Salivary Adiponectin and Albumin Levels on the Gingival Conditions of Patients Undergoing Bariatric Surgery: A Cohort Study

This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 kg/m ) who underwent bariatric surgery Roux-en-Y gastric by...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of environmental research and public health Vol. 20; no. 7; p. 5261
Main Authors:	Sales-Peres, Silvia Helena de Carvalho, Houghton, Jack, Meira, Gabriela de Figueiredo, Moura-Grec, Patrícia Garcia de, Brienze, Sergio Luis Aparecido, Karim, Belkais Abuuasha, Carpenter, Guy Howard
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 24-03-2023 MDPI
Subjects:	Adipocytes Adiponectin Albumin Albumins Bariatric Surgery Biomarkers Body mass Body mass index Body size Body weight loss Cardiovascular disease Chronic illnesses Cohort analysis Cohort Studies Coronary vessels Diabetes Electrophoresis Enzyme-linked immunosorbent assay Gastric bypass Gastrointestinal surgery Gingival Diseases Gum disease Health services Humans Immunoblotting Inflammation Inflammatory diseases Insulin resistance Medical records Medical screening Neutrophil collagenase Obesity Obesity, Morbid - surgery Patients Periodontal disease Periodontal diseases Periodontitis Proteomics Saliva Statistical analysis Surgery Type 2 diabetes Vein & artery diseases Weight control Weight Loss Western blotting Womens health Brazil United Kingdom United States > US adiponectin salivary biomarkers obesity periodontal disease albumin
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 kg/m ) who underwent bariatric surgery Roux-en-Y gastric bypass (RYGB) in System Health Public in Brazil. Data on demographic and anthropometric measures were extracted from medical records preoperatively and 6 and 12 months post-surgery. The variables assessed were: probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and stimulated whole-mouth saliva. In this study, saliva samples were analyzed by electrophoresis and immunoblotting. The ELISA kit was used to measure the MMP8 levels to determine potential markers for obesity. Adiponectin and albumin levels were also evaluated. Weight loss was associated with significant changes in patients' periodontal clinical data. Although 7 out of 10 periodontal patients showed an increase in salivary adiponectin levels after root planning treatment, when analyzed by Western blotting, the increase was not statistically significant (21.1 ± 4.8 to 26.3 ± 9.4 arbitrary units, > 0.99). There was no correlation between albumin levels and salivary adiponectin pre-surgery, nor 6 months or 12 months after surgery. Weight loss was not improved by low-grade inflammation in bariatric patients, since albumin levels were similar between periods. Periodontitis is an inflammatory disease that is modulated by several factors, among which adiponectin plays an important role for the treatment of periodontal disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1660-4601 1661-7827 1660-4601
DOI:	10.3390/ijerph20075261