Methylenetetrahydrofolate reductase C677T and a1298C polymorphism in Iranian women with idiopathic recurrent pregnancy losses
Background : Recurrent pregnancy loss (RPL) is a serious problem for pregnancy. There is evidence that vascular complications play a principal role in RPL. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Polymorphisms (C677T, A1298C) of MTHFR gene are associated wit...
Saved in:
| Published in: | Iranian red crescent medical journal Vol. 16; no. 7; pp. 1 - 4 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Dubai, United Arab Emirates
Iranian Hospital
01-07-2014
Zamen Salamati Publishing Kowsar |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background : Recurrent pregnancy loss (RPL) is a serious problem for pregnancy. There is evidence that vascular complications play a principal role in RPL. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Polymorphisms (C677T, A1298C) of MTHFR gene are associated with decreased MTHFR activity. Objectives : The aim of this study was to determine the association between MTHFR polymorphisms (C677T and A1298C) and recurrent pregnancy loss (RPL) in Iranian women. Materials and Methods : In this case-control study, blood samples were obtained from patients who had three or more consecutive pregnancy losses before the 22nd week of pregnancy (n = 204). The control group consisted of 116 age-matched women with at least one alive child and without any history of pregnancy loss or other gestational complications (n = 116). Following DNA extraction, samples were tested for MTHFR C677T and A1298C polymorphisms using the reverse hybridization method. Results : The prevalence of 677TT mutation was 8.8% (18 / 204) in the patient group and 8.6 % (10 / 116) in the control group (P = 0.434). The prevalence of 1298CC mutation was 12.3 % (25 / 204) in the patient group and 8 % (9 / 116) in the control group (P = 0.155). Investigation of the distributions of various genotypes of MTHFR C677T and A1298C did not indicate a significant difference between patients with RPL and healthy control subjects. Conclusions : The results suggest that MTHFR mutations might not be associated with RPL in the examined population. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2074-1804 2074-1812 |
| DOI: | 10.5812/ircmj.16763 |