Search Results - "Kargar, Catherine"

Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans by De Ceuninck, Frédéric, Kargar, Catherine, Ilic, Catherine, Caliez, Audrey, Rolin, Jean‐Olivier, Umbdenstock, Thierry, Vinson, Cédric, Combettes, Murielle, Fanti, Brant, Harley, Elizabeth, Sadlo, Marjorie, Lefèvre, Anne‐Laure, Broux, Olivier, Wierzbicki, Michel, Fourquez, Jean‐Marie, Perron‐Sierra, Françoise, Kotschy, András, Ktorza, Alain

“…Background and Purpose Small‐molecule glucokinase activators (GKAs) are currently being investigated as therapeutic options for the treatment of type 2…”
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Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker by Karaca, Melis, Castel, Julien, Tourrel-Cuzin, Cécile, Brun, Manuel, Géant, Anne, Dubois, Mathilde, Catesson, Sandra, Rodriguez, Marianne, Luquet, Serge, Cattan, Pierre, Lockhart, Brian, Lang, Jochen, Ktorza, Alain, Magnan, Christophe, Kargar, Catherine

“…The mass of pancreatic beta-cells varies according to increases in insulin demand. It is hypothesized that functionally heterogeneous beta-cell subpopulations…”
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Dynamic Changes in β-Cell Mass and Pancreatic Insulin During the Evolution of Nutrition-Dependent Diabetes in Psammomys obesus by Kaiser, Nurit, Yuli, Michal, Üçkaya, Gökhan, Oprescu, Andrei I., Berthault, Marie-France, Kargar, Catherine, Donath, Marc Y., Cerasi, Erol, Ktorza, Alain

“…Dynamic Changes in β-Cell Mass and Pancreatic Insulin During the Evolution of Nutrition-Dependent Diabetes in Psammomys obesus Impact of Glycemic Control Nurit…”
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Newly approved and promising antidiabetic agents by Combettes, Murielle, Kargar, Catherine

“…Type 2 diabetes is an endocrine/metabolic disease characterized by hyperglycemia. It is now well established that insulin resistance and pancreatic beta-cell…”
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Anatomical versus functional β-cell mass in experimental diabetes by Kargar, C, Ktorza, A

“…The ability of pancreatic β-cell mass to vary according to insulin requirements is an important component of optimal long-term control of glucose homeostasis…”
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Endocrine pancreas plasticity under physiological and pathological conditions by Bernard-Kargar, C, Ktorza, A

“…Endocrine pancreas plasticity may be defined as the ability of the organ to adapt the beta-cell mass to the variations in insulin demand. For example, during…”
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S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice by De Ceuninck, Frédéric, Kargar, Catherine, Charton, Yves, Goldstein, Solo, Perron‐Sierra, Françoise, Ilic, Catherine, Caliez, Audrey, Rolin, Jean‐Olivier, Sadlo, Marjorie, Harley, Elizabeth, Vinson, Cédric, Ktorza, Alain

“…Background and Purpose Small molecule glucokinase activators (GKAs) have been associated with potent antidiabetic efficacy and hepatic steatosis in rodents…”
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Specific and Combined Effects of Insulin and Glucose on Functional Pancreatic β-Cell Mass in Vivo in Adult Rats by Paris, Maryline, Bernard-Kargar, Catherine, Berthault, Marie-France, Bouwens, Luc, Ktorza, Alain

“…We investigated the specific and associated effects of insulin and glucose on β-cell growth and function in adult rats. By combining simultaneous infusion…”
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Dynamic changes in β-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in Psammomys obesus: Impact of glycemic control by KAISER, Nurit, YULI, Michal, ÜCKAYA, Gökhan, OPRESCU, Andrei I, BERTHAULT, Marie-France, KARGAR, Catherine, DONATH, Marc Y, CERASI, Erol, KTORZA, Alain

“…Recent studies ascribe a major role to pancreatic beta-cell loss in type 2 diabetes. We investigated the dynamics of beta-cell mass during diabetes evolution…”
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Exploring Functional [beta]-Cell Heterogeneity In Vivo Using PSA-NCAM as a Specific Marker by Karaca, Melis, Castel, Julien, Tourrel-Cuzin, Cécile, Brun, Manuel, Géant, Anne, Dubois, Mathilde, Catesson, Sandra, Rodriguez, Marianne, Luquet, Serge, Cattan, Pierre, Lockhart, Brian, Lang, Jochen, Ktorza, Alain, Magnan, Christophe, Kargar, Catherine

“…Background The mass of pancreatic [beta]-cells varies according to increases in insulin demand. It is hypothesized that functionally heterogeneous [beta]-cell…”
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Endocrine Pancreas Plasticity Under Physiological and Pathological Conditions by Bernard-Kargar, Catherine, Ktorza, Alain

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Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control by Kaiser, Nurit, Yuli, Michal, Uçkaya, Gökhan, Oprescu, Andrei I, Berthault, Marie-France, Kargar, Catherine, Donath, Marc Y, Cerasi, Erol, Ktorza, Alain

“…Recent studies ascribe a major role to pancreatic beta-cell loss in type 2 diabetes. We investigated the dynamics of beta-cell mass during diabetes evolution…”
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specific and combined effects of insulin and glucose on functionnal pancreatic b-cell mass in vivo in adults rats by Berthault, Marie France, Paris, Maryline, Bernard-Kargar, Catherine, Bouwens, Luc, Ktorza, Alain

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Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity by BERNARD-KARGAR, Catherine, KASSIS, Nadim, BERTHAULT, Marie-France, PRALONG, William, KTORZA, Alain

“…To clarify the relationship between variations in beta-cell mass and pancreatic function, we investigated the possibility to analyze, quantify, and sort…”
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Sialylated form of the neural cell adhesion molecule (NCAM): A new tool for the identification and sorting of (Beta)-cell subpopulations with different functional by Bernard-Kargar, Catherine, Kassis, Nadim, Marie-France Berthault, Pralong, William, Ktorza, Alain

“…To clarify the relationship between variations in beta-cell mass and pancreatic function, we investigated the possibility to analyze, quantify, and sort…”
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Sialylated Form of the Neural Cell Adhesion Molecule : A New Tool for the Identification and Sorting of Β-Cell Subpopulations With Different Functional Activity by Bernard-Kargar, Catherine, Kassis, Nadim, Berthault, Marie-France, Pralong, William, Ktorza, Alain

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Sialylated Form of the Neural Cell Adhesion Molecule : A New Tool for the Identification and Sorting of [Beta]-Cell Subpopulations With Different Functional Activity by Bernard-Kargar, Catherine, Kassis, Nadim, Berthault, Marie-France, Pralong, William, Ktorza, Alain

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Role of glucose in IRS signaling in rat pancreatic islets: specific effects and interplay with insulin by Paris, Maryline, Bernard-Kargar, Catherine, Vilar, José, Kassis, Nadim, Ktorza, Alain

“…We investigated the possible interplay between insulin and glucose signaling pathways in rat pancreatic beta-cell with a special focus on the role of glucose…”
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