Search Results - "Karch, P."

Vaccine technologies: From whole organisms to rationally designed protein assemblies by Karch, Christopher P., Burkhard, Peter

“…[Display omitted] Vaccines have been the single most significant advancement in public health, preventing morbidity and mortality in millions of people…”
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A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus by Li, Jianping, Helal, Zeinab H, Karch, Christopher P, Mishra, Neha, Girshick, Theodore, Garmendia, Antonio, Burkhard, Peter, Khan, Mazhar I

“…Infectious bronchitis virus (IBV) affects poultry respiratory, renal and reproductive systems. Currently the efficacy of available live attenuated or killed…”
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Design and characterization of a self-assembling protein nanoparticle displaying HIV-1 Env V1V2 loop in a native-like trimeric conformation as vaccine antigen by Karch, Christopher P., Bai, Hongjun, Torres, Oscar B., Tucker, Courtney A., Michael, Nelson L., Matyas, Gary R., Rolland, Morgane, Burkhard, Peter, Beck, Zoltan

“…The RV144 HIV-1 clinical trial demonstrated modest vaccine efficacy and identified IgG antibodies against the Env V1V2 loop that inversely correlated with risk…”
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The use of a P. falciparum specific coiled-coil domain to construct a self-assembling protein nanoparticle vaccine to prevent malaria by Karch, Christopher P, Doll, Tais A P F, Paulillo, Sara M, Nebie, Issa, Lanar, David E, Corradin, Giampietro, Burkhard, Peter

“…The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development of a malaria…”
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The current and future role of nanovaccines in HIV-1 vaccine development by Karch, Christopher P, Matyas, Gary R

“…: An efficacious vaccine for HIV-1 has been sought for over 30 years to eliminate the virus from the human population. Many challenges have occurred in the…”
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The diversity of HIV-1 fights against vaccine efficacy: how self-assembling protein nanoparticle technology may fight back by Karch, Christopher P, Burkhard, Peter, Matyas, Gary R, Beck, Zoltan

“…An efficacious HIV-1 vaccine has remained an elusive target for almost 40 years. The sheer diversity of the virus is one of the major roadblocks for vaccine…”
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Self-Assembling Protein Nanoparticles: implications for HIV-1 vaccine development by Karch, Christopher P, Matyas, Gary R, Burkhard, Peter, Beck, Zoltan

“…SAPNs can be used in combination with a built-in adjuvant system (5,6), a traditional adjuvant (7,8) or a modern adjuvant system (9). [...]SAPN-based vaccines…”
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Self-assembling protein nanoparticles with built-in flagellin domains increases protective efficacy of a Plasmodium falciparum based vaccine by Kaba, Stephen A., Karch, Christopher P., Seth, Labdhi, Ferlez, Karen M.B., Storme, Casey K., Pesavento, Danielle M., Laughlin, Paige Y., Bergmann-Leitner, Elke S., Burkhard, Peter, Lanar, David E.

“…•Self-adjuvanting, self-assembling protein nanoparticle to prevent malaria is made.•Amounts of selected domains of flagellin per nanoparticle are…”
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Engineering and characterization of a novel Self Assembling Protein for Toxoplasma peptide vaccine in HLA-A11:01, HLA-A02:01 and HLA-B07:02 transgenic mice by El Bissati, Kamal, Zhou, Ying, Paulillo, Sara M., Raman, Senthil K., Karch, Christopher P., Reed, Steve, Estes, Ashley, Estes, Amber, Lykins, Joseph, Burkhard, Peter, McLeod, Rima

“…Fighting smart diseases requires smart vaccines. Novel ways to present protective immunogenic peptide epitopes to human immune systems are needed. Herein, we…”
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Self-assembling protein nanoparticles: a promising tool against lethal influenza? by Burkhard, Peter, Karch, Christopher P

“…Influenza has a high mutation rate and strains vary from year to year due to antigenic drift and shift, necessitating new annual vaccine formulations. Since…”
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Impact of the expression system on the immune responses to self-assembling protein nanoparticles (SAPNs) displaying HIV-1 V1V2 loop by Karch, Christopher P., Paquin-Proulx, Dominic, Eller, Michael A., Matyas, Gary R., Burkhard, Peter, Beck, Zoltan

“…The V1V2 loop of the Env protein is a major target for HIV-1 vaccine development because in multiple studies antibodies to this region correlated with…”
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Vaccination with self-adjuvanted protein nanoparticles provides protection against lethal influenza challenge by Karch, Christopher P, Li, Jianping, Kulangara, Caroline, Paulillo, Sara M, Raman, Senthil K, Emadi, Sharareh, Tan, Anmin, Helal, Zeinab H, Fan, Qing, Khan, Mazhar I, Burkhard, Peter

“…Abstract Current influenza vaccines should be improved by the addition of universal influenza vaccine antigens in order to protect against multiple virus…”
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The Recovery of Locomotory Activity following Exhaustive Exercise in Juvenile Rainbow Trout (Oncorhynchus mykiss) by Lee‐Jenkins, S. S. Y., Binder, T. R., Karch, A. P., McDonald, D. G.

“…This study investigated the recovery of locomotory activity in exhausted juvenile rainbow trout (Oncorhynchus mykiss, ∼6–10‐cm fork length) in response to two…”
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Protein nanovaccine confers robust immunity against Toxoplasma by El Bissati, Kamal, Zhou, Ying, Paulillo, Sara Maria, Raman, Senthil Kumar, Karch, Christopher P., Roberts, Craig W., Lanar, David E., Reed, Steve, Fox, Chris, Carter, Darrick, Alexander, Jeff, Sette, Alessandro, Sidney, John, Lorenzi, Hernan, Begeman, Ian J., Burkhard, Peter, McLeod, Rima

“…We designed and produced a self-assembling protein nanoparticle. This self-assembling protein nanoparticle contains five CD8 + HLA-A03-11 supertypes-restricted…”
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Interactive contour deformation of an object using Graph cut by Karch, P, Zolotová, I

“…This paper presents the possibility of deformation of the object contours using Graph cut method. The user interactively defines the contour of the object…”
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Interactive contour deformation of moving object using graph cut by Zolotova, I, Karch, P

“…This paper deals with tracking of object with assistance by interactive deformation contour using Graph cut method. The method is used for the segmentation of…”
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Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference by Castro Alvarez, Javier J, Revel, Maxime, Carrasco, Judit, Cléard, Fabienne, Pauli, Daniel, Hilgers, Valérie, Karch, François, Maeda, Robert K

“…Intergenic transcription is a common feature of eukaryotic genomes and performs important and diverse cellular functions. Here, we investigate the iab-8 ncRNA…”
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Diet and body weight loss in the rat during calorie restriction by Karch, P B, Beaton, J R

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Continuous sheet metal width measurement using image processing methods by Jelen, V., Karch, P.

“…This article has focused on the methods suitable for measuring sheet metal width in industry on image processing algorithms basis. Analysis methods in…”
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An experimental comparison of modern methods of segmentation by Karch, P., Zolotova, I.

“…This paper deals with experimental comparison of classical method of Graph cut segmentation with segmentation using Active contours. From methods of Active…”
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