Search Results - "Karnes, Jason"

Pharmacogenetics to prevent heparin-induced thrombocytopenia: what do we know? by Karnes, Jason H

“…Heparin-induced thrombocytopenia (HIT) is a life-threatening, immune-mediated adverse reaction to heparin anticoagulants. The inability to predict HIT…”
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From Big Data to Precision Medicine by Hulsen, Tim, Jamuar, Saumya S, Moody, Alan R, Karnes, Jason H, Varga, Orsolya, Hedensted, Stine, Spreafico, Roberto, Hafler, David A, McKinney, Eoin F

“…For over a decade the term "Big data" has been used to describe the rapid increase in volume, variety and velocity of information available, not just in…”
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA‐B Genotypes and Phenytoin Dosing: 2020 Update by Karnes, Jason H., Rettie, Allan E., Somogyi, Andrew A., Huddart, Rachel, Fohner, Alison E., Formea, Christine M., Ta Michael Lee, Ming, Llerena, Adrian, Whirl‐Carrillo, Michelle, Klein, Teri E., Phillips, Elizabeth J., Mintzer, Scott, Gaedigk, Andrea, Caudle, Kelly E., Callaghan, John T.

“…Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in…”
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Comparison of HLA allelic imputation programs by Karnes, Jason H, Shaffer, Christian M, Bastarache, Lisa, Gaudieri, Silvana, Glazer, Andrew M, Steiner, Heidi E, Mosley, Jonathan D, Mallal, Simon, Denny, Joshua C, Phillips, Elizabeth J, Roden, Dan M

“…Imputation of human leukocyte antigen (HLA) alleles from SNP-level data is attractive due to importance of HLA alleles in human disease, widespread…”
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Immunopharmacogenomics: Mechanisms of HLA‐Associated Drug Reactions by Deshpande, Pooja, Hertzman, Rebecca J., Palubinsky, Amy M., Giles, Jason B., Karnes, Jason H., Gibson, Andrew, Phillips, Elizabeth J.

“…The human leukocyte antigen (HLA) system is the most polymorphic in the human genome that has been associated with protection and predisposition to a broad…”
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Warfarin Pharmacogenomics in Diverse Populations by Kaye, Justin B., Schultz, Lauren E., Steiner, Heidi E., Kittles, Rick A., Cavallari, Larisa H., Karnes, Jason H.

“…Genotype‐guided warfarin dosing algorithms are a rational approach to optimize warfarin dosing and potentially reduce adverse drug events. Diverse populations,…”
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Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project by Karnes, Jason H, Arora, Amit, Feng, Jianglin, Steiner, Heidi E, Sulieman, Lina, Boerwinkle, Eric, Clark, Cheryl, Cicek, Mine, Cohn, Elizabeth, Gebo, Kelly, Loperena-Cortes, Roxana, Ohno-Machado, Lucila, Mayo, Kelsey, Mockrin, Steve, Ramirez, Andrea, Schully, Sheri, Klimentidis, Yann C

“…Differences in obesity and body fat distribution across gender and race/ethnicity have been extensively described. We sought to replicate these differences and…”
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Reply to Non and Chang: Challenging the Role of Genetic Ancestry in Explaining Racial/Ethnic Health Disparities by Karnes, Jason H, Schwantes-An, Tae-Hwi, Kittles, Rick, Desai, Ankit A

“…Karnes et al respond to Non and Chang about challenging the role of genetic ancestry in explaining racial/ethic health disparities in pulmonary arterial…”
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Role of the gut microbiome in cardiovascular drug response: The potential for clinical application by Steiner, Heidi E., Gee, Kevin, Giles, Jason, Knight, Hayley, Hurwitz, Bonnie L, Karnes, Jason H.

“…Response to cardiovascular drugs can vary greatly between individuals, and the role of the microbiome in this variability is being increasingly appreciated…”
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PharmGKB summary: heparin-induced thrombocytopenia pathway, adverse drug reaction by Miller, Elise, Norwood, Charles, Giles, Jason B., Huddart, Rachel, Karnes, Jason H., Whirl-Carrillo, Michelle, Klein, Teri E.

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Cost-effectiveness of anticoagulants for suspected heparin-induced thrombocytopenia in the United States by Aljabri, Ahmed, Huckleberry, Yvonne, Karnes, Jason H., Gharaibeh, Mahdi, Kutbi, Hussam I., Raz, Yuval, Yun, Seongseok, Abraham, Ivo, Erstad, Brian

“…Despite the availability of multiple nonheparin anticoagulants for the treatment of heparin-induced thrombocytopenia (HIT), few data are available comparing…”
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Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions by Karnes, Jason H, Miller, Matthew A, White, Katie D, Konvinse, Katherine C, Pavlos, Rebecca K, Redwood, Alec J, Peter, Jonathan G, Lehloenya, Rannakoe, Mallal, Simon A, Phillips, Elizabeth J

“…Adverse drug reactions (ADRs) are a significant health care burden. Immune-mediated adverse drug reactions (IM-ADRs) are responsible for one-fifth of ADRs but…”
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension by Tai, Yi-Yin, Yu, Qiujun, Tang, Ying, Sun, Wei, Kelly, Neil J, Okawa, Satoshi, Zhao, Jingsi, Schwantes-An, Tae-Hwi, Lacoux, Caroline, Torrino, Stephanie, Al Aaraj, Yassmin, El Khoury, Wadih, Negi, Vinny, Liu, Mingjun, Corey, Catherine G, Belmonte, Frances, Vargas, Sara O, Schwartz, Brian, Bhat, Bal, Chau, B Nelson, Karnes, Jason H, Satoh, Taijyu, Barndt, Robert J, Wu, Haodi, Parikh, Victoria N, Wang, Jianrong, Zhang, Yingze, McNamara, Dennis, Li, Gang, Speyer, Gil, Wang, Bing, Shiva, Sruti, Kaufman, Brett, Kim, Seungchan, Gomez, Delphine, Mari, Bernard, Cho, Michael H, Boueiz, Adel, Pauciulo, Michael W, Southgate, Laura, Trembath, Richard C, Sitbon, Olivier, Humbert, Marc, Graf, Stefan, Morrell, Nicholas W, Rhodes, Christopher J, Wilkins, Martin R, Nouraie, Mehdi, Nichols, William C, Desai, Ankit A, Bertero, Thomas, Chan, Stephen Y

“…Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial…”
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Planning and Conducting a Pharmacogenetics Association Study by Hertz, Daniel L., Arwood, Meghan J., Stocco, Gabriele, Singh, Sonal, Karnes, Jason H., Ramsey, Laura B.

“…Pharmacogenetics (PGx) association studies are used to discover, replicate, and validate the association between an inherited genotype and a treatment outcome…”
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Visualization and Quantification of the Association Between Breast Cancer and Cholesterol in the All of Us Research Program by Feng, Jianglin, Symonds, Esteban Astiazaran, Karnes, Jason H

“…Epidemiologic evidence for the association of cholesterol and breast cancer is inconsistent. Several factors may contribute to this inconsistency, including…”
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Disparities in ABO blood type determination across diverse ancestries: a systematic review and validation in the All of Us Research Program by Martinez, Kiana L, Klein, Andrew, Martin, Jennifer R, Sampson, Chinwuwanuju U, Giles, Jason B, Beck, Madison L, Bhakta, Krupa, Quatraro, Gino, Farol, Juvie, Karnes, Jason H

“…ABO blood types have widespread clinical use and robust associations with disease. The purpose of this study is to evaluate the portability and suitability of…”
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SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics by Sangam, Shreya, Sun, Xutong, Schwantes-An, Tae-Hwi, Yegambaram, Manivannan, Lu, Qing, Shi, Yinan, Cook, Todd, Fisher, Amanda, Frump, Andrea L, Coleman, Anna, Sun, Yanan, Liang, Shuxin, Crawford, Howard, Lutz, Katie A, Maun, Avinash D, Pauciulo, Michael W, Karnes, Jason H, Chaudhary, Ketul R, Stewart, Duncan J, Langlais, Paul R, Jain, Mohit, Alotaibi, Mona, Lahm, Tim, Jin, Yan, Gu, Haiwei, Tang, Haiyang, Nichols, William C, Black, Stephen M, Desai, Ankit A

“…Genetic studies suggest that SOX17 (SRY-related HMG-box 17) deficiency increases pulmonary arterial hypertension (PAH) risk. On the basis of pathological roles…”
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Genome-Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor by Bime, Christian, Pouladi, Nima, Sammani, Saad, Batai, Ken, Casanova, Nancy, Zhou, Tong, Kempf, Carrie L, Sun, Xiaoguang, Camp, Sara M, Wang, Ting, Kittles, Rick A, Lussier, Yves A, Jones, Tiffanie K, Reilly, John P, Meyer, Nuala J, Christie, Jason D, Karnes, Jason H, Gonzalez-Garay, Manuel, Christiani, David C, Yates, Charles R, Wurfel, Mark M, Meduri, Gianfranco U, Garcia, Joe G N

“…Genetic factors are involved in acute respiratory distress syndrome (ARDS) susceptibility. Identification of novel candidate genes associated with increased…”
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Elucidation of Cellular Contributions to Heparin-Induced Thrombocytopenia Using Omic Approaches by Giles, Jason B, Miller, Elise C, Steiner, Heidi E, Karnes, Jason H

“…Heparin-induced thrombocytopenia (HIT) is an unpredictable, complex, immune-mediated adverse drug reaction associated with a high mortality. Despite decades of…”
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Biobanks and electronic medical records: enabling cost-effective research by Bowton, Erica, Field, Julie R, Wang, Sunny, Schildcrout, Jonathan S, Van Driest, Sara L, Delaney, Jessica T, Cowan, James, Weeke, Peter, Mosley, Jonathan D, Wells, Quinn S, Karnes, Jason H, Shaffer, Christian, Peterson, Josh F, Denny, Joshua C, Roden, Dan M, Pulley, Jill M

“…The use of electronic medical record data linked to biological specimens in health care settings is expected to enable cost-effective and rapid genomic…”
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