Search Results - "Karmaus, Peer W"

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming by Yang, Kai, Shrestha, Sharad, Zeng, Hu, Karmaus, Peer W.F., Neale, Geoffrey, Vogel, Peter, Guertin, David A., Lamb, Richard F., Chi, Hongbo

“…Naive T cells respond to antigen stimulation by exiting from quiescence and initiating clonal expansion and functional differentiation, but the control…”
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CD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation by Izumi, Gentaro, Nakano, Hideki, Nakano, Keiko, Whitehead, Gregory S., Grimm, Sara A., Fessler, Michael B., Karmaus, Peer W., Cook, Donald N.

“…Dendritic cells (DC) in the lung that induce Th17 differentiation remain incompletely understood, in part because conventional CD11b + DCs (cDC2) are…”
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Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells by Du, Xingrong, Wen, Jing, Wang, Yanyan, Karmaus, Peer W. F., Khatamian, Alireza, Tan, Haiyan, Li, Yuxin, Guy, Cliff, Nguyen, Thanh-Long M., Dhungana, Yogesh, Neale, Geoffrey, Peng, Junmin, Yu, Jiyang, Chi, Hongbo

“…Dendritic cells orchestrate the crosstalk between innate and adaptive immunity. CD8α + dendritic cells present antigens to CD8 + T cells and elicit cytotoxic T…”
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Tsc1 promotes the differentiation of memory CD8⁺ T cells via orchestrating the transcriptional and metabolic programs by Shrestha, Sharad, Yang, Kai, Wei, Jun, Karmaus, Peer W. F., Neale, Geoffrey, Chi, Hongbo

“…Significance Enhancing the generation and function of memory T cells represents a crucial strategy to improve protective immunity against pathogens and tumors…”
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Race-specific association of an IRGM risk allele with cytokine expression in human subjects by Ajayi, Teminioluwa, Rai, Prashant, Shi, Min, Gabor, Kristin A., Karmaus, Peer W. F., Meacham, Julie M., Katen, Kevin, Madenspacher, Jennifer H., Schurman, Shepherd H., Fessler, Michael B.

“…Immunity-related GTPase family M ( IRGM ), located on human chromosome 5q33.1, encodes a protein that promotes autophagy and suppresses the innate immune…”
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IRGM1 links mitochondrial quality control to autoimmunity by Rai, Prashant, Janardhan, Kyathanahalli S., Meacham, Julie, Madenspacher, Jennifer H., Lin, Wan-Chi, Karmaus, Peer W. F., Martinez, Jennifer, Li, Quan-Zhen, Yan, Mei, Zeng, Jialiu, Grinstaff, Mark W., Shirihai, Orian S., Taylor, Gregory A., Fessler, Michael B.

“…Mitochondrial abnormalities have been noted in lupus, but the causes and consequences remain obscure. Autophagy-related genes ATG5 , ATG7 and IRGM have been…”
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mTOR and metabolic regulation of conventional and regulatory T cells by Liu, Chaohong, Chapman, Nicole M., Karmaus, Peer W. F., Zeng, Hu, Chi, Hongbo

“…Review of regulation of mTOR signaling in T cells, and roles of mTOR and metabolic pathways in conventional and regulatory T cells. mTOR signaling links…”
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Genetic dissection of dendritic cell homeostasis and function: lessons from cell type-specific gene ablation by Karmaus, Peer W. F, Chi, Hongbo

“…Dendritic cells (DCs) are a heterogeneous cell population of great importance in the immune system. The emergence of new genetic technology utilizing the CD11c…”
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Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis by Karmaus, Peer W F, Herrada, Andrés A, Guy, Cliff, Neale, Geoffrey, Dhungana, Yogesh, Long, Lingyun, Vogel, Peter, Avila, Julian, Clish, Clary B, Chi, Hongbo

“…Myelopoiesis is necessary for the generation of mature myeloid cells during homeostatic turnover and immunological insults; however, the metabolic requirements…”
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25-Hydroxycholesterol exacerbates vascular leak during acute lung injury by Madenspacher, Jennifer H, Morrell, Eric D, McDonald, Jeffrey G, Thompson, Bonne M, Li, Yue, Birukov, Konstantin G, Birukova, Anna A, Stapleton, Renee D, Alejo, Aidin, Karmaus, Peer W, Meacham, Julie M, Rai, Prashant, Mikacenic, Carmen, Wurfel, Mark M, Fessler, Michael B

“…Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung…”
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DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer by Li, Wenling, Nakano, Hideki, Fan, Wei, Li, Yuanyuan, Sil, Payel, Nakano, Keiko, Zhao, Fei, Karmaus, Peer W, Grimm, Sara A, Shi, Min, Xu, Xin, Mizuta, Ryushin, Kitamura, Daisuke, Wan, Yisong, Fessler, Michael B, Cook, Donald N, Shats, Igor, Li, Xiaoling, Li, Leping

“…DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3…”
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Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection by Karmaus, Peer W. F., Chen, Weimin, Crawford, Robert B., Harkema, Jack R., Kaplan, Barbara L. F., Kaminski, Norbert E.

“…Deletion of cannabinoid receptors 1 and 2 causes increased sensitivity to immune activation in APC, thereby exacerbating inflammation and cellular immune…”
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Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma by Lee, Eunice Y, Choi, Wonson, Burkholder, Adam B, Perera, Lalith, Mack, Jasmine A, Miller, Frederick W, Fessler, Michael B, Cook, Donald N, Karmaus, Peer W F, Nakano, Hideki, Garantziotis, Stavros, Madenspacher, Jennifer H, House, John S, Akhtari, Farida S, Schmitt, Charles S, Fargo, David C, Hall, Janet E, Motsinger-Reif, Alison A

“…Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the…”
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Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells by Fang, Yi, Xu, Xiaojiang, Ding, Jun, Yang, Lu, Doan, Mary T., Karmaus, Peer W.F., Snyder, Nathaniel W., Zhao, Yingming, Li, Jian-Liang, Li, Xiaoling

“…Histone crotonylation is a non-acetyl histone lysine modification that is as widespread as acetylation. However, physiological functions associated with…”
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Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity by Karmaus, Peer W. F., Chen, Xiang, Lim, Seon Ah, Herrada, Andrés A., Nguyen, Thanh-Long M., Xu, Beisi, Dhungana, Yogesh, Rankin, Sherri, Chen, Wenan, Rosencrance, Celeste, Yang, Kai, Fan, Yiping, Cheng, Yong, Easton, John, Neale, Geoffrey, Vogel, Peter, Chi, Hongbo

“…A defining feature of adaptive immunity is the development of long-lived memory T cells to curtail infection. Recent studies have identified a unique stem-like…”
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Meta-Analysis of COVID-19 BAL Single-Cell RNA Sequencing Reveals Alveolar Epithelial Transitions and Unique Alveolar Epithelial Cell Fates by Karmaus, Peer W F, Tata, Aleksandra, Meacham, Julie M, Day, Frank, Thrower, David, Tata, Purushothama Rao, Fessler, Michael B

“…Single-cell RNA sequencing (scRNA-seq) of BAL cells has provided insights into coronavirus disease (COVID-19). However, reports have been limited by small…”
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CD9 and Aryl Hydrocarbon Receptor Are Markers of Human CD19+CD14+ Atypical B Cells and Are Dysregulated in Systemic Lupus Erythematous Disease by Blevins, Lance K, Khan, D M Isha Olive, Crawford, Robert B, O'Neill, Christine, Bach, Anthony P, Zhou, Jiajun, Karmaus, Peer W, Ang, Dennis C, Thapa, Rupak, Kaminski, Norbert E

“…Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor whose expression regulates immune cell differentiation. Single-cell transcriptomic…”
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Application of single cell methods in immunometabolism and immunotoxicology by Karmaus, Peer W.F.

“…Recent developments of novel single-cell analysis techniques have rapidly advanced the fields of immunotoxicology and immunometabolism. Single-cell analyses…”
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The Effects of Targeted Deletion of Cannabinoid Receptors CB1 and CB2 on Intranasal Sensitization and Challenge with Adjuvant-free Ovalbumin by Kaplan, Barbara L. F., Lawver, Jody E., Karmaus, Peer W. F., Ngaotepprutaram, Thitirat, Birmingham, Neil P., Harkema, Jack R., Kaminski, Norbert E.

“…The mechanisms by which cannabinoid receptors CB1 and CB2 modulate immune function are not fully elucidated. Critical tools for the determination of the role…”
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Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway by Ting, Kenneth K Y, Yu, Pei, Dow, Riley, Floro, Eric, Ibrahim, Hisham, Scipione, Corey A, Hyduk, Sharon J, Polenz, Chanele K, Zaslaver, Olga, Karmaus, Peer W F, Fessler, Michael B, Röst, Hannes L, Ohh, Michael, Tsai, Sue, Winer, Daniel A, Woo, Minna, Rocheleau, Jonathan, Jongstra-Bilen, Jenny, Cybulsky, Myron I

“…Lipid accumulation in macrophages (Mφs) is a hallmark of atherosclerosis, yet how lipid accumulation affects inflammatory responses through rewiring of Mφ…”
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