Search Results - "Karl B. Seydel"

School-Age Children Are a Reservoir of Malaria Infection in Malawi by Walldorf, Jenny A, Cohee, Lauren M, Coalson, Jenna E, Bauleni, Andy, Nkanaunena, Kondwani, Kapito-Tembo, Atupele, Seydel, Karl B, Ali, Doreen, Mathanga, Don, Taylor, Terrie E, Valim, Clarissa, Laufer, Miriam K

“…Malaria surveillance and interventions in endemic countries often target young children at highest risk of malaria morbidity and mortality. We aimed to…”
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Cerebral malaria is associated with differential cytoadherence to brain endothelial cells by Storm, Janet, Jespersen, Jakob S, Seydel, Karl B, Szestak, Tadge, Mbewe, Maurice, Chisala, Ngawina V, Phula, Patricia, Wang, Christian W, Taylor, Terrie E, Moxon, Christopher A, Lavstsen, Thomas, Craig, Alister G

“…Sequestration of Plasmodium falciparum ‐infected erythrocytes (IE) within the brain microvasculature is a hallmark of cerebral malaria (CM). Using a…”
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Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children by Moxon, Christopher A., Wassmer, Samuel C., Milner, Danny A., Chisala, Ngawina V., Taylor, Terrie E., Seydel, Karl B., Molyneux, Malcolm E., Faragher, Brian, Esmon, Charles T., Downey, Colin, Toh, Cheng-Hock, Craig, Alister G., Heyderman, Robert S.

“…Cerebral malaria (CM) is a major cause of mortality in African children and the mechanisms underlying its development, namely how malaria-infected erythrocytes…”
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Aggressive antipyretics in central nervous system malaria: Study protocol of a randomized-controlled trial assessing antipyretic efficacy and parasite clearance effects (Malaria FEVER study) by Chilombe, Moses B, McDermott, Michael P, Seydel, Karl B, Mathews, Manoj, Mwenechanya, Musaku, Birbeck, Gretchen L

“…Malaria remains a major public health challenge in Africa where annually, ~250,000 children with malaria experience a neurologic injury with subsequent…”
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Protocol for a magnetic resonance imaging study of participants in the fever RCT: Does fever control prevent brain injury in malaria? by Chilombe, Moses B, Seydel, Karl B, Hammond, Colleen A, Mwanza, Suzanna, Patel, Archana A, Lungu, Frank, Wa Somwe, Somwe, Kampondeni, Sam, Potchen, Michael J, McDermott, Michael P, Birbeck, Gretchen L

“…Despite eradication efforts, ~135,000 African children sustained brain injuries as a result of central nervous system (CNS) malaria in 2021. Newer antimalarial…”
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The ability of Interleukin-10 to negate haemozoin-related pro-inflammatory effects has the potential to restore impaired macrophage function associated with malaria infection by Tembo, Dumizulu, Harawa, Visopo, Tran, Tam C, Afran, Louise, Molyneux, Malcolm E, Taylor, Terrie E, Seydel, Karl B, Nyirenda, Tonney, Russell, David G, Mandala, Wilson

“…Although pro-inflammatory cytokines are involved in the clearance of Plasmodium falciparum during the early stages of the infection, increased levels of these…”
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Cerebral malaria: insight into pathology from optical coherence tomography by Tu, Zhanhan, Gormley, Jack, Sheth, Viral, Seydel, Karl B., Taylor, Terrie, Beare, Nicholas, Barrera, Valentina, Proudlock, Frank A., Manda, Chatonda, Harding, Simon, Gottlob, Irene

“…We aimed to investigate structural retinal changes in malarial retinopathy (MR) using hand-held optical coherence tomography (HH-OCT) to assess its diagnostic…”
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Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study by Birbeck, Gretchen L, Dr, Molyneux, Malcolm E, Prof, Kaplan, Peter W, Prof, Seydel, Karl B, MD, Chimalizeni, Yamikani F, MRCP, Kawaza, Kondwani, MRCP, Taylor, Terrie E, Prof

“…Summary Background Cerebral malaria, a disorder characterised by coma, parasitaemia, and no other evident cause of coma, is challenging to diagnose…”
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Simulation models predict that school-age children are responsible for most human-to-mosquito Plasmodium falciparum transmission in southern Malawi by Coalson, Jenna E, Cohee, Lauren M, Buchwald, Andrea G, Nyambalo, Andrew, Kubale, John, Seydel, Karl B, Mathanga, Don, Taylor, Terrie E, Laufer, Miriam K, Wilson, Mark L

“…Malaria persists in some high-transmission areas despite extensive control efforts. Progress toward elimination may require effective targeting of specific…”
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Quantitative Assessment of Multiorgan Sequestration of Parasites in Fatal Pediatric Cerebral Malaria by Milner, Danny A., Lee, Jonathan J., Frantzreb, Charles, Whitten, Richard O., Kamiza, Steve, Carr, Richard A., Pradham, Alana, Factor, Rachel E., Playforth, Krupa, Liomba, George, Dzamalala, Charles, Seydel, Karl B., Molyneux, Malcolm E., Taylor, Terrie E.

“…Children in sub-Saharan Africa continue to acquire and die from cerebral malaria, despite efforts to control or eliminate the causative agent, Plasmodium…”
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Genotyping Plasmodium falciparum gametocytes using amplicon deep sequencing by Vareta, Jimmy, Horstman, Natalie A, Adams, Matthew, Seydel, Karl B, McCann, Robert S, Cohee, Lauren M, Laufer, Miriam K, Takala-Harrison, Shannon

“…Understanding the dynamics of gametocyte production in polyclonal Plasmodium falciparum infections requires a genotyping method that detects distinct…”
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Retinal imaging technologies in cerebral malaria: a systematic review by Wilson, Kyle J, Dhalla, Amit, Meng, Yanda, Tu, Zhanhan, Zheng, Yalin, Mhango, Priscilla, Seydel, Karl B, Beare, Nicholas A V

“…Cerebral malaria (CM) continues to present a major health challenge, particularly in sub-Saharan Africa. CM is associated with a characteristic malarial…”
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Comparison of CD8 + T Cell Accumulation in the Brain During Human and Murine Cerebral Malaria by Barrera, Valentina, Haley, Michael J, Strangward, Patrick, Attree, Elizabeth, Kamiza, Steve, Seydel, Karl B, Taylor, Terrie E, Milner, Jr, Danny A, Craig, Alister G, Couper, Kevin N

“…CD8 T cells have been shown to play a critical role in the pathogenesis of experimental cerebral malaria (ECM) in mice, but their role in development of human…”
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Risk factors for acute kidney injury at presentation among children with CNS malaria: a case control study by Tembo, Derby, Mwanza, Suzanna, Mwaba, Chisambo, Dallah, Ifunanya, Wa Somwe, Somwe, Seydel, Karl B, Birbeck, Gretchen L

“…Recent research has established that acute kidney injury (AKI) is a common problem in severe paediatric malaria. Limited access to kidney diagnostic studies in…”
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Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1 by Bernabeu, Maria, Gunnarsson, Celina, Vishnyakova, Maria, Howard, Caitlin C, Nagao, Ryan J, Avril, Marion, Taylor, Terrie E, Seydel, Karl B, Zheng, Ying, Smith, Joseph D

“…Cerebral malaria is a severe neurological complication associated with sequestration of -infected erythrocytes (IE) in the brain microvasculature, but the…”
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Correction: The ability of Interleukin-10 to negate haemozoin-related pro-inflammatory effects has the potential to restore impaired macrophage function associated with malaria infection by Tembo, Dumizulu, Harawa, Visopo, Tran, Tam C, Afran, Louise, Molyneux, Malcolm E, Taylor, Terrie E, Seydel, Karl B, Nyirenda, Tonney, Russell, David G, Mandala, Wilson

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Post hospital admission blood lactate measurements are associated with mortality but not neurologic morbidity in children with cerebral malaria by Olowojesiku, Ronke, Sherman, Meredith G, Mukadam, Amina M, Imam, Rami, Chastang, Kennedy M, Seydel, Karl B, Liomba, Alice M, Barber, John R, O'Brien, Nicole F, Postels, Douglas G

“…In children with cerebral malaria (CM) admission blood lactate has previously guided intravenous fluid therapy and been validated as a prognostic biomarker…”
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School-based screening and treatment may reduce P. falciparum transmission by Cohee, Lauren M., Valim, Clarissa, Coalson, Jenna E., Nyambalo, Andrew, Chilombe, Moses, Ngwira, Andrew, Bauleni, Andy, Seydel, Karl B., Wilson, Mark L., Taylor, Terrie E., Mathanga, Don P., Laufer, Miriam K.

“…In areas where malaria remains entrenched, novel transmission-reducing interventions are essential for malaria elimination. We report the impact…”
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Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study by Conroy, Andrea L, Phiri, Happy, Hawkes, Michael, Glover, Simon, Mallewa, Mac, Seydel, Karl B, Taylor, Terrie E, Molyneux, Malcolm E, Kain, Kevin C

“…Differentiating cerebral malaria (CM) from other causes of serious illness in African children is problematic, owing to the non-specific nature of the clinical…”
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A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children by Walker, Isobel S, Dini, Saber, Aitken, Elizabeth H, Damelang, Timon, Hasang, Wina, Alemu, Agersew, Jensen, Anja T R, Rambhatla, Janavi S, Opi, D Herbert, Duffy, Michael F, Takashima, Eizo, Harawa, Visopo, Tsuboi, Takafumi, Simpson, Julie A, Mandala, Wilson, Taylor, Terrie E, Seydel, Karl B, Chung, Amy W, Rogerson, Stephen J

“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration…”
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