Search Results - "Karikó, Katalin"

Developing mRNA for Therapy by Karikó, Katalin

“…Messenger RNA was discovered in 1961 and it took 60 years until the first mRNA became FDA-approved product in the form of COVID-19 mRNA vaccine. During those…”
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Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema by Szőke, Dániel, Kovács, Gábor, Kemecsei, Éva, Bálint, László, Szoták-Ajtay, Kitti, Aradi, Petra, Styevkóné Dinnyés, Andrea, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Karikó, Katalin, Kataru, Raghu P., Hope, Michael J., Weissman, Drew, Mehrara, Babak J., Pardi, Norbert, Jakus, Zoltán

“…Lack or dysfunction of the lymphatics leads to secondary lymphedema formation that seriously reduces the function of the affected organs and results in…”
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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination by Pardi, Norbert, Hogan, Michael J., Pelc, Rebecca S., Muramatsu, Hiromi, Andersen, Hanne, DeMaso, Christina R., Dowd, Kimberly A., Sutherland, Laura L., Scearce, Richard M., Parks, Robert, Wagner, Wendeline, Granados, Alex, Greenhouse, Jack, Walker, Michelle, Willis, Elinor, Yu, Jae-Sung, McGee, Charles E., Sempowski, Gregory D., Mui, Barbara L., Tam, Ying K., Huang, Yan-Jang, Vanlandingham, Dana, Holmes, Veronica M., Balachandran, Harikrishnan, Sahu, Sujata, Lifton, Michelle, Higgs, Stephen, Hensley, Scott E., Madden, Thomas D., Hope, Michael J., Karikó, Katalin, Santra, Sampa, Graham, Barney S., Lewis, Mark G., Pierson, Theodore C., Haynes, Barton F., Weissman, Drew

“…A single, low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside-modified mRNA encoding the pre-membrane and envelope glycoproteins…”
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Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques by Pardi, Norbert, LaBranche, Celia C., Ferrari, Guido, Cain, Derek W., Tombácz, István, Parks, Robert J., Muramatsu, Hiromi, Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Polacino, Patricia, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Haynes, Barton F., Montefiori, David C., Hu, Shiu-Lok, Weissman, Drew

“…Despite the enormous effort in the development of effective vaccines against HIV-1, no vaccine candidate has elicited broadly neutralizing antibodies in…”
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Inhibition of Toll-like Receptor and Cytokine Signaling-A Unifying Theme in Ischemic Tolerance by Karikó, Katalin, Weissman, Drew, Welsh, Frank A.

“…Cerebral ischemia triggers acute inflammation, which exacerbates primary brain damage. Activation of the innate immune system is an important component of this…”
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In vitro-Transcribed mRNA Therapeutics: Out of the Shadows and Into the Spotlight by Karikó, Katalin

“…Warren and Lin2 review this field and give an exquisite account of the development of IVT mRNA encoding key transcription factors for production of human stem…”
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Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors by Foster, Jessica B, Griffin, Crystal, Rokita, Jo Lynne, Stern, Allison, Brimley, Cameron, Rathi, Komal, Lane, Maria V, Buongervino, Samantha N, Smith, Tiffany, Madsen, Peter J, Martinez, Daniel, Delaidelli, Alberto, Sorensen, Poul H, Wechsler-Reya, Robert J, Karikó, Katalin, Storm, Phillip B, Barrett, David M, Resnick, Adam C, Maris, John M, Bosse, Kristopher R

“…BackgroundPediatric brain tumors are the leading cause of cancer death in children with an urgent need for innovative therapies. Glypican 2 (GPC2) is a cell…”
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mRNA-based therapeutics — developing a new class of drugs by Sahin, Ugur, Karikó, Katalin, Türeci, Özlem

“…Key Points Messenger RNA (mRNA) is a pivotal molecule of life, involved in almost all aspects of cell biology. As the subject of basic and applied research for…”
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Modified uridines are the key to a successful message by Karikó, Katalin

“…Katalin Karikó describes the discovery that replacing uridine with pseudouridine renders RNA non-immunogenic. This paved the way for developing mRNA for…”
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Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models by Hotz, Christian, Wagenaar, Timothy R, Gieseke, Friederike, Bangari, Dinesh S, Callahan, Michelle, Cao, Hui, Diekmann, Jan, Diken, Mustafa, Grunwitz, Christian, Hebert, Andy, Hsu, Karl, Bernardo, Marie, Karikó, Katalin, Kreiter, Sebastian, Kuhn, Andreas N, Levit, Mikhail, Malkova, Natalia, Masciari, Serena, Pollard, Jack, Qu, Hui, Ryan, Sue, Selmi, Abderaouf, Schlereth, Julia, Singh, Kuldeep, Sun, Fangxian, Tillmann, Bodo, Tolstykh, Tatiana, Weber, William, Wicke, Lena, Witzel, Sonja, Yu, Qunyan, Zhang, Yu-An, Zheng, Gang, Lager, Joanne, Nabel, Gary J, Sahin, Ugur, Wiederschain, Dmitri

“…Local immunotherapy ideally stimulates immune responses against tumors while avoiding toxicities associated with systemic administration. Current strategies…”
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Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA by Karikó, Katalin, Muramatsu, Hiromi, Ludwig, János, Weissman, Drew

“…In vitro-transcribed mRNA has great therapeutic potential to transiently express the encoded protein without the adverse effects of viral and DNA-based…”
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mRNA: Fulfilling the Promise of Gene Therapy by Weissman, Drew, Karikó, Katalin

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A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis by Krienke, Christina, Kolb, Laura, Diken, Elif, Streuber, Michael, Kirchhoff, Sarah, Bukur, Thomas, Akilli-Öztürk, Özlem, Kranz, Lena M, Berger, Hendrik, Petschenka, Jutta, Diken, Mustafa, Kreiter, Sebastian, Yogev, Nir, Waisman, Ari, Karikó, Katalin, Türeci, Özlem, Sahin, Ugur

“…The ability to control autoreactive T cells without inducing systemic immune suppression is the major goal for treatment of autoimmune diseases. The key…”
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Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine by Muramatsu, Hiromi, Lam, Kieu, Bajusz, Csaba, Laczkó, Dorottya, Karikó, Katalin, Schreiner, Petra, Martin, Alan, Lutwyche, Peter, Heyes, James, Pardi, Norbert

“…Lipid nanoparticle (LNP)-formulated nucleoside-modified mRNA vaccines have proven to be very successful in the fight against the coronavirus disease 2019…”
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A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA by Baiersdörfer, Markus, Boros, Gábor, Muramatsu, Hiromi, Mahiny, Azita, Vlatkovic, Irena, Sahin, Ugur, Karikó, Katalin

“…The increasing importance of in vitro-transcribed (IVT) mRNA for synthesizing the encoded therapeutic protein in vivo demands the manufacturing of pure mRNA…”
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The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy by Foster, Jessica B., Barrett, David M., Karikó, Katalin

“…Adoptive T cell therapy is a form of cellular therapy that utilizes human immune cells, often empowered by the expression of recombinant proteins, to attack…”
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Elimination of large tumors in mice by mRNA-encoded bispecific antibodies by Stadler, Christiane R, Bähr-Mahmud, Hayat, Celik, Leyla, Hebich, Bernhard, Roth, Alexandra S, Roth, René P, Karikó, Katalin, Türeci, Özlem, Sahin, Ugur

“…Bispecific antibodies that connect T cells with tumor cells can be delivered in the form of in vitro –transcribed pharmacologically optimized mRNA; when…”
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Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies by Pardi, Norbert, Parkhouse, Kaela, Kirkpatrick, Ericka, McMahon, Meagan, Zost, Seth J., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Krammer, Florian, Hensley, Scott E., Weissman, Drew

“…Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a…”
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Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin by Karikó, Katalin, Muramatsu, Hiromi, Keller, Jason M, Weissman, Drew

“…Advances in the optimization of in vitro-transcribed mRNA are bringing mRNA-mediated therapy closer to reality. In cultured cells, we recently achieved high…”
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Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge by Pardi, Norbert, Secreto, Anthony J., Shan, Xiaochuan, Debonera, Fotini, Glover, Joshua, Yi, Yanjie, Muramatsu, Hiromi, Ni, Houping, Mui, Barbara L., Tam, Ying K., Shaheen, Farida, Collman, Ronald G., Karikó, Katalin, Danet-Desnoyers, Gwenn A., Madden, Thomas D., Hope, Michael J., Weissman, Drew

“…Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products, however, their potential is limited by the high cost of development…”
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