Search Results - "Karle, I. L"

Structural characteristics of .alpha.-helical peptide molecules containing Aib residues by Karle, Isabella L, Balaram, Padmanabhan

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ω-Amino Acids in Peptide Design. Crystal Structures and Solution Conformations of Peptide Helices Containing a β-Alanyl-γ-Aminobutyryl Segment by Karle, I. L, Pramanik, Animesh, Banerjee, Arindam, Bhattacharjya, Surajit, Balaram, P

“…Insertion of achiral ω-amino acids into peptide sequences results in replacement of scissile peptide bonds by proteolytically stable C−C bonds. This provides a…”
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A Designed β -Hairpin Peptide in Crystals by Karle, Isabella L., Awasthi, Satish K., Balaram, Padmanabhan

“…β -hairpin structures have been crystallographically characterized only in very short acyclic peptides, in contrast to helices. The structure of the designed β…”
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Folding, aggregation and molecular recognition in peptides by Karle, I L

“…In past years, most of the X-ray structure determinations of oligopeptides were for cyclic peptides or for short linear peptides. Longer peptides usually…”
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Comparison of helix-stabilizing effects of α,α-dialkyl glycines with linear and cycloalkyl side chains by Vijayalakshmi, S., Rao, R. Balaji, Karle, I. L., Balaram, P.

“…The ability of α,α‐di‐n‐alkyl glycines with linear and cyclic alkyl side chains to stabilize helical conformations has been compared using a model heptapeptide…”
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Crystal structure of [Leu1]zervamicin, a membrane ion-channel peptide: implications for gating mechanisms by Karle, I L, Flippen-Anderson, J L, Agarwalla, S, Balaram, P

“…Structures in four different crystal forms of [Leu1]zervamicin (zervamicin Z-L, Ac-Leu-Ile-Gln-Iva-Ile5-Thr-Aib-Leu-Aib-Hyp10-Gln-Aib-Hyp-Aib-P ro15-Phol,…”
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Self-Assembling, Cystine-Derived, Fused Nanotubes Based on Spirane Architecture:  Design, Synthesis, and Crystal Structure of Cystinospiranes by Ranganathan, Darshan, Samant, Manoj P, Karle, Isabella L

“…A novel family of cystine-based spirobicyclic peptides (cystinospiranes) has been synthesized by a single-step procedure involving condensation of…”
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Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum by Karle, J M, Karle, I L, Gerena, L, Milhous, W K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Conformation of a 16-residue zervamicin IIA analog peptide containing three different structural features: 3(10)-helix, alpha-helix, and beta-bend ribbon by Karle, I L, Flippen-Anderson, J, Sukumar, M, Balaram, P

“…Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-Ala-Aib-Pro-Aib-Pro-Phe-OMe (where Boc is t-butoxycarbonyl and Aib is alpha-aminoisobutyric acid), a synthetic…”
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Controls exerted by the Aib residue: Helix formation and helix reversal by Karle, Isabella L.

“…The helix forming properties of the achiral α‐amino isobutyric residue (Aib) have been demonstrated by numerous crystal structure analyses of designed and…”
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Crystal structure and molecular structure of mefloquine methylsulfonate monohydrate: implications for a malaria receptor by KARLE, J. M, KARLE, I. L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Alpha-helix and mixed 3(10)/alpha-helix in cocrystallized conformers of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe by Karle, I L, Flippen-Anderson, J L, Uma, K, Balaram, H, Balaram, P

“…Two molecules of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe (where Boc is t-butoxycarbonyl and Aib is alpha-aminoisobutyryl) cocrystallize in a triclinic…”
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Aqueous channels within apolar peptide aggregates: solvated helix of the alpha-aminoisobutyric acid (Aib)-containing peptide Boc-(Aib-Ala-Leu)3-Aib-OMe.2H2O.CH3OH in crystals by Karle, I L, Flippen-Anderson, J, Uma, K, Balaram, P

“…Although the peptide Boc-Aib1-Ala2-Leu3-Aib4-Ala5-Leu6-Aib7-Ala8-L eu9-Aib10-OME [with a t-butoxycarbonyl (Boc) blocking group at the amino terminus, a methyl…”
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Unfolding of an alpha-helix in peptide crystals by solvation: conformational fragility in a heptapeptide by Karle, I L, Flippen-Anderson, J L, Uma, K, Balaram, P

“…The structure of the peptide Boc-Val-Ala-Leu-Aib-Val-Ala-Leu-OMe has been determined in crystals obtained from a dimethylsulfoxide-isopropanol mixture. Crystal…”
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Ion channel formation by zervamicin-IIB : a molecular modelling study by SANSOM, M. S. P, BALARAM, P, KARLE, I. L

“…Zervamicin-IIB (Zrv-IIB) is a 16 residue peptaibol which forms voltage-activated, multiple conductance level channels in planar lipid bilayers. A molecular…”
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Parallel packing of alpha-helices in crystals of the zervamicin IIA analog Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe.2H2O by Karle, I L, Sukumar, M, Balaram, P

“…An apolar synthetic analog of the first 10 residues at the NH2-terminal end of zervamicin IIA crystallizes in the triclinic space group P1 with cell dimensions…”
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Zervamicins, a structurally characterised peptide model for membrane ion channels by Agarwalla, S, Mellor, I R, Sansom, M S, Karle, I L, Flippen-Anderson, J L, Uma, K, Krishna, K, Sukumar, M, Balaram, P

“…Voltage dependent membrane channels are formed by the zervamicins, a group of alpha-aminoisobutyric acid containing peptides. The role of polar residues like…”
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Peptide Hybrids Containing α- and β-Amino Acids: Structure of a Decapeptide β-Hairpin with Two Facing β-Phenylalanine Residues by Karle, Isabella L., Gopi, Hosahudya N., Balaram, Padmanabhan

“…A β-hairpin conformation has been characterized in crystals of the decapeptide t-butoxycarbonyl-Leu-Val-βPhe-Val-DPro-Gly-Leu-βPhe-Val-Val-methyl ester [βPhe;…”
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Lithium Perhydroantamanide Complex (2:1): Exposure of the Peptide Backbone in the Analog of Antamanide with Antitoxic Impotency by Karle, Isabella L.

“…The synthetic analog of antamanide in which all four phenylalanyl residues are hydrogenated to cyclohexylalanyl (Cha) residues,…”
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Apolar peptide models for conformational heterogeneity, hydration, and packing of polypeptide helices: crystal structure of hepta- and octapeptides containing alpha-aminoisobutyric acid by Karle, I L, Flippen-Anderson, J L, Uma, K, Balaram, P

“…The crystal structures of two helical peptides Boc-Val-Ala-Leu-Aib-Val-ala-Leu-OMe (VALU-7) and Boc-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe (VALU-8) have been…”
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