Spontaneous bilateral avascular necrosis of knees and hip leading to early bilateral total hip arthroplasty: a case report of an 18-year-old man recently diagnosed with Crohn’s disease

Avascular necrosis (AVN) is linked to considerable morbidity, resulting in severe pain and functional impairment. Herein, for the first time, we reported an 18-year-old patient with Crohn’s disease during the remission phase under Azathioprine therapy who presented with articular pain. Although no u...

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Bibliographic Details
Published in:	Clinical journal of gastroenterology Vol. 17; no. 4; pp. 663 - 670
Main Authors:	Khanmirzaei, Amir, Jazi, Kimia, Azarinoush, Gelareh, Shirmohammadi, Maryam, Karimtabar, Hajar, Pezeshgi Modarres, Mehdi, Masoumi, Maryam
Format:	Journal Article
Language:	English
Published:	Singapore Springer Nature Singapore 01-08-2024
Subjects:	Abdominal Surgery Adolescent Arthroplasty, Replacement, Hip - adverse effects Case Report Colorectal Surgery Crohn Disease - complications Femur Head Necrosis - diagnostic imaging Femur Head Necrosis - etiology Gastroenterology Hepatology Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Knee Joint - diagnostic imaging Male Medicine Medicine & Public Health Surgical Oncology Avascular necrosis Inflammatory bowel disease Osteonecrosis Lower back pain Crohn’s disease
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Summary:	Avascular necrosis (AVN) is linked to considerable morbidity, resulting in severe pain and functional impairment. Herein, for the first time, we reported an 18-year-old patient with Crohn’s disease during the remission phase under Azathioprine therapy who presented with articular pain. Although no underlying risk factors, the patient was diagnosed with severe AVN of the bilateral femoral head and both knees simultaneously following pain in involved areas. This case highlights the importance of demand multidisciplinary approach to chronic disease. Moreover, clinicians should be aware of articular manifestations in IBD patients to diagnose and treat these conditions as soon as possible. Patients should be evaluated for their psychologic, gastrointestinal, and extra-gastrointestinal comorbidities during each follow-up visit.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1865-7257 1865-7265 1865-7265
DOI:	10.1007/s12328-024-01987-y