Phuyal, Shashwant, Dunn, Andrew, Koch, Elizabeth, Sula, Erisa, Waldman, Jacob, Zhang, Maria Lei, Loaiza, Cristian, Thorstensen, Erin, Steiger, Keith, Schum, Katie, Urbaez, Kayla, Ma, Anna, Weaver, Annie Yang, Finch, Christopher, Cohen, Sarah, Morrow, PK, Benton, Mark, Terrett, Jonathan

“…BackgroundCTX110, a CD19-directed first-generation CRISPR-edited CAR T cell therapeutic candidate for B-cell lymphoma, has induced clinical responses and…”
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Abstract 3184: Targeting multiple solid tumor types with anti-CD70 allogeneic CAR-T cells by Dequeant, Mary Lee, Karnik, Sushant, Padalia, Zinkal, Tham, Minh Thu, Ho, Tony, Carson, Julie, Terrett, Jonathan A.

“…Abstract CD70 (CD27 ligand) is highly expressed in multiple hematologic malignancies, such as non-Hodgkin lymphoma, multiple myeloma, and chronic lymphocytic…”
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Abstract 879: Functional and single-cell assessment of CRISPR-modified CAR-T cells from NSCLC patients and healthy donors by Padalia, Zinkal, Dunn, Andrew, Karagiannis, Konstantinos, McEwan, Brigid, Kuppuraju, Meghna, Sagert, Jason, Karnik, Sushant, Dequeant, Mary-Lee, Terrett, Jonathan, Kalaitzidis, Demetrios

“…Abstract Cancer patients that have undergone multiple lines of treatment can have dysfunctional immune systems. In both solid tumors and hematological…”
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Abstract 6595: Targeting T cell lymphomas with CRISPR/Cas9-generated anti-CD70 allogeneic CAR-T cells by Karnik, Sushant, Pham, Minh Thu, Keerthipati, Pooja, Padalia, Zinkal, Carson, Julie, Ho, Tony, Morawa, Ewelina, Will, Matthias, Terrett, Jonathan, Dequeant, Mary-Lee

“…Abstract T cell lymphomas account for 10% to 15% of non-Hodgkin lymphomas and are diverse biologically and clinically. Unlike B-cell lymphomas, T cell…”
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Abstract 1537: CD70 knockout: A novel approach to augment CAR-T cell function by Dequeant, Mary-Lee, Sagert, Jason, Kalaitzidis, Demetri, Yu, Hui, Porras, Ashley, McEwan, Brigid, Padalia, Zinkal, Tetteh, Paul, Nguyen, Thao, Dunn, Andrew, Spencer, Sarah, Lee, Nicolette, Dar, Henia, Henderson, Daniel, Karnik, Sushant, Keerthipati, Pooja, Terrett, Jonathan A.

“…Abstract CD70 and its ligand, CD27, have been described as both activating and suppressing for different cell types including B and T cells. There has been…”
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MGMT in Emergence of Melanoma Resistance to Temozolomide by Karnik, Sushant

“…Melanoma incidence has been on the rise and alike many other malignancies, major impediments in its treatment and management are the high metastatic potential…”
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Abstract 5512: CBLB, CISH and CD70 multiplexed gene knockout with CRISPR/Cas9 enhances cytotoxicity of CD70-CAR NK cells and provides greater resistance to TGF-β for cancer immunotherapy by Guo, Chao, Fan, Yanying, Aronov, Alexander, Zhang, Qi, Sahu, Sombeet, Dequéant, Mary-Lee, Guo, Changan, Karnik, Sushant, Leary, Glenn D., Massilamany, Chandirasegaran, Chan, Ivan H., Trager, James B.

“…Abstract Natural killer (NK) cells provide an attractive platform for development of effective cancer immunotherapies. NK cells are known for their ability to…”
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Abstract ND02: CTX112 and CTX131: Next-generation CRISPR/Cas9-engineered allogeneic (allo) CAR T cells incorporating novel edits that increase potency and efficacy in the treatment of lymphoid and solid tumors by Terrett, Jonathan A., Kalaitzidis, Demetrios, Dequeant, Mary-Lee, Karnik, Sushant, Ghonime, Mohammed, Guo, Changan, Chain, Robert, Heath, Heidi, Jaishankar, Nivedita, Yuen, Rachel, Settipane, Davis, Padalia, Zinkal, Zakas, Lauren, Kuppuraju, Meghna, Tetteh, Paul, Massilamany, Chandirasegaran, McEwan, Brigid, Leary, Glenn, Dar, Henia, Ferulo, Daniel, Allen, Melanie, Tipton, Kimberley, Serwer, Laura, Nguyen, Thao, Butler-Gauthier, Melanie, Sripakdeevong, Parin, Nagar, Shashwat D., Tang, Yin, Chaudhari, Hemangi, Flanagan, Nicole, Huang, Elaine, Phuyal, Shashwant, Koch, Elizabeth, Dunn, Andrew, Sula, Erisa, Waldman, Jacob, Loaiza, Cristian, Zhang, Maria Lei, Thorstensen, Erin, Steiger, Keith, Schum, Katie, Urbaez, Kayla, Benton, Mark, Ma, Anna, Cohen, Sarah, Weaver, Annie, Finch, Christopher, Morrow, Phuong Khanh

“…Abstract Allo CAR T cells represent an “off-the-shelf” treatment option that addresses the unmet need for immediately available, potentially curative…”
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Expression of domain III of the envelope protein from GP-78: a Japanese encephalitis virus by Kulkarni, Sahil, Mukherjee, Sandeepan, Das, Krishna Mohan Padmanabha, Prabhudesai, Kaushiki, Deshpande, Nupur, Karnik, Sushant, Chowdhary, Abhay S., Padmanabhan, Usha

“…Acute encephalitis caused by the Japanese encephalitis virus (JEV) represents a growing epidemic and is a cause for concern in Southeast Asia. JEV is…”
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