Neuropeptide Y directly affects ovarian cell proliferation and apoptosis

Abstract The effects of neuropeptide Y (NPY; 0, 10, 100 and 1000 ng/mL) on the expression of PCNA, bax and p53 were examined by immunocytochemistry in porcine luteinized granulosa cells. NPY inhibited proliferation as well as promoted apoptosis and accumulation of p53 in the cells. This is the first...

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Bibliographic Details
Published in:	Reproductive biology Vol. 15; no. 4; pp. 257 - 260
Main Authors:	Sirotkin, Alexander V, Kardošová, Diana, Alwasel, Saleh Hamad, Harrath, Abdel Halim
Format:	Journal Article
Language:	English
Published:	Poland Elsevier Urban & Partner Sp. z o.o 01-12-2015
Subjects:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Cell Proliferation - drug effects Cell Proliferation - physiology Dose-Response Relationship, Drug Female Gene Expression Regulation - drug effects Granulosa Cells - drug effects Granulosa Cells - physiology Neuropeptide Y Neuropeptide Y - administration & dosage Neuropeptide Y - pharmacology Obstetrics and Gynecology Ovary Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Proliferation Swine Transcription factor p53 Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Neuropeptide Y Ovary Transcription factor p53 Proliferation Apoptosis
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Summary:	Abstract The effects of neuropeptide Y (NPY; 0, 10, 100 and 1000 ng/mL) on the expression of PCNA, bax and p53 were examined by immunocytochemistry in porcine luteinized granulosa cells. NPY inhibited proliferation as well as promoted apoptosis and accumulation of p53 in the cells. This is the first report to demonstrate the direct action of NPY on ovarian cell proliferation and apoptosis. The results of the study suggest that the effect is mediated by transcription factor p53.
ISSN:	1642-431X 2300-732X
DOI:	10.1016/j.repbio.2015.07.004