Search Results - "Karig, Gunter"

Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia by Beck, Hartmut, Jeske, Mario, Thede, Kai, Stoll, Friederike, Flamme, Ingo, Akbaba, Metin, Ergüden, Jens‐Kerim, Karig, Gunter, Keldenich, Jörg, Oehme, Felix, Militzer, Hans‐Christian, Hartung, Ingo V., Thuss, Uwe

“…Small‐molecule inhibitors of hypoxia‐inducible factor prolyl hydroxylases (HIF‐PHs) are currently under clinical development as novel treatment options for…”
Get full text

C−H Activation and Palladium Migration within Biaryls under Heck Reaction Conditions by Karig, Gunter, Moon, Maria-Teresa, Thasana, Nopporn, Gallagher, Timothy

“…Biaryl bromides such as 1 (RNO2, H, OMe) undergo the Heck reaction to give both the expected products 3 (“retention”) as well as “crossover” products 4…”
Get full text

Front Cover: Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia (ChemMedChem 10/2018) by Beck, Hartmut, Jeske, Mario, Thede, Kai, Stoll, Friederike, Flamme, Ingo, Akbaba, Metin, Ergüden, Jens‐Kerim, Karig, Gunter, Keldenich, Jörg, Oehme, Felix, Militzer, Hans‐Christian, Hartung, Ingo V., Thuss, Uwe

“…The Front Cover shows key elements of the pharmacological action of molidustat, a novel small‐molecule inhibitor of the hypoxia‐inducible factor prolyl…”
Get full text

New Solutions to the C-12,13 Stereoproblem of Epothilones B and D; Synthesis of a 12,13-Diol-Acetonide Epothilone B Analog by Gaich, Tanja, Karig, Gunter, Martin, Harry J., Mulzer, Johann

“…New approaches are described to the synthesis of epothilone B and a 12,13‐diol‐acetonide derivative. Specifically the (12Z) double bond is formed…”
Get full text

Directed Deprotonation−Transmetalation as a Route to Substituted Pyridines by Karig, Gunter, Spencer, James A, Gallagher, Timothy

“…Regioselective C-4 deprotonation of 3-bromopyridine, followed by Li/Zn transmetalation and Pd-mediated coupling processes, provides a flexible entry to…”
Get full text

Synthesis and Pharmacological Characterization of Novel Analogues of the Nicotinic Acetylcholine Receptor Agonist (±)-UB-165 by Sharples, Christopher G. V, Karig, Gunter, Simpson, Graham L, Spencer, James A, Wright, Emma, Millar, Neil S, Wonnacott, Susan, Gallagher, Timothy

“…(±)-UB-165 (1) is a potent neuronal nicotinic acetylcholine receptor (nAChR) ligand, which displays functional selectivity between nAChR subtypes. Using UB-165…”
Get full text

A novel highly stereoselective total synthesis of epothilone B and of its (12 R,13 R) acetonide by Mulzer, Johann, Karig, Gunter, Pojarliev, Peter

“…Stereoselective syntheses of epothilone B ( 1) and its novel derivative 2 are described. Key steps are the formation of intermediate 3 via Sharpless…”
Get full text

Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with α7 selectivity by Karig, Gunter, Large, Jonathan M., Sharples, Christopher G.V., Sutherland, Andrew, Gallagher, Timothy, Wonnacott, Susan

“…Four racemic phenyl-substituted analogues 3– 6 of the potent nicotinic agonist UB-165 1 have been synthesised and evaluated against the α 4β 2, α 3β 4, and α 7…”
Get full text

Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity by Karig, Gunter, Large, Jonathan M, Sharples, Christopher G V, Sutherland, Andrew, Gallagher, Timothy, Wonnacott, Susan

“…Four racemic phenyl-substituted analogues 3-6 of the potent nicotinic agonist UB-165 1 have been synthesised and evaluated against the alpha(4)beta(2),…”
Get full text

δ-Peptide Analogues of Pyranosyl-RNA, Part 1, Nucleo-δ-peptides Derived from Conformationally Constrained Nucleo-δ-amino Acids: Preparation of Monomers by Karig, Gunter, Fuchs, Andreas, Büsing, Arne, Brandstetter, Tilmann, Scherer, Stefan, Bats, Jan W., Eschenmoser, Albert, Quinkert, Gerhard

“…Cyclic nucleo‐δ‐amino acids that constitute monomers of a conformationally constrained nucleo‐δ‐peptide base‐pairing system have been prepared. Their synthesis…”
Get full text

d-Peptide Analogues of Pyranosyl-RNA, Part 1 , Nucleo-d-peptides Derived from Conformationally Constrained Nucleo-d-amino Acids: Preparation of Monomers by Karig, Gunter, Fuchs, Andreas, Busing, Arne, Brandstetter, Tilmann, Scherer, Stefan, Bats, Jan W, Eschenmoser, Albert, Quinkert, Gerhard

“…Cyclic nucleo-amino acids that constitute monomers of a conformationally constrained nucleo-peptide base-pairing system have been prepared. Their synthesis…”
Get full text