Search Results - "Kareva, Irina"

Metabolism and Gut Microbiota in Cancer Immunoediting, CD8/Treg Ratios, Immune Cell Homeostasis, and Cancer (Immuno)Therapy: Concise Review by Kareva, Irina

“…The concept of immunoediting, a process whereby the immune system eliminates immunogenic cancer cell clones, allowing the remaining cells to progress and form…”
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A Combination of Immune Checkpoint Inhibition with Metronomic Chemotherapy as a Way of Targeting Therapy-Resistant Cancer Cells by Kareva, Irina

“…Therapeutic resistance remains a major obstacle in treating many cancers, particularly in advanced stages. It is likely that cytotoxic lymphocytes (CTLs) have…”
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Immune Suppression in Pregnancy and Cancer: Parallels and Insights by Kareva, Irina

“…Immune system has evolved to maintain homeostatic balance between effector and regulatory immunity, which is critical to both elicit an adequate protective…”
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From Hyperinsulinemia to Cancer Progression: How Diminishing Glucose Storage Capacity Fuels Insulin Resistance by Kareva, Irina

“…ABSTRACT Background Type 2 diabetes (T2D) is a complex metabolic disorder characterized by insulin resistance, hyperglycemia, and hyperinsulinemia. A…”
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Serotonin Signaling in the Enteric Nervous System and Connection to Autism Spectrum Disorder: A Translational Mathematical Model by Kareva, Irina

“…While the causes of autism spectrum disorder (ASD) remain unclear, some studies have shown that serotonin-mediated effects on the enteric nervous system (ENS)…”
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Understanding Metabolic Alterations in Cancer Cachexia through the Lens of Exercise Physiology by Kareva, Irina

“…Cancer cachexia is one of the leading causes of mortality for late-stage cancer patients. One of its key characteristics is abnormal metabolism and loss of…”
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Prisoner's dilemma in cancer metabolism by Kareva, Irina

“…As tumors outgrow their blood supply and become oxygen deprived, they switch to less energetically efficient but oxygen-independent anaerobic glucose…”
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The Emerging Hallmarks of Metabolic Reprogramming and Immune Evasion: Distinct or Linked? by KAREVA, Irina, HAHNFELDT, Philip

“…The role of the immune system in tumor elimination has been shown to be increasingly ambiguous, as many tumors not only escape recognition by the adaptive…”
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Biological stoichiometry in tumor micro-environments by Kareva, Irina

“…Tumors can be viewed as evolving ecological systems, in which heterogeneous populations of cancer cells compete with each other and somatic cells for space and…”
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How Should Cancer Models Be Constructed? by Beckman, Robert A., Kareva, Irina, Adler, Frederick R.

“…Choosing and optimizing treatment strategies for cancer requires capturing its complex dynamics sufficiently well for understanding but without being…”
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Guiding model‐driven combination dose selection using multi‐objective synergy optimization by Gevertz, Jana L., Kareva, Irina

“…Despite the growing appreciation that the future of cancer treatment lies in combination therapies, finding the right drugs to combine and the optimal way to…”
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Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition by Kareva, Irina, Abou-Slaybi, Abdo, Dodd, Oliver, Dashevsky, Olga, Klement, Giannoula Lakka

“…Both normal wound healing and tumor angiogenesis are mitigated by the sequential, carefully orchestrated release of growth stimulators and inhibitors. These…”
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Tumors induce complex DNA damage in distant proliferative tissues in vivo by Redon, Christophe E., Dickey, Jennifer S., Nakamura, Asako J., Kareva, Irina G., Naf, Dieter, Nowsheen, Somaira, Kryston, Thomas B., Bonner, William M., Georgakilas, Alexandros G., Sedelnikova, Olga A., Hanawalt, Philip C.

“…That tumors cause changes in surrounding tissues is well documented, but whether they also affect distant tissues is uncertain. Such knowledge may be important…”
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Estrogen as an Essential Resource and the Coexistence of ER+ and ER– Cancer Cells by Kareva, Irina, Brown, Joel S.

“…Diagnosis of estrogen sensitivity in breast cancer is largely predicated on the ratio of ER + and ER – cancer cells obtained from biopsies. Estrogen is a…”
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Mitigating non-genetic resistance to checkpoint inhibition based on multiple states of immune exhaustion by Kareva, Irina, Gevertz, Jana L.

“…Despite the revolutionary impact of immune checkpoint inhibition on cancer therapy, the lack of response in a subset of patients, as well as the emergence of…”
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Minimally sufficient experimental design using identifiability analysis by Gevertz, Jana L., Kareva, Irina

“…Mathematical models are increasingly being developed and calibrated in tandem with data collection, empowering scientists to intervene in real time based on…”
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Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One? by Kareva, Irina, Luddy, Kimberly A, O'Farrelly, Cliona, Gatenby, Robert A, Brown, Joel S

“…Tumor-immune interactions are often framed as predator-prey. This imperfect analogy describes how immune cells (the predators) hunt and kill immunogenic tumor…”
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Identifying key questions in the ecology and evolution of cancer by Dujon, Antoine M., Aktipis, Athena, Alix‐Panabières, Catherine, Amend, Sarah R., Boddy, Amy M., Brown, Joel S., Capp, Jean‐Pascal, DeGregori, James, Ewald, Paul, Gatenby, Robert, Gerlinger, Marco, Giraudeau, Mathieu, Hamede, Rodrigo K., Hansen, Elsa, Kareva, Irina, Maley, Carlo C., Marusyk, Andriy, McGranahan, Nicholas, Metzger, Michael J., Nedelcu, Aurora M., Noble, Robert, Nunney, Leonard, Pienta, Kenneth J., Polyak, Kornelia, Pujol, Pascal, Read, Andrew F., Roche, Benjamin, Sebens, Susanne, Solary, Eric, Staňková, Kateřina, Swain Ewald, Holly, Thomas, Frédéric, Ujvari, Beata

“…The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has…”
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Delicate Balances in Cancer Chemotherapy: Modeling Immune Recruitment and Emergence of Systemic Drug Resistance by Tran, Anh Phong, Ali Al-Radhawi, M, Kareva, Irina, Wu, Junjie, Waxman, David J, Sontag, Eduardo D

“…Metronomic chemotherapy can drastically enhance immunogenic tumor cell death. However, the mechanisms responsible are still incompletely understood. Here, we…”
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A practical guide for the generation of model-based virtual clinical trials by Craig, Morgan, Gevertz, Jana L., Kareva, Irina, Wilkie, Kathleen P.

“…Mathematical modeling has made significant contributions to drug design, development, and optimization. Virtual clinical trials that integrate mathematical…”
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