Search Results - "Karen Marshall"

Misfolded amyloid-β-42 impairs the endosomal–lysosomal pathway by Marshall, Karen E., Vadukul, Devkee M., Staras, Kevin, Serpell, Louise C.

“…Misfolding and aggregation of proteins is strongly linked to several neurodegenerative diseases, but how such species bring about their cytotoxic actions…”
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Internalisation and toxicity of amyloid‐β 1‐42 are influenced by its conformation and assembly state rather than size by Vadukul, Devkee M., Maina, Mahmoud, Franklin, Hannah, Nardecchia, Astrid, Serpell, Louise C., Marshall, Karen E.

“…Amyloid fibrils found in plaques in Alzheimer’s disease (AD) brains are composed of amyloid‐β peptides. Oligomeric amyloid‐β 1‐42 (Aβ42) is thought to play a…”
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Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid‐β 1‐42 by Vadukul, Devkee M., Gbajumo, Oyinkansola, Marshall, Karen E., Serpell, Louise C.

“…β‐amyloid 1‐42 (Aβ1‐42) is a self‐assembling peptide that goes through many conformational and morphological changes before forming the fibrils that are…”
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Feasibility and acceptability of a physical activity behavioural modification tele-coaching intervention in lung transplant recipients by Hume, Emily, Muse, Hazel, Wallace, Kirstie, Wilkinson, Mick, Heslop Marshall, Karen, Nair, Arun, Clark, Stephen, Vogiatzis, Ioannis

“…Background Despite improvements in pulmonary function following lung transplantation (LTx), physical activity levels remain significantly lower than the…”
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Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability by Marshall, Karen E, Morris, Kyle L, Charlton, Deborah, O’Reilly, Nicola, Lewis, Laurence, Walden, Helen, Serpell, Louise C

“…Amyloid-like fibrous crystals formed by the peptide KFFEAAAKKFFE have been previously characterized and provide an ideal model system to examine the importance…”
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The Common Architecture of Cross-β Amyloid by Jahn, Thomas R., Makin, O. Sumner, Morris, Kyle L., Marshall, Karen E., Tian, Pei, Sikorski, Pawel, Serpell, Louise C.

“…Amyloid fibril deposition is central to the pathology of more than 30 unrelated diseases including Alzheimer's disease and Type 2 diabetes. It is generally…”
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Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons by Marshall, Karen E, Mengham, Kurtis, Spink, Matthew C, Vania, Lyra, Pollard, Hannah Jane, Darrow, Michele C, Duke, Elizabeth, Harkiolaki, Maria, Serpell, Louise C

“…Protein misfolding is common to neurodegenerative diseases (NDs) including Alzheimer's disease (AD), which is partly characterized by the self-assembly and…”
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Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo by Marshall, Karen M., Wojciechowski, Jonathan P., Jayawarna, Vineetha, Hasan, Abshar, Echalier, Cécile, Øvrebø, Øystein, Yang, Tao, Zhou, Kun, Kanczler, Janos M., Mata, Alvaro, Salmeron-Sanchez, Manuel, Stevens, Molly M., Oreffo, Richard O. C.

“…Bone tissue engineering aims to harness materials to develop functional bone tissue to heal ‘critical-sized’ bone defects. This study examined a robust, coated…”
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Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication by Dutta, Prasun, Talenti, Andrea, Young, Rachel, Jayaraman, Siddharth, Callaby, Rebecca, Jadhav, Santosh Kumar, Dhanikachalam, Velu, Manikandan, Mayakannan, Biswa, Bhim B., Low, Wai Y., Williams, John L., Cook, Elizabeth, Toye, Phil, Wall, Eileen, Djikeng, Appolinaire, Marshall, Karen, Archibald, Alan L., Gokhale, Suresh, Kumar, Satish, Hume, David A., Prendergast, James G. D.

“…More people globally depend on the water buffalo than any other domesticated species, and as the most closely related domesticated species to cattle they can…”
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Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target by Oakley, Sebastian S, Maina, Mahmoud B, Marshall, Karen E, Al-Hilaly, Youssra K, Harrington, Charlie R, Wischik, Claude M, Serpell, Louise C

“…Tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including Alzheimer's disease, Pick's disease, chronic…”
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Livestock Genomics for Developing Countries - African Examples in Practice by Marshall, Karen, Gibson, John P, Mwai, Okeyo, Mwacharo, Joram M, Haile, Aynalem, Getachew, Tesfaye, Mrode, Raphael, Kemp, Stephen J

“…African livestock breeds are numerous and diverse, and typically well adapted to the harsh environment conditions under which they perform. They have been used…”
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Identification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population by Benavides, Magda Vieira, Sonstegard, Tad S, Kemp, Stephen, Mugambi, John M, Gibson, John P, Baker, Robert Leyden, Hanotte, Olivier, Marshall, Karen, Van Tassell, Curtis

“…Gastrointestinal (GI) parasitic infection is the main health constraint for small ruminant production, causing loss of weight and/or death. Red Maasai sheep…”
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Outpatient Single-Session Yttrium-90 Glass Microsphere Radioembolization by Gates, Vanessa L., MS, Marshall, Karen G., RN, Salzig, Krystina, RN, Williams, Melissa, RN, Lewandowski, Robert J., MD, Salem, Riad, MD, MBA

“…Abstract Purpose To investigate the feasibility of yttrium-90 (90 Y) glass microsphere radioembolization (including angiography, lung shunt assessment, and…”
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SNP panels for the estimation of dairy breed proportion and parentage assignment in African crossbred dairy cattle by Gebrehiwot, Netsanet Z, Strucken, Eva M, Marshall, Karen, Aliloo, Hassan, Gibson, John P

“…Understanding the relationship between genetic admixture and phenotypic performance is crucial for the optimization of crossbreeding programs. The use of small…”
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PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection by Marshall, Karen E, Hughson, Andrew, Vascellari, Sarah, Priola, Suzette A, Sakudo, Akikazu, Onodera, Takashi, Baron, Gerald S

“…Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP ) influences PrP misfolding into the disease-associated isoform, PrP , as well as prion…”
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Paired Helical Filament-Forming Region of Tau (297–391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells by Pollack, Saskia J., Trigg, Jasmine, Khanom, Tahmida, Biasetti, Luca, Marshall, Karen E., Al-Hilaly, Youssra K., Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.

“…Assembly of tau protein into paired helical filaments and straight filaments is a key feature of Alzheimer's disease. Aggregation of tau has been implicated in…”
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Cognitive behavioural therapy combined with physical activity behavioural modification strategies during pulmonary rehabilitation in patients with COPD by Armstrong, Matthew, Hume, Emily, McNeillie, Laura, Chambers, Francesca, Wakenshaw, Lynsey, Burns, Graham, Heslop Marshall, Karen, Vogiatzis, Ioannis

“…IntroductionPatients with COPD who exhibit elevated levels of anxiety and/or depression are typically less able to improve symptoms and physical activity…”
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A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration by Marshall, Karen E., Vadukul, Devkee M., Dahal, Liza, Theisen, Alina, Fowler, Milena W., Al-Hilaly, Youssra, Ford, Lenzie, Kemenes, György, Day, Iain J., Staras, Kevin, Serpell, Louise C.

“…Amyloid β1-42 (Aβ1-42) plays a central role in Alzheimer’s disease. The link between structure, assembly and neuronal toxicity of this peptide is of major…”
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Tailored, psychological intervention for anxiety or depression in people with chronic obstructive pulmonary disease (COPD), TANDEM (Tailored intervention for ANxiety and DEpression Management in COPD): protocol for a randomised controlled trial by Sohanpal, Ratna, Pinnock, Hilary, Steed, Liz, Heslop Marshall, Karen, Chan, Claire, Kelly, Moira, Priebe, Stefan, Roberts, C Michael, Singh, Sally, Smuk, Melanie, Saqi-Waseem, Sarah, Healey, Andy, Underwood, Martin, White, Patrick, Warburton, Chris, Taylor, Stephanie J C

“…People with chronic obstructive pulmonary disease (COPD) are at increased risk of depression and anxiety, which greatly reduces their quality of life and is…”
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Impact of COVID-19 shielding on physical activity and quality of life in patients with COPD by Hume, Emily, Armstrong, Matthew, Manifield, James, McNeillie, Laura, Chambers, Francesca, Wakenshaw, Lynsey, Burns, Graham, Heslop Marshall, Karen, Vogiatzis, Ioannis

“…https://bit.ly/30gQEpG…”
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