Search Results - "Karginov, Timofey A"

Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape by Karginov, Timofey A., Ménoret, Antoine, Vella, Anthony T.

“…Boosting T cell activation through costimulation directs defense against cancer and viral infections. Despite multiple studies targeting costimulation in…”
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IRAK4 is an immunological checkpoint in neuropsychiatric systemic lupus erythematosus by Ménoret, Antoine, Agliano, Federica, Karginov, Timofey A., Hu, Xiangyou, Vella, Anthony T.

“…The search for dementia treatments, including treatments for neuropsychiatric lupus (NPSLE), has not yet uncovered useful therapeutic targets that mitigate…”
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Antigen-specific downregulation of miR-150 in CD4 T cells promotes cell survival by Ménoret, Antoine, Agliano, Federica, Karginov, Timofey A, Karlinsey, Keaton S, Zhou, Beiyan, Vella, Anthony T

“…MicroRNA-150 (miR-150) has been shown to play a general role in the immune system, but very little is known about its role on CD4 T cell responses. During T…”
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Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling by Agliano, Federica, Karginov, Timofey A., Ménoret, Antoine, Provatas, Anthony, Vella, Anthony T.

“…Nicotinamide (NAM) shapes T cell responses but its precise molecular mechanism of action remains elusive. Here, we show that NAM impairs naive T cell effector…”
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Mammalian Polycistronic mRNAs and Disease by Karginov, Timofey A, Pastor, Daniel Parviz Hejazi, Semler, Bert L, Gomez, Christopher M

“…Our understanding of gene expression has come far since the ‘one-gene one-polypeptide’ hypothesis proposed by Beadle and Tatum. In this review, we address the…”
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Autoregulated splicing of TRA2 β programs T cell fate in response to antigen-receptor stimulation by Karginov, Timofey A, Ménoret, Antoine, Leclair, Nathan K, Harrison, Andrew G, Chandiran, Karthik, Suarez-Ramirez, Jenny E, Yurieva, Marina, Karlinsey, Keaton, Wang, Penghua, O'Neill, Rachel J, Murphy, Patrick A, Adler, Adam J, Cauley, Linda S, Anczuków, Olga, Zhou, Beiyan, Vella, Anthony T

“…T cell receptor (TCR) sensitivity to peptide-major histocompatibility complex (MHC) dictates T cell fate. Canonical models of TCR sensitivity cannot be fully…”
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The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity by Harrison, Andrew G, Yang, Duomeng, Cahoon, Jason G, Geng, Tingting, Karginov, Timofey A, Torrance, Blake L, Chiari, Conner C, Haynes, Laura, Vella, Anthony T, Witczak, Carol A, Bogan, Jonathan S, Wang, Penghua

“…The current dogma of RIG-I-like receptor (RLR) regulation states that dysregulated interferon (IFN) production is predominantly repressed by reversible…”
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UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling by Harrison, Andrew G, Yang, Duomeng, Cahoon, Jason G, Geng, Tingting, Cao, Ziming, Karginov, Timofey A, Hu, Youjia, Li, Xin, Chiari, Conner C, Qyang, Yibing, Vella, Anthony T, Fan, Zhichao, Vanaja, Sivapriya Kailasan, Rathinam, Vijay A, Witczak, Carol A, Bogan, Jonathan S, Wang, Penghua

“…The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also triggers glycolytic reprogramming…”
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