Search Results - "Karnes, R J"

Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis by Benzon, B, Zhao, S G, Haffner, M C, Takhar, M, Erho, N, Yousefi, K, Hurley, P, Bishop, J L, Tosoian, J, Ghabili, K, Alshalalfa, M, Glavaris, S, Simons, B W, Tran, P, Davicioni, E, Karnes, R J, Boudadi, K, Antonarakis, E S, Schaeffer, E M, Drake, C G, Feng, F, Ross, A E

“…Background: B7-H3 (CD276) , part of the B7 superfamily of immune checkpoint molecules, has been shown to have an immunomodulatory role. Its regulation,…”
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A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy by Ross, A E, Feng, F Y, Ghadessi, M, Erho, N, Crisan, A, Buerki, C, Sundi, D, Mitra, A P, Vergara, I A, Thompson, D J S, Triche, T J, Davicioni, E, Bergstralh, E J, Jenkins, R B, Karnes, R J, Schaeffer, E M

“…Background: Due to their varied outcomes, men with biochemical recurrence (BCR) following radical prostatectomy (RP) present a management dilemma. Here, we…”
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Recurrence, progression and cancer-specific mortality according to stage at re-TUR in T1G3 bladder cancer patients treated with BCG: not as bad as previously thought by Palou, J., Pisano, F., Sylvester, R., Joniau, S., Serretta, V., Larré, S., Di Stasi, S., van Rhijn, B., Witjes, A. J., Grotenhuis, A., Colombo, R., Briganti, A., Babjuk, M., Soukup, V., Malmstrom, P. U., Irani, J., Malats, N., Baniel, J., Mano, R., Cai, T., Cha, E. K., Ardelt, P., Varkarakis, J., Bartoletti, R., Dalbagni, G., Shariat, S. F., Xylinas, E., Karnes, R. J., Gontero, P.

“…Purpose The goals of transurethral resection of a bladder tumor (TUR) are to completely resect the lesions and to make a correct diagnosis to adequately stage…”
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The survival impact of neoadjuvant hormonal therapy before radical prostatectomy for treatment of high-risk prostate cancer by Tosco, L, Laenen, A, Briganti, A, Gontero, P, Karnes, R J, Albersen, M, Bastian, P J, Chlosta, P, Claessens, F, Chun, F K, Everaerts, W, Gratzke, C, Graefen, M, Kneitz, B, Marchioro, G, Salas, R S, Tombal, B, Van den Broeck, T, Moris, L, Battaglia, A, van der Poel, H, Walz, J, Bossi, A, De Meerleer, G, Haustermans, K, Van Poppel, H, Spahn, M, Joniau, S

“…Background: Several randomized controlled trials assessed the outcomes of patients treated with neoadjuvant hormonal therapy (NHT) before radical prostatectomy…”
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Predictors of oncological outcomes in T1G3 patients treated with BCG who undergo radical cystectomy by Soria, Francesco, Pisano, Francesca, Gontero, Paolo, Palou, J., Joniau, S., Serretta, V., Larré, S., Di Stasi, S., van Rhijn, B., Witjes, J. A., Grotenhuis, A., Colombo, R., Briganti, A., Babjuk, M., Soukup, V., Malmstrom, P. U., Irani, J., Malats, N., Baniel, J., Mano, R., Cai, T., Cha, E., Ardelt, P., Varkarakis, J., Bartoletti, R., Dalbagni, G., Shariat, S. F., Xylinas, E., Karnes, R. J., Sylvester, R.

“…Purpose To evaluate the oncological impact of postponing radical cystectomy (RC) to allow further conservative therapies prior to progression in a large…”
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Carcinosarcoma of the Prostate Replacing the Entire Lower Genitourinary Tract by McGee, Shawn M, Boorjian, Stephen A, Karnes, R.J

“…Less than 100 cases of prostate carcinosarcoma have been described in published studies. Most of these cases describe symptoms due to bladder outlet…”
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Use of tumor dynamics to clarify the observed variability among biochemical recurrence nomograms for prostate cancer by Dimonte, Guy, Bergstralh, E.J., Bolander, M.E., Karnes, R.J., Tindall, D.J.

“…BACKGROUND Nomograms for biochemical recurrence (BCR) of prostate cancer (PC) after radical prostatectomy can yield very different prognoses for individual…”
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Role of Lymphadenectomy during Radical Cystectomy for Nonmuscle-Invasive Bladder Cancer: Results from a Multi-Institutional Experience by Khanna, Abhinav, Miest, Tanner, Sharma, Vidit, Campbell, Rebecca, Hensley, Patrick, Thapa, Prabin, Zganjar, Andrew, Tollefson, Matthew K, Thompson, R Houston, Frank, Igor, Karnes, R J, Murthy, Prithvi B, Haber, Georges P, Navai, Neema, Kamat, Ashish M, Dinney, Colin, Lee, Byron, Boorjian, Stephen A

“…While lymph node dissection (LND) at radical cystectomy (RC) for muscle-invasive bladder cancer has been studied extensively, the role of LND for…”
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Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality by Tse, B W C, Volpert, M, Ratther, E, Stylianou, N, Nouri, M, McGowan, K, Lehman, M L, McPherson, S J, Roshan-Moniri, M, Butler, M S, Caradec, J, Gregory-Evans, C Y, McGovern, J, Das, R, Takhar, M, Erho, N, Alshalafa, M, Davicioni, E, Schaeffer, E M, Jenkins, R B, Ross, A E, Karnes, R J, Den, R B, Fazli, L, Gregory, P A, Gleave, M E, Williams, E D, Rennie, P S, Buttyan, R, Gunter, J H, Selth, L A, Russell, P J, Nelson, C C, Hollier, B G

“…Recent evidence has implicated the transmembrane co-receptor neuropilin-1 (NRP1) in cancer progression. Primarily known as a regulator of neuronal guidance and…”
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Standard of Care Versus Metastases-directed Therapy for PET-detected Nodal Oligorecurrent Prostate Cancer Following Multimodality Treatment: A Multi-institutional Case-control Study by Steuber, T., Jilg, C., Tennstedt, P., De Bruycker, A., Tilki, D., Decaestecker, K., Zilli, T., Jereczek-Fossa, B.A., Wetterauer, U., Grosu, A.L., Schultze-Seemann, W., Heinzer, H., Graefen, M., Morlacco, A., Karnes, R.J., Ost, P.

“…Most prostate cancer (PCa) patients with a biochemical failure following primary multimodality treatment (surgery and postoperative radiotherapy) relapse in…”
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Development and Validation of a Risk-Adapted Scoring Model for Metachronous Upper Tract Urothelial Carcinoma following Radical Cystectomy by Miest, T, Khanna, A, Sharma, V, Hensley, P J, Campbell, R, Thapa, P, Zganjar, A, Tollefson, M K, Thompson, R H, Frank, I, Karnes, R J, Potretzke, A, Matin, S F, Murthy, P B, Haber, G P, Lee, B, Boorjian, S A

“…The incidence and risk factors for metachronous upper tract urothelial carcinoma (UTUC) following radical cystectomy (RC) remain incompletely defined, which…”
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Treatment of M1a/M1b prostate cancer with or without radical prostatectomy at diagnosis by Moschini, M, Morlacco, A, Kwon, E, Rangel, L J, Karnes, R J

“…BACKGROUND: The aim of the study was to evaluate survival and perioperative outcomes of metastatic prostate cancer (mPCa) patients treated with surgery or…”
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Patterns and prognostic significance of clinical recurrences after radical cystectomy for bladder cancer: A 20-year single center experience by Moschini, M, Karnes, R.J, Sharma, V, Gandaglia, G, Fossati, N, Dell'Oglio, P, Cucchiara, V, Capogrosso, P, Shariat, S.F, Damiano, R, Salonia, A, Montorsi, F, Briganti, A, Gallina, A, Colombo, R

“…Abstract Objective Patients treated with radical cystectomy (RC) due to bladder cancer (BCa) face high risk of clinical recurrence. The aim of our study was to…”
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Impact of Neoadjuvant Chemotherapy on Pathologic Downstaging in Patients With Variant Histology Undergoing Radical Cystectomy by Campbell, Rebecca A., Khanna, Abhinav, Boorjian, Stephen A., Knorr, Jacob, Cox, Roni, Nicholas, Marlo, Cheville, John, Sharma, Vidit, Murthy, Prithvi B., Tarrell, Robert, Thapa, Prabin, Tollefson, Matthew K., Thompson, R. Houston, Frank, Igor, Karnes, R.J., Haber, Georges Pascal, Lee, Byron

“…Variant histology (VH) bladder cancer is often associated with poor outcomes and the role of neoadjuvant chemotherapy (NAC) remains incompletely defined. Our…”
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Double-blind placebo controlled study of alpha-adrenergic receptor antagonists (doxazosin) for treatment of voiding dysfunction in the pediatric population by Kramer, S A, Rathbun, S R, Elkins, D, Karnes, R J, Husmann, D A

“…We sought to determine whether the alpha-adrenergic antagonist doxazosin could be used as primary therapy in children with voiding dysfunction. Children were…”
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A urine-based methylation signature for risk stratification within low-risk prostate cancer by Jatkoe, T A, Karnes, R J, Freedland, S J, Wang, Y, Le, A, Baden, J

“…Background: Prostate cancer overdiagnosis and overtreatment represents a major problem. Many men with low-grade disease on biopsy are undergraded and they…”
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Association between neuraxial analgesia, cancer progression, and mortality after radical prostatectomy: a large, retrospective matched cohort study by Scavonetto, F., Yeoh, T.Y., Umbreit, E.C., Weingarten, T.N., Gettman, M.T., Frank, I., Boorjian, S.A., Karnes, R.J., Schroeder, D.R., Rangel, L.J., Hanson, A.C., Hofer, R.E., Sessler, D.I., Sprung, J.

“…Systemic opioids are immunosuppressive, which could promote tumour recurrence. We, therefore, test the hypothesis that supplementing general anaesthesia with…”
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Early detection of prostate cancer relapse by biochemistry and diagnostic imaging by Evangelista, L, Zattoni, F, Rossi, E, Karnes, R J, Lowe, V

“…Prostate cancer (PCa) is a common malignancy in men associated with an increase in the incidence rate. Radical prostatectomy (RP) or external beam radiotherapy…”
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The association of tumor volume with mortality following radical prostatectomy by Knoedler, J J, Karnes, R J, Thompson, R H, Rangel, L J, Bergstralh, E J, Boorjian, S A

“…Background: Data regarding the prognostic significance of tumor volume (TV) in prostate cancer are conflicting. Herein, we evaluated the association of TV with…”
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Atypical small acinar proliferation (ASAP): Is a repeat biopsy necessary ASAP? A multi-institutional review by Leone, A, Gershman, B, Rotker, K, Butler, C, Fantasia, J, Miller, A, Afiadata, A, Amin, A, Zhou, A, Jiang, Z, Sebo, T, Mega, A, Schiff, S, Pareek, G, Golijanin, D, Yates, J, Karnes, R J, Renzulli, J

“…Background: Atypical small acinar proliferation (ASAP) occurs in approximately 5% of prostate biopsies. Approximately 30–40% of patients with ASAP may develop…”
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