Search Results - "Karem Cobas"
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Screening for immune response against Dengue virus in Vietnamese non‐human primates: implications for vaccine developers
Published in Clinical & translational immunology (01-03-2017)“…One of the major problems faced for the development of a vaccine against Dengue virus is the lack of a suitable animal model. Although non‐human primates do…”
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Evaluation in Mice of the Immunogenicity of a Tetravalent Subunit Vaccine Candidate Against Dengue Virus Using Mucosal and Parenteral Immunization Routes
Published in Viral immunology (01-06-2017)“…Our group has developed a subunit vaccine candidate against Dengue virus (DENV) based on two different viral regions, the domain III of the envelope protein…”
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Esquemas de inmunización complementaria basados en la combinación de una formulación tetravalente de proteínas recombinantes y virus vivos atenuados: estrategia vacunal contra el dengue
Published in Anales de la Academia de Ciencias de Cuba (01-08-2021)“…RESUMEN Introducción: El dengue es una de las enfermedades más importantes trasmitida por mosquitos; sin embargo, solo existe una vacuna licenciada, la cual…”
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Recombinant protein based on domain III and capsid regions of zika virus induces humoral and cellular immune response in immunocompetent BALB/c mice
Published in Vaccine (15-09-2023)“…Zika virus infection continues to be a global concern for human health due to the high-risk association of the disease with neurological disorders and…”
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Addition of nucleotide adjuvants enhances the immunogenicity of a recombinant subunit vaccine against the Zika virus in BALB/c mice
Published in Vaccine (14-11-2024)“…Zika virus (ZIKV) infection remains a global public health problem. After the “Public Health Emergencies of International Concern” declared in February 2016,…”
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A Tetravalent Formulation Based on Recombinant Nucleocapsid-like Particles from Dengue Viruses Induces a Functional Immune Response in Mice and Monkeys
Published in The Journal of immunology (1950) (01-11-2016)“…Despite the considerable effort that has been invested in elucidating the mechanisms of protection and immunopathogenesis associated with dengue virus…”
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A heterologous prime-boost strategy for immunization against Dengue virus combining the Tetra DIIIC subunit vaccine candidate with the TV005 live-attenuated tetravalent vaccine
Published in Journal of general virology (01-06-2019)“…The development of live-attenuated vaccines against Dengue virus (DENV) has been problematic. Dengvaxia, licensed in several countries where DENV is endemic,…”
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A dose-response study in mice of a tetravalent vaccine candidate composed of domain III-capsid proteins from dengue viruses
Published in Archives of virology (01-08-2017)“…Tetra DIIIC is a subunit vaccine candidate based on domain III of the envelope protein and the capsid protein of the four serotypes of dengue virus. This…”
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Immunization of mice with Neisseria meningitidis serogroup B genomic expression libraries elicits functional antibodies and reduces the level of bacteremia in an infant rat infection model
Published in Vaccine (04-01-2005)“…The feasibility of expression library immunization against the pathogenic bacterium Neisseria meningitidis was studied. A genomic library of N. meningitidis…”
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Identification of new meningococcal serogroup B surface antigens through a systematic analysis of neisserial genomes
Published in Vaccine (11-12-2009)“…Abstract The difficulty of inducing an effective immune response against the Neisseria meningitidis serogroup B capsular polysaccharide has lead to the search…”
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The tetravalent formulation of domain III‐capsid proteins recalls memory B‐ and T‐cell responses induced in monkeys by an experimental dengue virus infection
Published in Clinical & translational immunology (01-06-2017)“…Tetra DIIIC is a vaccine candidate against dengue virus (DENV) composed by four chimeric proteins that fuse the domain III of the envelope protein of each…”
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Lipoprotein NMB0928 from Neisseria meningitidis serogroup B as a novel vaccine candidate
Published in Vaccine (05-12-2007)“…Abstract Polysaccharide-based vaccines for serogroup B Neisseria meningitidis have failed to induce protective immunity. As a result, efforts to develop…”
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Identification and characterization of phage-displayed peptide mimetics of Neisseria meningitidis serogroup B capsular polysaccharide
Published in International journal of medical microbiology (01-01-2011)“…Abstract Neisseria meningitidis causes meningitis and septicemia. There is no single vaccine against all serogroup B meningococcal (MenB) strains up to now…”
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Neisseria meningitidis antigen NMB0088: sequence variability, protein topology and vaccine potential
Published in Journal of medical microbiology (01-02-2009)“…1 Meningococcal Research Department, Division of Vaccines, Center for Genetic Engineering and Biotechnology, Avenue 31, Cubanacan, Habana 10600, Cuba 2…”
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Assessment of vaccine potential of the Neisseria -specific protein NMB0938
Published in Vaccine (16-11-2009)“…Abstract The availability of complete genome sequence of Neisseria meningitidis serogroup B strain MC58 and reverse vaccinology has allowed the discovery of…”
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Identification of new meningococcal serogroup B surface antigens through a systematic analysis of neisserial genomes
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Assessment of vaccine potential of theNeisseria-specific protein NMB0938
Published in Vaccine (16-11-2009)“…The availability of complete genome sequence ofNeisseria meningitidisserogroup B strain MC58 and reverse vaccinology has allowed the discovery of several novel…”
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Identification by genomic immunization of a pool of DNA vaccine candidates that confer protective immunity in mice against Neisseria meningitidis serogroup B
Published in Vaccine (09-07-2007)“…Abstract We have shown previously that expression library immunization is viable alternative approach to induce protective immunity against Neisseria…”
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Lipoprotein NMB0928 fromNeisseria meningitidisserogroup B as a novel vaccine candidate
Published in Vaccine (05-12-2007)“…Polysaccharide-based vaccines for serogroup BNeisseria meningitidishave failed to induce protective immunity. As a result, efforts to develop vaccines for…”
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20
Immunization with Neisseria meningitidis outer membrane vesicles prevents bacteremia in neonatal mice
Published in Vaccine (06-03-2006)“…Although vaccines based on outer membrane vesicles (OMV) of Neisseria meningitidis have been developed and administered to children, little is known about the…”
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