Search Results - "Karnewar, Santosh"

Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis by Vasamsetti, Sathish Babu, Karnewar, Santosh, Kanugula, Anantha Koteswararao, Thatipalli, Avinash Raj, Kumar, Jerald Mahesh, Kotamraju, Srigiridhar

“…Monocyte-to-macrophage differentiation is a critical event that accentuates atherosclerosis by promoting an inflammatory environment within the vessel wall. In…”
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Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis by Alencar, Gabriel F., Owsiany, Katherine M., Karnewar, Santosh, Sukhavasi, Katyayani, Mocci, Giuseppe, Nguyen, Anh T., Williams, Corey M., Shamsuzzaman, Sohel, Mokry, Michal, Henderson, Christopher A., Haskins, Ryan, Baylis, Richard A., Finn, Aloke V., McNamara, Coleen A., Zunder, Eli R., Venkata, Vamsidhar, Pasterkamp, Gerard, Björkegren, Johan, Bekiranov, Stefan, Owens, Gary K.

“…Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we…”
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High Affinity Neutral Bodipy Fluorophores for Mitochondrial Tracking by Gayathri, Thumuganti, Karnewar, Santosh, Kotamraju, Srigiridhar, Singh, Surya Prakash

“…We report the first high affinity neutral Bodipy fluorophores for selective imaging of mitochondria with notable sensitivity (∼100 nM) and insignificant…”
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Mitochondrial-targeted curcuminoids: a strategy to enhance bioavailability and anticancer efficacy of curcumin by Reddy, Cheruku Apoorva, Somepalli, Venkateswarlu, Golakoti, Trimurtulu, Kanugula, Anantha KoteswaraRao, Karnewar, Santosh, Rajendiran, Karthikraj, Vasagiri, Nagarjuna, Prabhakar, Sripadi, Kuppusamy, Periannan, Kotamraju, Srigiridhar, Kutala, Vijay Kumar

“…Although the anti-cancer effects of curcumin has been shown in various cancer cell types, in vitro, pre-clinical and clinical studies showed only a limited…”
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KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation by Bulut, Gamze B., Alencar, Gabriel F., Owsiany, Katherine M., Nguyen, Anh T., Karnewar, Santosh, Haskins, Ryan M., Waller, Lillian K., Cherepanova, Olga A., Deaton, Rebecca A., Shankman, Laura S., Keller, Susanna R., Owens, Gary K.

“…OBJECTIVE:Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that…”
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Synthesis and Biological Evaluation of Imidazopyridine-Oxindole Conjugates as Microtubule-Targeting Agents by Kamal, Ahmed, Reddy, Vangala Santhosh, Karnewar, Santosh, Chourasiya, Sumit S., Shaik, Anver Basha, Kumar, G. Bharath, Kishor, Chandan, Reddy, M. Kashi, Narasimha Rao, M. P., Nagabhushana, Ananthamurthy, Ramakrishna, Kallaganti V. S., Addlagatta, Anthony, Kotamraju, Srigiridhar

“…A library of imidazopyridine–oxindole conjugates was synthesised and investigated for anticancer activity against various human cancer cell lines. Some of the…”
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Synthesis, antimicrobial and cytotoxic activities of novel 4-trifluoromethyl-(1,2,3)-thiadiazolo-5-carboxylic acid hydrazide Schiff’s bases by Sambasiva Rao, P., Kurumurthy, C., Veeraswamy, B., Santhosh kumar, G., Narsaiah, B., Pranay Kumar, K., Murthy, U. S. N., Karnewar, Santosh, Kotamraju, Srigiridhar

“…A series of novel 1,2,3-thiadiazolo-5-carboxylic acid hydrazide Schiff’s bases 4a – 4r were prepared starting from ethyl-4,4,4-trifluoroacetoacetate and ethyl…”
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Abstract P3124: Treatment Of Apoe-/- Mice With Advanced Atherosclerosis With The Senolytic Agent Abt-263 Caused Increased Mortality And Was Associated With Increased Endo-mt But Reduced Acta2 Cap Thickness And Collagen Content by Karnewar, Santosh, Karnewar, Vaishnavi, Owens, Gary K

“…BackgroundPlaque rupture and erosion of advanced atherosclerotic lesions resulting in ischemic heart disease or stroke are the leading worldwide cause of…”
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Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction by Karnewar, Santosh, Neeli, Praveen Kumar, Panuganti, Devayani, Kotagiri, Sasikumar, Mallappa, Sreevidya, Jain, Nishant, Jerald, Mahesh Kumar, Kotamraju, Srigiridhar

“…Endothelial senescence in conjunction with mitochondrial dysfunction orchestrates age-associated cardiovascular disorders. In this study we investigated the…”
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Mitochondria-targeted esculetin mitigates atherosclerosis in the setting of aging via the modulation of SIRT1-mediated vascular cell senescence and mitochondrial function in Apoe−/− mice by Karnewar, Santosh, Pulipaka, Sriravali, Katta, Sujana, Panuganti, Devayani, Neeli, Praveen Kumar, Thennati, Rajamannar, Jerald, Mahesh Kumar, Kotamraju, Srigiridhar

“…Age is a dominant and independent risk factor for the development of atherosclerosis, a major cardiovascular disease, and if left untreated leads to myocardial…”
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DOT1L regulates MTDH‐mediated angiogenesis in triple‐negative breast cancer: intermediacy of NF‐κB‐HIF1α axis by Neeli, Praveen Kumar, Sahoo, Shashikanta, Karnewar, Santosh, Singuru, Gajalakshmi, Pulipaka, Sriravali, Annamaneni, Sandhya, Kotamraju, Srigiridhar

“…DOT1L, a specific H3K79 methyltransferase, has a tumour‐promoting role in various cancers, including triple‐negative breast cancer (TNBC). However, the…”
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Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes by Vaarla, Krishnaiah, Kesharwani, Rajesh Kumar, Santosh, Karnewar, Vedula, Rajeswar Rao, Kotamraju, Srigiridhar, Toopurani, Murali Krishna

“…[Display omitted] A novel series of coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes (4a–o) were synthesized via an efficient, one-pot…”
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AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation by Gollavilli, Paradesi Naidu, Kanugula, Anantha Koteswararao, Koyyada, Rajeswari, Karnewar, Santosh, Neeli, Praveen Kumar, Kotamraju, Srigiridhar

“…Recent studies have highlighted the involvement of metadherin (MTDH), an oncogenic protein, in promoting cancer progression, metastasis and chemoresistance in…”
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AMPK inhibits MTDH expression via GSK3[beta] and SIRT1 activation: potential role in triple negative breast cancer cell proliferation by Gollavilli, Paradesi Naidu, Kanugula, Anantha Koteswararao, Koyyada, Rajeswari, Karnewar, Santosh, Neeli, Praveen Kumar, Kotamraju, Srigiridhar

“…Recent studies have highlighted the involvement of metadherin (MTDH), an oncogenic protein, in promoting cancer progression, metastasis and chemoresistance in…”
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Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization by Mallappa, Sreevidya, Neeli, Praveen K., Karnewar, Santosh, Kotamraju, Srigiridhar

“…Multidrug resistance mediated by ATP‐binding cassette (ABC) transporters remains a major impediment to cancer chemotherapy. In the present study, we documented…”
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Resveratrol attenuates monocyte-to-macrophage differentiation and associated inflammation via modulation of intracellular GSH homeostasis: Relevance in atherosclerosis by Vasamsetti, Sathish Babu, Karnewar, Santosh, Gopoju, Raja, Gollavilli, Paradesi Naidu, Narra, Sai Ram, Kumar, Jerald Mahesh, Kotamraju, Srigiridhar

“…Monocyte-to-macrophage differentiation promotes an inflammatory environment within the arterial vessel wall that causes a mal-adaptive immune response, which…”
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Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis by Karnewar, Santosh, Vasamsetti, Sathish Babu, Gopoju, Raja, Kanugula, Anantha Koteswararao, Ganji, Sai Krishna, Prabhakar, Sripadi, Rangaraj, Nandini, Tupperwar, Nitin, Kumar, Jerald Mahesh, Kotamraju, Srigiridhar

“…Mitochondria-targeted compounds are emerging as a new class of drugs that can potentially alter the pathophysiology of those diseases where mitochondrial…”
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Mitochondria‐targeted esculetin inhibits PAI‐1 levels by modulating STAT3 activation and miR‐19b via SIRT3: Role in acute coronary artery syndrome by Katta, Sujana, Karnewar, Santosh, Panuganti, Devayani, Jerald, Mahesh Kumar, Sastry, B. K. S., Kotamraju, Srigiridhar

“…In this study we explored the microRNAs responsible for the regulation of PAI‐1 during LPS‐stimulated inflammation in human aortic endothelial cells and…”
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Statin‐induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms by Kanugula, Anantha Koteswararao, Gollavilli, Paradesi Naidu, Vasamsetti, Sathish Babu, Karnewar, Santosh, Gopoju, Raja, Ummanni, Ramesh, Kotamraju, Srigiridhar

“…Accumulating evidence from in vitro, in vivo, clinical and epidemiological studies shows promising results for the use of statins against many cancers…”
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Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations by Aherrahrou, Rédouane, Baig, Ferheen, Theofilatos, Konstantinos, Lue, Dillon, Beele, Alicia, Örd, Tiit, Kaikkonen, Minna U, Aherrahrou, Zouhair, Cheng, Qi, Ghosh, Saikat Kumar B, Karnewar, Santosh, Karnewar, Vaishnavi, Finn, Aloke V, Owens, Gary K, Joner, Michael, Mayr, Manuel, Civelek, Mete

“…Smooth muscle cells (SMCs), which make up the medial layer of arteries, are key cell types involved in cardiovascular disease, the leading cause of mortality…”
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