Search Results - "Karisola, P."

Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells by Palomäki, J, Karisola, P, Pylkkänen, L, Savolainen, K, Alenius, H

“…Abstract Nanomaterials improve everyday products but their safety for human health is poorly known. In this study we explored immunological effects of five…”
Get full text

Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis by Vähävihu, K., Ala-Houhala, M., Peric, M., Karisola, P., Kautiainen, H., Hasan, T., Snellman, E., Alenius, H., Schauber, J., Reunala, T.

“…Summary Background  Narrowband ultraviolet B (NB‐UVB) is a routine treatment for psoriasis and atopic dermatitis (AD) but its effect on vitamin D balance is…”
Get full text

Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model by Ottman, Noora, Ruokolainen, Lasse, Suomalainen, Alina, Sinkko, Hanna, Karisola, Piia, Lehtimäki, Jenni, Lehto, Maili, Hanski, Ilkka, Alenius, Harri, Fyhrquist, Nanna

“…Sufficient exposure to natural environments, in particular soil and its microbes, has been suggested to be protective against allergies. We aim at gaining more…”
Get full text

N-terminal hevein-like domains (4.3 kDa) but not 31 kDa endochitinases are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit syndrome by Karisola, P., Kotovuori, A., Poikonen, S., Niskanen, E., Kalkkinen, N., Turjanmaa, K., Palosuo, T., Reunala, T., Alenius, H., Kulomaa, M.

“…IgE-mediated clinical reactions in latex-fruit syndrome seem to be evoked by 4.3 kDa HLD molecules alone but not when linked to 31 kDa endochitinases. [...]a…”
Get full text

Environmental biodiversity, human microbiota, and allergy are interrelated by Hanski, Ilkka, von Hertzen, Leena, Fyhrquist, Nanna, Koskinen, Kaisa, Torppa, Kaisa, Laatikainen, Tiina, Karisola, Piia, Auvinen, Petri, Paulin, Lars, Mäkelä, Mika J, Vartiainen, Erkki, Kosunen, Timo U, Alenius, Harri, Haahtela, Tari

“…Rapidly declining biodiversity may be a contributing factor to another global megatrend—the rapidly increasing prevalence of allergies and other chronic…”
Get full text

How does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s) by McCrory, Cathal, Fiorito, Giovanni, Ni Cheallaigh, Cliona, Polidoro, Silvia, Karisola, Piia, Alenius, Harri, Layte, Richard, Seeman, Teresa, Vineis, Paolo, Kenny, Rose Anne

“…•Low socio-economic position (SEP) is linked with earlier morbidity and mortality.•Researchers have debated how the social environment gets biologically…”
Get full text

Endotyping asthma related to 3 different work exposures by Suojalehto, Hille, Ndika, Joseph, Lindström, Irmeli, Airaksinen, Liisa, Karisola, Piia, Alenius, Harri

“…Work exposures play a significant role in adult-onset asthma, but the mechanisms of work-related asthma are not fully elucidated. We aimed to reveal the…”
Get full text

Hevein-like domain IV in wheat germ agglutinin (WGA) is responsible for the majority of IgE cross-reactivity between WGA and hevein (Hev b 6.02) by Karisola, P., Alenius, H., Turjanmaa, K., Reunala, T., Kalkkinen, N., Palosuo, T., Kulomaa, M.

Get full text

Epigenetic Clocks and Allostatic Load Reveal Potential Sex-Specific Drivers of Biological Aging by McCrory, Cathal, Fiorito, Giovanni, McLoughlin, Sinead, Polidoro, Silvia, Cheallaigh, Cliona Ni, Bourke, Nollaig, Karisola, Piia, Alenius, Harri, Vineis, Paolo, Layte, Richard, Kenny, Rose Anne

“…Abstract Allostatic load (AL) and epigenetic clocks both attempt to characterize the accelerated aging of biological systems, but at present it is unclear…”
Get full text

Bet v 1 triggers antiviral‐type immune signalling in birch‐pollen‐allergic individuals by Wisgrill, Lukas, Fyhrquist, Nanna, Ndika, Joseph, Paalanen, Laura, Berger, Angelika, Laatikainen, Tiina, Karisola, Piia, Haahtela, Tari, Alenius, Harri

“…Background In allergic patients, clinical symptoms caused by pollen remind of symptoms triggered by viral respiratory infections, which are also the main cause…”
Get full text

Narrow-band UVB radiation triggers diverse changes in the gene expression and induces the accumulation of M1 macrophages in human skin by Karisola, Piia, Nikkola, Veera, Joronen, Heli, Ylianttila, Lasse, Grönroos, Mari, Partonen, Timo, Snellman, Erna, Alenius, Harri

“…The underlying molecular mechanisms that determine the biological effects of UVB radiation exposure on human skin are still only partially comprehended. Our…”
Get full text

Systemic gene signature of inhaled corticosteroid treatment in allergic asthma to flour by Ndika, Joseph, Suojalehto, Hille, Lindström, Irmeli, Airaksinen, Liisa, Wisgrill, Lukas, Alenius, Harri, Karisola, Piia

Get full text

Inhalation and Oropharyngeal Aspiration Exposure to Rod-Like Carbon Nanotubes Induce Similar Airway Inflammation and Biological Responses in Mouse Lungs by Kinaret, Pia, Ilves, Marit, Fortino, Vittorio, Rydman, Elina, Karisola, Piia, Lähde, Anna, Koivisto, Joonas, Jokiniemi, Jorma, Wolff, Henrik, Savolainen, Kai, Greco, Dario, Alenius, Harri

“…Carbon nanotubes (CNTs) have the potential to impact technological and industrial progress, but their production and use may, in some cases, cause serious…”
Get full text

Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model by Kooter, Ingeborg, Ilves, Marit, Gröllers-Mulderij, Mariska, Duistermaat, Evert, Tromp, Peter C, Kuper, Frieke, Kinaret, Pia, Savolainen, Kai, Greco, Dario, Karisola, Piia, Ndika, Joseph, Alenius, Harri

“…More than 5% of any population suffers from asthma, and there are indications that these individuals are more sensitive to nanoparticle aerosols than the…”
Get full text

Effects of Superficial Scratching and Engineered Nanomaterials on Skin Gene Profiles and Microbiota in SKH-1 Mice by Mäenpää, Kuunsäde, Ilves, Marit, Zhao, Lan, Alenius, Harri, Sinkko, Hanna, Karisola, Piia

“…Scratching damages upper layers of the skin, breaks this first line of immune defence, and leads to inflammation response, which often also modifies the…”
Get full text

Oral exposure to Ag or TiO2 nanoparticles perturbed gut transcriptome and microbiota in a mouse model of ulcerative colitis by Wang, Shuyuan, Kang, Xing, Alenius, Harri, Wong, Sunny Hei, Karisola, Piia, El-Nezami, Hani

“…Silver (nAg) and titanium dioxide (nTiO2) nanoparticles improve texture, flavour or anti-microbial properties of various food products and packaging materials…”
Get full text

Skin microbiota of oxazolone-induced contact hypersensitivity mouse model by Mäenpää, Kuunsäde, Wang, Shuyuan, Ilves, Marit, El-Nezami, Hani, Alenius, Harri, Sinkko, Hanna, Karisola, Piia

“…Contact allergy is a common skin allergy, which can be studied utilising contact hypersensitivity (CHS) animal model. However, it is not clear, whether CHS is…”
Get full text

A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy: Efficacy and Humoral Immune Responses in 50 Children by Palosuo, Kati, Karisola, Piia, Savinko, Terhi, Fyhrquist, Nanna, Alenius, Harri, Mäkelä, Mika J.

“…Egg allergy is the second most common food allergy in children. Persistent food allergy increases the risk of anaphylaxis and reduces the quality of life. To…”
Get full text

Mechanistic Similarities between 3D Human Bronchial Epithelium and Mice Lung, Exposed to Copper Oxide Nanoparticles, Support Non‐Animal Methods for Hazard Assessment by Ndika, Joseph, Ilves, Marit, Kooter, Ingeborg M., Gröllers‐Mulderij, Mariska, Duistermaat, Evert, Tromp, Peter C., Kuper, Frieke, Kinaret, Pia, Greco, Dario, Karisola, Piia, Alenius, Harri

“…The diversity and increasing prevalence of products derived from engineered nanomaterials (ENM), warrants implementation of non‐animal approaches to health…”
Get full text

Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis by Ndika, Joseph, Airaksinen, Liisa, Suojalehto, Hille, Karisola, Piia, Fyhrquist, Nanna, Puustinen, Anne, Alenius, Harri

“…Seasonal allergic rhinitis (SAR) caused by intermittent exposure to seasonal pollen causes itching, nasal congestion, and repeated sneezing, with profound…”
Get full text