Search Results - "Karess, Roger E."
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Beclin-1 is required for chromosome congression and proper outer kinetochore assembly
Published in EMBO reports (01-04-2013)“…The functions of Beclin‐1 in macroautophagy, tumorigenesis and cytokinesis are thought to be mediated by its association with the PI3K‐III complex. Here, we…”
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2
Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila
Published in Open biology (17-10-2018)“…The Mad1 spindle checkpoint protein helps organize several nucleoplasmic components, and flies lacking Mad1 present changes in gene expression reflecting…”
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Recruitment of Mad2 to the Kinetochore Requires the Rod/Zw10 Complex
Published in Current biology (10-05-2005)“…Compromising the activity of the spindle checkpoint permits mitotic exit in the presence of unattached kinetochores and, consequently, greatly increases the…”
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4
Inducing "cytokinesis" without mitosis in unfertilized Drosophila eggs
Published in Cell cycle (Georgetown, Tex.) (01-08-2012)“…Selection of the cleavage plane during cytokinesis in dividing cells is linked to the position of the mitotic spindle. A major player in cleavage plane…”
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RZZ and Mad1 dynamics in Drosophila mitosis
Published in Chromosome research (01-06-2015)“…The presence or absence of Mad1 at kinetochores is a major determinant of spindle assembly checkpoint (SAC) activity, the surveillance mechanism that delays…”
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6
A mitotic role for Mad1 beyond the spindle checkpoint
Published in Journal of cell science (15-05-2011)“…Unattached kinetochores generate an anaphase inhibitor, through the spindle assembly checkpoint (SAC), that allows cells more time to establish proper…”
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Mutations in the Drosophila rough deal gene affecting RZZ kinetochore function
Published in Biology of the cell (01-10-2020)“…Background The RZZ complex, composed of the proteins Rough‐Deal (Rod), Zw10 and Zwilch, plays a central role in the spindle assembly checkpoint (SAC), which…”
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Rough Deal and Zw10 are required for the metaphase checkpoint in Drosophila
Published in Nature cell biology (01-12-2000)“…The metaphase-anaphase transition during mitosis is carefully regulated in order to assure high-fidelity transmission of genetic information to the daughter…”
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Cenp-meta is required for sustained spindle checkpoint
Published in Biology open (15-06-2014)“…Cenp-E is a kinesin-like motor protein required for efficient end-on attachment of kinetochores to the spindle microtubules. Cenp-E immunodepletion in Xenopus…”
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Energy-dependent regulation of cell structure by AMP-activated protein kinase
Published in Nature (21-06-2007)“…AMP-activated protein kinase (AMPK, also known as SNF1A) has been primarily studied as a metabolic regulator that is activated in response to energy…”
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11
Flies without a spindle checkpoint
Published in Nature cell biology (01-05-2007)“…Mad2 has a key role in the spindle-assembly checkpoint (SAC) - the mechanism delaying anaphase onset until all chromosomes correctly attach to the spindle…”
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Microbiological and molecular screening of Candida spp. isolated from genital tract of asymptomatic pregnant women
Published in Journal of medical microbiology (01-01-2022)“…Introduction. Candida spp. may cause opportunistic infections called vulvovaginal candidiasis (VVC), which is estimated to be the second most common cause of…”
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In vivo dynamics of Drosophila nuclear envelope components
Published in Molecular biology of the cell (01-09-2008)“…Nuclear pore complexes (NPCs) are multisubunit protein entities embedded into the nuclear envelope (NE). Here, we examine the in vivo dynamics of the essential…”
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Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1
Published in Molecular biology of the cell (15-06-2012)“…Monopolar spindle 1 (Mps1) is essential for the spindle assembly checkpoint (SAC), which prevents anaphase onset in the presence of misaligned chromosomes…”
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New Insights into the Role of BubR1 in Mitosis and Beyond
Published in International Review of Cell and Molecular Biology (2013)“…BubR1 is a critical component of the spindle assembly checkpoint, the surveillance mechanism that helps maintain the high fidelity of mitotic chromosome…”
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Book Chapter Reference Journal Article -
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The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore
Published in Journal of cell science (01-09-2001)“…The zeste-white 10 (zw10) and rough deal (rod) genes of Drosophila both encode kinetochore components, and mutations in either gene greatly increase the…”
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Separating the spindle, checkpoint, and timer functions of BubR1
Published in The Journal of cell biology (30-11-2009)“…BubR1 performs several roles during mitosis, affecting the spindle assembly checkpoint (SAC), mitotic timing, and spindle function, but the interdependence of…”
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A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment
Published in Journal of cell science (15-03-2015)“…Proper kinetochore recruitment and regulation of dynein and the Mad1-Mad2 complex requires the Rod-Zw10-Zwilch (RZZ) complex. Here, we describe rod(Z3), a…”
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A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment
Published in Journal of cell science (01-08-2015)Get full text
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Response to Luca L Fava and colleagues
Published in EMBO reports (01-10-2015)“…Graphical Abstract The original authors' response…”
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