Search Results - "Karki, Shakun"

Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease by Mazzotta, Celestina, Basu, Sanchita, Gower, Adam C., Karki, Shakun, Farb, Melissa G., Sroczynski, Emily, Zizza, Elaina, Sarhan, Anas, Pande, Ashvin N., Walsh, Kenneth, Dobrilovic, Nikola, Gokce, Noyan

“…There is growing recognition that adipose tissue-derived proatherogenic mediators contribute to obesity-related cardiovascular disease. We sought to…”
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SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL by Chakrabarti, Partha, English, Taylor, Karki, Shakun, Qiang, Li, Tao, Rong, Kim, Juyoun, Luo, Zhijun, Farmer, Stephen R., Kandror, Konstantin V.

“…Recent studies have established SIRT1 as an important regulator of lipid metabolism, although the mechanism of its action at the molecular level has not been…”
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Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity by Ngo, Doan T M, Farb, Melissa G, Kikuchi, Ryosuke, Karki, Shakun, Tiwari, Stephanie, Bigornia, Sherman J, Bates, David O, LaValley, Michael P, Hamburg, Naomi M, Vita, Joseph A, Hess, Donald T, Walsh, Kenneth, Gokce, Noyan

“…Experimental studies suggest that visceral adiposity and adipose tissue dysfunction play a central role in obesity-related cardiometabolic complications…”
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Insulin Status and Vascular Responses to Weight Loss in Obesity by Bigornia, Sherman J., PhD, Farb, Melissa G., PhD, Tiwari, Stephanie, BS, Karki, Shakun, PhD, Hamburg, Naomi M., MD, Vita, Joseph A., MD, Hess, Donald T., MD, LaValley, Michael P., PhD, Apovian, Caroline M., MD, Gokce, Noyan, MD

“…Objectives The aim of this study was to determine whether the effects of weight loss on arterial function are differentially modified by insulin status…”
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The multi-level action of fatty acids on adiponectin production by fat cells by Karki, Shakun, Chakrabarti, Partha, Huang, Guanrong, Wang, Hong, Farmer, Stephen R, Kandror, Konstantin V

“…Current epidemics of diabetes mellitus is largely caused by wide spread obesity. The best-established connection between obesity and insulin resistance is the…”
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Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity by Karki, Shakun, Farb, Melissa G, Sharma, Vishva M, Jash, Sukanta, Zizza, Elaina J, Hess, Donald T, Carmine, Brian, Carter, Cullen O, Pernar, Luise I, Apovian, Caroline M, Puri, Vishwajeet, Gokce, Noyan

“…Background Pathophysiological mechanisms that connect obesity to cardiovascular disease are incompletely understood. FSP27 (Fat-specific protein 27) is a lipid…”
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Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans by Hess, Donald T., Apovian, Caroline, Myers, Samantha, Farb, Melissa G., Karki, Shakun, Gokce, Noyan

“…Background. Dysregulated lipolysis has been implicated in mechanisms of cardiometabolic disease and inflammation in obesity. Purpose. We sought to examine the…”
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Longitudinal changes in zinc transport kinetics, metallothionein and zinc transporter expression in a blood–brain barrier model in response to a moderately excessive zinc environment by Bobilya, Dennis J., Gauthier, Nicole A., Karki, Shakun, Olley, Bryony J., Thomas, W. Kelly

“…A blood–brain barrier (BBB) model composed of porcine brain capillary endothelial cells (BCEC) was exposed to a moderately excessive zinc environment (50…”
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FSP27 and Links to Obesity and Diabetes Mellitus by Karki, Shakun

“…Purpose of Review Obesity is a pandemic, yet preventable healthcare problem. Insulin resistance, diabetes mellitus, dyslipidemia, and cardiovascular…”
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Abstract 14820: Pericardial Adipose Tissue Thrombospondin-1 Associates With Anti-Angiogenesis in Ischemic Heart Disease by Ahmed, Bulbul, Farb, Melissa G, Sroczynski, Emily, Karki, Shakun, Edwards, Niloo, Gokce, Noyan

“…Defective angiogenesis contributes to mechanisms of ischemic heart disease. Accumulation of ectopic pericardial adipose tissue has been associated with…”
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Pericardial Adipose Tissue Thrombospondin-1 Associates With Antiangiogenesis in Ischemic Heart Disease by Ahmed, Bulbul, Farb, Melissa G, Karki, Shakun, D'Alessandro, Sophia, Edwards, Niloo M, Gokce, Noyan

“…Accumulation of ectopic pericardial adipose tissue has been associated with cardiovascular complications which, in part, may relate to adipose-derived factors…”
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Abstract P3003: Endothelial-Specific Expression Of Cidec Improves High-Fat Diet-induced Vascular And Metabolic Dysfunction by Balakrishnan, Bijinu, Gupta, Abhishek, Sharma, Vishva M, Slayton, Mark, Gentner, Kailey, Karki, Shakun, Muturi, Harrison, Najjar, Sonia M, Loria, Analia S, Gokce, Noyan, Puri, Vishwajeet

“…Cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC), originally identified to be a lipid-droplet associated protein in adipocytes,…”
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Abstract 146: Endothelial-Specific Expression Of CIDEC Improves High-Fat Diet-Induced Vascular And Metabolic Dysfunction by Balakrishnan, Bijinu, Gupta, Abhishek, Sharma, Vishva, Slayton, Mark, Gentner, Kailey, Karki, Shakun, Muturi, Harrison, Najjar, Sonia M, Loria, Analia, GOKCE, Noyan, Puri, Vishwajeet

“…Cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC), originally identified to be a lipid-droplet associated protein in adipocytes,…”
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Human CIDEC transgene improves lipid metabolism and protects against high fat diet–induced glucose intolerance in mice by Gupta, Abhishek, Balakrishnan, Bijinu, Karki, Shakun, Slayton, Mark, Jash, Sukanta, Banerjee, Sayani, Grahn, Tan Hooi Min, Jambunathan, Srikarthika, Disney, Sarah, Hussein, Hebaallaha, Kong, Dong, Lowell, Bradford B., Natarajan, Purushothaman, Reddy, Umesh K., Gokce, Noyan, Sharma, Vishva M., Puri, Vishwajeet

“…Cell death–inducing DNA fragmentation factor-like effector C (CIDEC) expression in adipose tissue positively correlates with insulin sensitivity in obese…”
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Endothelial-Specific Expression of CIDEC Improves High-Fat Diet-Induced Vascular and Metabolic Dysfunction by Balakrishnan, Bijinu, Gupta, Abhishek, Basri, Rabia, Sharma, Vishva M, Slayton, Mark, Gentner, Kailey, Becker, Chloe C, Karki, Shakun, Muturi, Harrison, Najjar, Sonia M, Loria, Analia S, Gokce, Noyan, Puri, Vishwajeet

“…Cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC), originally identified to be a lipid droplet-associated protein in adipocytes,…”
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Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease by Mazzotta, Celestina, Basu, Sanchita, Gower, Adam C., Karki, Shakun, Farb, Melissa G., Sroczynski, Emily, Zizza, Elaina, Sarhan, Anas, Pande, Ashvin N., Walsh, Kenneth, Dobrilovic, Nikola, Gokce, Noyan

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Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity by Ngo, Doan T M, Sverdlov, Aaron L, Karki, Shakun, Macartney-Coxson, Donia, Stubbs, Richard S, Farb, Melissa G, Carmine, Brian, Hess, Donald T, Colucci, Wilson S, Gokce, Noyan

“…Obesity, particularly visceral adiposity, has been linked to mitochondrial dysfunction and increased oxidative stress, which have been suggested as mechanisms…”
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COMBINED EXERCISE TRAINING REDUCES BLOOD PRESSURE, ARTERIAL STIFFNESS, AND INSULIN RESISTANCE IN OBESE PREHYPERTENSIVE ADOLESCENT GIRLS by Karki, Shakun, Son, Won‐Mok, Seo, Kook‐Eun, Park, Song Young

“…Abstract only Childhood obesity is strongly linked to pathological processes for cardiovascular diseases in adults. Obese adolescent girls with high blood…”
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Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation by Zuriaga, María A., Fuster, José J., Farb, Melissa G., MacLauchlan, Susan, Bretón-Romero, Rosa, Karki, Shakun, Hess, Donald T., Apovian, Caroline M., Hamburg, Naomi M., Gokce, Noyan, Walsh, Kenneth

“…The accumulation of visceral adiposity is strongly associated with systemic inflammation and increased cardiometabolic risk. WNT5A, a non-canonical WNT ligand,…”
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LBSUN87 Human Cidec Transgene Improves Lipid Metabolism And Protects Against High Fat-diet Induced Glucose Intolerance In Mice by Gupta, Abhishek, Balakrishnan, Bijinu, Karki, Shakun, Slayton, Mark, Gokce, Noyan, Sharma, Vishva M, Puri, Vishwajeet

“…Abstract CIDEC expression in adipose tissue positively correlates with insulin sensitivity in obese humans. Further, a single-nucleotide CIDEC variant (E186X)…”
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