Search Results - "Karimian, Khashayar"

N-PEGylated Thiazolium Salt: A Green and Reusable Homogenous Organocatalyst for the Synthesis of Benzoins and Acyloins by Haghighi, Ali Javaheri, Mokhtari, Javad, Karimian, Khashayar

“…N -PEGylated-thiazolium salt is used as efficient catalyst for the benzoin condensation. The catalyst was synthesized by reaction of activated polyethylene…”
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A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy by Karimi, Maryam, Karimian, Khashayar, Heli, Hossein

“…A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the…”
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Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines by Ajdari, Mohammadreza, Ranjbar, Aliyeh, Karimian, Khashayar, Karimi, Maryam, Heli, Hossein, Sattarahmady, Naghmeh

“…Docetaxel (DXL) is an antineoplastic agent for cancer treatment, the therapeutic efficiency of which is limited due to low solubility, hydrophobicity, and…”
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On the Mechanism of Formation and the Synthesis of Pantoprazole Sodium Sesquihydrate-Related Compound E: A Phantom Chemical Entity by Yari, Ahmad, Zolali, Amin, Karimian, Khashayar

“…A mechanism for the formation of pantoprazole related compound E (RC E) is proposed involving the formation of a radical cation in the pH range of 5–8. pH…”
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Resolution of Racemic Mixtures by Phase Transition of PEGylated Resolving Agents by Mokhtari, Javad, Azarnoosh, Sahar, Karimian, Khashayar

“…A novel, efficient, and simple method for the resolution of racemic mixtures is presented in which PEGylated resolving agents are subjected to diastereomeric…”
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Novel Method for the Isolation of Proteins and Small Target Molecules from Biological and Aqueous Media by Salt-Assisted Phase Transformation of Their PEGylated Recognition Counterparts by Mokhtari, Javad, Nourisefat, Maryam, Zamiri, Bita, Fotouhi, Leila, Zarnani, Amir-Hassan, Moosavi-Movahedi, Ali Akbar, Karimian, Khashayar

“…An efficient and simple method for the application of PEGylated affinity ligands in precipitative isolation of protein target molecules (TMs) from a biological…”
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Iron chelator research: past, present, and future by Tam, Tim F, Leung-Toung, Regis, Li, Wanren, Wang, Yingsheng, Karimian, Khashayar, Spino, Michael

“…The occurrence of in vivo iron toxicity in the human body can be categorized into iron overload and non-iron overload conditions. Iron overload conditions are…”
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Thiol proteases: inhibitors and potential therapeutic targets by Leung-Toung, Regis, Zhao, Yanqing, Li, Wanren, Tam, Tim F, Karimian, Khashayar, Spino, Michael

“…A better understanding of the biological roles and the pathological consequences of thiol-dependent enzymes has emerged in recent years, and hence considerable…”
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Medicinal chemistry and properties of 1,2,4-thiadiazoles by Tam, Tim Fat, Leung-Toung, Regis, Li, Wanren, Spino, Michael, Karimian, Khashayar

“…1,2,4-Thiadiazole is a distinctive class of small heterocyclic thiol trapping agents that serve as an interesting pharmacophore in the design of inhibitors…”
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N-PEGylated (L)-Prolinamide: A Homogeneous, Solvent-Free, and Recyclable Catalyst for Scalable Enantioselective Aldol Reaction by Hosseini-Dastjerdi, Faezeh, Zandieh, Haniyeh, Yari, Ahmad, Mokhtari, Javad, Karimian, Khashayar

“…The unique physicochemical properties of PEG-400 were imparted to ( L )-prolinamide to afford a homogeneous, solvent-free, recyclable organocatalyst for…”
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Advances in iron chelation: an update by Heli, Hossein, Mirtorabi, Siamak, Karimian, Khashayar

“…Oxidative stress (caused by excess iron) can result in tissue damage, organ failure and finally death, unless treated by iron chelators. The causative factor…”
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Thiol-dependent enzymes and their inhibitors: a review by Leung-Toung, Regis, Li, Wanren, Tam, Tim F, Karimian, Khashayar

“…Biological thiol-dependent enzymes have recently received extensive attention in the literature because of their involvement in a variety of physiopathological…”
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Chiral intermediates in thiamin catalysis. Stereochemical course of the decarboxylation step in the conversion of pyruvate to acetaldehyde by Kluger, Ronald, Karimian, Khashayar, Kitamura, Kelly

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1,2,4-Thiadiazole: A novel Cathepsin B inhibitor by Leung-Toung, Regis, Wodzinska, Jolanta, Li, Wanren, Lowrie, Jayme, Kukreja, Rahul, Desilets, Denis, Karimian, Khashayar, Tam, Tim Fat

“…A novel class of Cathepsin B inhibitors has been developed with a 1,2,4-thiadiazole heterocycle as the thiol trapping pharmacophore. Several compounds with…”
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Synthesis of 3-Substituted Bicyclic Imidazo[1,2-d][1,2,4]thiadiazoles and Tricyclic Benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazoles by Leung-Toung, Regis, Tam, Tim F, Zhao, Yanqing, Simpson, Craig D, Li, Wanren, Desilets, Denis, Karimian, Khashayar

“…A versatile synthetic route to potentially useful fused-ring [1,2,4]thiadiazole scaffolds (e.g., 7a and 10b) via exchange reactions of the precursor…”
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Synthesis, characterization, and properties of hexadecyl silica: a novel hydrophobic matrix for protein immobilization by Nemat-Gorgani, Mohsen, Karimian, Khashayar, Mohanazadeh, Farajolah

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Application of polymer-bound thiazolium salts to the synthesis of acyloins and benzoins: Effects of solvent and substituents of the thiazolium nucleus by Karimian, Khashayar, Mohanazadeh, Farajolah, Rezai, Shaheen

“…Covalent immobilization of the thiazole nucleus on a chloromethylated polystyrene copolymer results in the formation of a catalytically active thiazolium salt,…”
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3-Substituted Imidazo[1,2-d][1,2,4]-thiadiazoles:  A Novel Class of Factor XIIIa Inhibitors by Leung-Toung, Regis, Tam, Tim F, Wodzinska, Jolanta M, Zhao, Yanqing, Lowrie, Jayme, Simpson, Craig D, Karimian, Khashayar, Spino, Michael

“…A new class of selective FXIIIa inhibitors with a bicyclic [1,2,4]-thiadiazole pharmacophore is described. At 160 μM, compound 8 caused 50% reduction in fibrin…”
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Application of a Polymer-Bound Thiazolium Salt to the Synthesis of Alpha-Hydroxy Ketones with an Aromatic and Aliphatic Substituent (Bencyloins) [1] by Khashayar Karimian, Farajollah Mohanazadeh

“…Alpha-Hydroxy ketones with an aromatic and aliphatic substituent were prepared with condensation of aromatic and aliphatic aldehydes in the presence of…”
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ON THE SYNTHESIS AND CHEMISTRY OF 2-(1-HYDROXY-3,7-DIMETHYL-1-OCT-6-ENYL)THIAMINE CHLORIDE HYDROCHLORIDE: A BIOCHEMICAL PRECURSOR TO 1,10-DIISOPENTENYL-3,4-DIHYDROARTEMISIA KETONE by KARIMIAN, KHASHAYAR

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