Search Results - "Karcz, Tadeusz"

UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia by Karcz, Tadeusz P, Whitehead, Gregory S, Nakano, Keiko, Nakano, Hideki, Grimm, Sara A, Williams, Jason G, Deterding, Leesa J, Jacobson, Kenneth A, Cook, Donald N

“…Airway eosinophilia is a hallmark of allergic asthma and is associated with mucus production, airway hyperresponsiveness, and shortness of breath. Although…”
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Thermal behavior and determination of physicochemical properties of novel candidates for antipsychotic drugs by Stępnicki, Piotr, Gwarda, Radosław Ł., Bartyzel, Agata, Karcz, Tadeusz, Szczepańska, Katarzyna, Wróbel, Tomasz M., Kaczor, Agnieszka A.

“…Treatment of schizophrenia with currently available drugs is often ineffective or results in several adverse reactions. In previous studies focusing on the…”
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Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist by Wen, Zhiwei, Salmaso, Veronica, Jung, Young-Hwan, Phung, Ngan B, Gopinatth, Varun, Shah, Qasim, Patterson, Alexandra T, Randle, John C. R, Chen, Zhoumou, Salvemini, Daniela, Lieberman, David I, Whitehead, Gregory S, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A

“…High affinity phenyl-piperidine P2Y14R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity…”
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Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y 14 R Antagonist by Wen, Zhiwei, Salmaso, Veronica, Jung, Young-Hwan, Phung, Ngan B, Gopinatth, Varun, Shah, Qasim, Patterson, Alexandra T, Randle, John C R, Chen, Zhoumou, Salvemini, Daniela, Lieberman, David I, Whitehead, Gregory S, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A

“…High affinity phenyl-piperidine P2Y R antagonist (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various…”
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Trisubstituted 1,3,5-Triazines as Histamine H4 Receptor Antagonists with Promising Activity In Vivo by Olejarz-Maciej, Agnieszka, Mogilski, Szczepan, Karcz, Tadeusz, Werner, Tobias, Kamińska, Katarzyna, Kupczyk, Jarosław, Honkisz-Orzechowska, Ewelina, Latacz, Gniewomir, Stark, Holger, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota

“…Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H4 receptor (H4R) is a promising target for the treatment of…”
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AR71, Histamine H3 Receptor Ligand—In Vitro and In Vivo Evaluation (Anti-Inflammatory Activity, Metabolic Stability, Toxicity, and Analgesic Action) by Stasiak, Anna, Honkisz-Orzechowska, Ewelina, Gajda, Zbigniew, Wagner, Waldemar, Popiołek-Barczyk, Katarzyna, Kuder, Kamil J., Latacz, Gniewomir, Juszczak, Michał, Woźniak, Katarzyna, Karcz, Tadeusz, Szczepańska, Katarzyna, Jóźwiak-Bębenista, Marta, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota

“…The future of therapy for neurodegenerative diseases (NDs) relies on new strategies targeting multiple pharmacological pathways. Our research led to obtaining…”
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Structure-Activity Relationship of Heterocyclic P2Y 14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres by Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M, Phung, Ngan B, Lieberman, David I, Gopinatth, Varun, Randle, John C R, Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A

“…A known zwitterionic, heterocyclic P2Y R antagonist was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a…”
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Structure–Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres by Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M, Phung, Ngan B, Lieberman, David I, Gopinatth, Varun, Randle, John C. R, Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A

“…A known zwitterionic, heterocyclic P2Y14R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a…”
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Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core by Jung, Young-Hwan, Yu, Jinha, Wen, Zhiwei, Salmaso, Veronica, Karcz, Tadeusz P, Phung, Ngan B, Chen, Zhoumou, Duca, Sierra, Bennett, John M, Dudas, Steven, Salvemini, Daniela, Gao, Zhan-Guo, Cook, Donald N, Jacobson, Kenneth A

“…Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl P2Y14 receptor (P2Y14R) antagonists were synthesized, and affinity was measured in…”
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Exploration of Alternative Scaffolds for P2Y 14 Receptor Antagonists Containing a Biaryl Core by Jung, Young-Hwan, Yu, Jinha, Wen, Zhiwei, Salmaso, Veronica, Karcz, Tadeusz P, Phung, Ngan B, Chen, Zhoumou, Duca, Sierra, Bennett, John M, Dudas, Steven, Salvemini, Daniela, Gao, Zhan-Guo, Cook, Donald N, Jacobson, Kenneth A

“…Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl P2Y receptor (P2Y R) antagonists were synthesized, and affinity was measured in P2Y…”
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Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes by Bartuzi, Damian, Kędzierska, Ewa, Targowska-Duda, Katarzyna M., Koszła, Oliwia, Wróbel, Tomasz M., Jademyr, Simon, Karcz, Tadeusz, Szczepańska, Katarzyna, Stępnicki, Piotr, Wronikowska-Denysiuk, Olga, Biała, Grażyna, Handzlik, Jadwiga, Kristensen, Jesper L., Poso, Antti, Kaczor, Agnieszka A.

“…Anxiety is a troublesome symptom for many patients, especially those suffering from schizophrenia. Its regulation involves serotonin receptors, targeted e.g…”
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Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors by Łażewska, Dorota, Olejarz-Maciej, Agnieszka, Reiner, David, Kaleta, Maria, Latacz, Gniewomir, Zygmunt, Małgorzata, Doroz-Płonka, Agata, Karcz, Tadeusz, Frank, Annika, Stark, Holger, Kieć-Kononowicz, Katarzyna

“…Dual target ligands are a promising concept for the treatment of Parkinson’s disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with…”
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Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis by Jain, Shanu, Pydi, Sai P, Jung, Young-Hwan, Scortichini, Mirko, Kesner, Efrat L, Karcz, Tadeusz P, Cook, Donald N, Gavrilova, Oksana, Wess, Jürgen, Jacobson, Kenneth A

“…Obesity is the major driver of the worldwide epidemic in type 2 diabetes (T2D). In the obese state, chronically elevated plasma free fatty acid levels…”
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Xanthine-Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases by Załuski, Michał, Karcz, Tadeusz, Drabczyńska, Anna, Vielmuth, Christin, Olejarz-Maciej, Agnieszka, Głuch-Lutwin, Monika, Mordyl, Barbara, Siwek, Agata, Satała, Grzegorz, Müller, Christa E, Kieć-Kononowicz, Katarzyna

“…Multitarget drugs based on a hybrid dopamine-xanthine core were designed as potential drug candidates for the treatment of neurodegenerative diseases…”
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Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55 by Rempel, Viktor, Fuchs, Alexander, Hinz, Sonja, Karcz, Tadeusz, Lehr, Matthias, Koetter, Uwe, Müller, Christa E

“…The bark of Magnolia officinalis is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. We found that…”
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Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice by Whitehead, Gregory S., Karcz, Tadeusz P., Tosh, Dilip K., Jung, Young-Hwan, Wen, Zhiwei, Campbell, Ryan G., Gopinatth, Varun, Gao, Zhan-Guo, Jacobson, Kenneth A., Cook, Donald N.

“…COVID-19 disease is associated with progressive accumulation of SARS-CoV-2-specific mRNA, which is recognized by innate immune receptors, such as TLR3. This in…”
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Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by a RORγt inverse agonist by Whitehead, Gregory S, Kang, Hong Soon, Thomas, Seddon Y, Medvedev, Alexander, Karcz, Tadeusz P, Izumi, Gentaro, Nakano, Keiko, Makarov, Sergei S, Nakano, Hideki, Jetten, Anton M, Cook, Donald N

“…Airway neutrophilia occurs in approximately 50% of patients with asthma and is associated with particularly severe disease. Unfortunately, this form of asthma…”
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The P2Y purinoceptor, P2Y14R, promotes AHR in an animal model of asthma by Karcz, Tadeusz, Nakano, Hideki, Jacobson, Kenneth, Cook, Donald

“…Abstract The initiation and propagation of immune responses in the lung are mediated in part by so-called ‘alarmins’ that include nucleotides and…”
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Trisubstituted 1,3,5-Triazines as Histamine H[sub.4] Receptor Antagonists with Promising Activity In Vivo by Olejarz-Maciej, Agnieszka, Mogilski, Szczepan, Karcz, Tadeusz, Werner, Tobias, Kamińska, Katarzyna, Kupczyk, Jarosław, Honkisz-Orzechowska, Ewelina, Latacz, Gniewomir, Stark, Holger, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota

“…Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H[sub.4] receptor (H[sub.4]R) is a promising target for the…”
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Endogenous UDP-Glc acts through the purinergic receptor P2RY14 to exacerbate eosinophilia and airway hyperresponsiveness in a protease model of allergic asthma by Karcz, Tadeusz, Whitehead, Gregory, Nakano, Hideki, Jacobson, Kenneth A, Cook, Donald N

“…Abstract Human asthma represents a wide spectrum of pathologies that likely arise through distinct molecular pathways, and a major therapeutic goal is to…”
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