Search Results - "Karlgren, M"

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box by Karlgren, M, Simoff, I, Keiser, M, Oswald, S, Artursson, P

“…Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9), i.e., CRISPR-Cas9, has been extensively used as a…”
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Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach by Vildhede, Anna, Mateus, André, Khan, Elin K, Lai, Yurong, Karlgren, Maria, Artursson, Per, Kjellsson, Maria C

“…Isolated human hepatocytes are commonly used to predict transporter-mediated clearance in vivo. Such predictions, however, do not provide estimations of…”
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Novel extrahepatic cytochrome P450s by Karlgren, Maria, Miura, Shin-ichi, Ingelman-Sundberg, Magnus

“…The cytochrome P450 enzymes are highly expressed in the liver and are involved in the metabolism of xenobiotics. Because of the initiatives associated with the…”
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids by Mickols, Evgeniya, Meyer, Alina, Handin, Niklas, Stüwe, Malin, Eriksson, Jens, Rudfeldt, Jakob, Blom, Kristin, Fryknäs, Mårten, Sellin, Mikael E., Lauschke, Volker M., Karlgren, Maria, Artursson, Per

“…3D spheroids of primary human hepatocytes (3D PHH) retain a differentiated phenotype with largely conserved metabolic function and proteomic fingerprint over…”
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A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability by Vallianatou, Theodosia, Strittmatter, Nicole, Nilsson, Anna, Shariatgorji, Mohammadreza, Hamm, Gregory, Pereira, Marcela, Källback, Patrik, Svenningsson, Per, Karlgren, Maria, Goodwin, Richard J.A., Andrén, Per E.

“…There is a high need to develop quantitative imaging methods capable of providing detailed brain localization information of several molecular species…”
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Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain by Vallianatou, Theodosia, Shariatgorji, Reza, Nilsson, Anna, Karlgren, Maria, Hulme, Heather, Fridjonsdottir, Elva, Svenningsson, Per, Andrén, Per E

“…Detailed metabolic imaging of specific brain regions in early aging may expose pathophysiological mechanisms and indicate effective neuropharmacological…”
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Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment by Rodriguez-Antona, Cristina, Gomez, Alvin, Karlgren, Maria, Sim, Sarah C, Ingelman-Sundberg, Magnus

“…The cytochromes P450 (CYPs) are very efficient catalysts of foreign compound metabolism and are responsible for the major part of metabolism of clinically…”
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Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells by Pellegrini, Paola, Dyczynski, Matheus, Sbrana, Francesca Vittoria, Karlgren, Maria, Buoncervello, Maria, Hägg-Olofsson, Maria, Ma, Ran, Hartman, Johan, Bajalica-Lagercrantz, Svetlana, Grander, Dan, Kharaziha, Pedram, De Milito, Angelo

“…Sustained autophagy contributes to the metabolic adaptation of cancer cells to hypoxic and acidic microenvironments. Since cells in such environments are…”
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The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer – A pilot study by Edler, David, Stenstedt, Kristina, Öhrling, Katarina, Hallström, Marja, Karlgren, Maria, Ingelman-Sundberg, Magnus, Ragnhammar, Peter

“…Abstract Aim Cytochrome P450 (CYP) enzymes are important for drug metabolism. A novel cytochrome P450 enzyme, CYP2W1, has recently been identified. This enzyme…”
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An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux by Neve, Etienne P. A, Artursson, Per, Ingelman-Sundberg, Magnus, Karlgren, Maria

“…The absorption, distribution, metabolism, and excretion (ADME) of drugs in vivo are to a large extent dependent on different transport and metabolism routes…”
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Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1 by Karlgren, Maria, Gomez, Alvin, Stark, Katarina, Svärd, Jenny, Rodriguez-Antona, Cristina, Oliw, Ernst, Bernal, Maria Luisa, y Cajal, Santiago Ramón, Johansson, Inger, Ingelman-Sundberg, Magnus

“…A novel human cytochrome P450, CYP2W1, was cloned and expressed heterologously. No or very low CYP2W1 mRNA levels were detected in fetal and adult human…”
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Expression of CYP2W1 in colon tumors: regulation by gene methylation by Gomez, Alvin, Karlgren, Maria, Edler, David, Bernal, Maria Luisa, Mkrtchian, Souren, Ingelman-Sundberg, Magnus

“…CYP2W1 is a novel enzyme shown to be selectively expressed in rat fetal colon and in human colon cancer and has previously been suggested as a potential drug…”
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A study of the efficiency of shared attraction memories in cluster-based COMA multiprocessors by Landin, A., Karlgren, M.

“…The performance of a COMA multiprocessor greatly depends on the efficiency of the large node caches, the attraction memories. When more than one processor…”
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Tumour-specific expression of CYP2W1: its potential as a drug target in cancer therapy by Karlgren, Maria, Ingelman-Sundberg, Magnus

“…Recently, a new cytochrome P450, designated CYP2W1, was identified. This enzyme is expressed in transformed tissues and during fetal life, whereas in human…”
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Characterization and tissue distribution of a novel human cytochrome P450—CYP2U1 by Karlgren, Maria, Backlund, Maria, Johansson, Inger, Oscarson, Mikael, Ingelman-Sundberg, Magnus

“…A novel human cytochrome P450 cDNA designated CYP2U1 was identified using homology searches, and the corresponding gene is located on chromosome 4. The deduced…”
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Tumor specific expression of the novel cytochrome P450 enzyme CYP2W1 by Karlgren, M, Gomez, A, Ingelman-Sundberg, M

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Novel extrahepatic cytochrome P450s by Karlgren, M, Oscarson, M, Ingelman-Sundberg, M

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A novel human cytochrome p450 enzyme, CYP2W1. analysis of function and distribution by Karlgren, M, Stark, K, Oliw, E, Ingelman-Sundberg, M

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GENETIC POLYMORPHISMS AND HAPLOTYPE STRUCTURES OF THE CYP2W1 GENE IN A JAPANESE POPULATION by Hiratsuka, M, Hanzawa, Y, Sasaki, T, Sakuyama, K, Ishikawa, M, Mizugaki, M, Karlgren, M, Tachibana, M, Gomez, A, Ingelman-Sundberg, M

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DNA methylation governs the expression of CYP2W1 by Gomez, A, Rodriguez-Antona, C, Mkrtchian, S, Karlgren, M, Ingelman-Sundberg, M

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