Search Results - "Karbowniczek, Magdalena"

TP53 Codon 72 Polymorphism Impacts Macrophage Activation through Reactive Oxygen Species-Dependent Cell Signaling Alterations by Silwal, Ashok, Reese, Britney, Patel, Bhaumik, Li, Yan, Kolev, Martin V, La-Beck, Ninh M, Karbowniczek, Magdalena M, Markiewski, Maciej M

“…The role of the most common TP53 single-nucleotide polymorphism (SNP) at codon 72, which encodes for proline (P72) or arginine (R72), in the regulation of the…”
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The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1 by Markiewski, Maciej M, Vadrevu, Surya Kumari, Sharma, Sharad K, Chintala, Navin Kumar, Ghouse, Shanawaz, Cho, Jun-Hung, Fairlie, David P, Paterson, Yvonne, Astrinidis, Aristotelis, Karbowniczek, Magdalena

“…Relatively little is known about factors that initiate immunosuppression in tumors and act at the interface between tumor cells and host cells. In this…”
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Complementing Cancer Metastasis by Kochanek, Dawn M, Ghouse, Shanawaz M, Karbowniczek, Magdalena M, Markiewski, Maciej M

“…Complement is an effector of innate immunity and a bridge connecting innate immunity and subsequent adaptive immune responses. It is essential for protection…”
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Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent by Parkhitko, Andrey, Myachina, Faina, Morrison, Tasha A, Hindi, Khadijah M, Auricchio, Neil, Karbowniczek, Magdalena, Wu, J. Julia, Finkel, Toren, Kwiatkowski, David J, Yu, Jane J, Henske, Elizabeth Petri

“…Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney…”
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mTOR Is Activated in the Majority of Malignant Melanomas by Karbowniczek, Magdalena, Spittle, Cynthia S., Morrison, Tasha, Wu, Hong, Henske, Elizabeth P.

“…The objective of this study was to determine whether activation of the kinase mammalian target of rapamycin (mTOR) is associated with human melanoma. We found…”
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Activation of the mTOR signaling pathway in renal clear cell carcinoma by Robb, Victoria A, Karbowniczek, Magdalena, Klein-Szanto, Andres J, Henske, Elizabeth P

“…We determined the frequency of mTOR/p70S6 kinase signaling pathway activation in clear cell renal cell carcinoma. Phospho-S6 (Ser235/236) and phospho-mTOR…”
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The Role of Complement in Angiogenesis by Markiewski, Maciej M., Daugherity, Elizabeth, Reese, Britney, Karbowniczek, Magdalena

“…The link of the complement system to angiogenesis has remained circumstantial and speculative for several years. Perhaps the most clinically relevant example…”
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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53 by Lee, Chung-Han, Inoki, Ken, Karbowniczek, Magdalena, Petroulakis, Emmanuel, Sonenberg, Nahum, Henske, Elizabeth Petri, Guan, Kun-Liang

“…Miscoordination of growth and proliferation with the cellular stress response can lead to tumorigenesis. Mammalian target of rapamycin (mTOR), a central cell…”
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Estrogen Promotes the Survival and Pulmonary Metastasis of Tuberin-Null Cells by Yu, Jane J., Robb, Victoria A., Morrison, Tasha A., Ariazi, Eric A., Karbowniczek, Magdalena, Astrinidis, Aristotelis, Wang, Chunrong, Hernandez-Cuebas, Lisa, Seeholzer, Laura F., Nicolas, Emmanuelle, Hensley, Harvey, Jordan, V. Craig, Walker, Cheryl L., Henske, Elizabeth P., Cobb, Melanie H.

“…Lymphangioleiomyomatosis (LAM) is an often fatal disease primarily affecting young women in which tuberin (TSC2)-null cells metastasize to the lungs. The…”
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Notch transactivates Rheb to maintain the multipotency of TSC-null cells by Cho, Jun-Hung, Patel, Bhaumik, Bonala, Santosh, Manne, Sasikanth, Zhou, Yan, Vadrevu, Surya K., Patel, Jalpa, Peronaci, Marco, Ghouse, Shanawaz, Henske, Elizabeth P., Roegiers, Fabrice, Giannikou, Krinio, Kwiatkowski, David J., Mansouri, Hossein, Markiewski, Maciej M., White, Brandon, Karbowniczek, Magdalena

“…Differentiation abnormalities are a hallmark of tuberous sclerosis complex (TSC) manifestations; however, the genesis of these abnormalities remains unclear…”
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Rheb Inhibits C-Raf Activity and B-Raf/C-Raf Heterodimerization by Karbowniczek, Magdalena, Robertson, Gavin P., Henske, Elizabeth Petri

“…The Ras-Raf-MEK signaling cascade is critical for normal development and is activated in many forms of cancer. We have recently shown that B-Raf kinase…”
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The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development by Karbowniczek, Magdalena, Zitserman, Diana, Khabibullin, Damir, Hartman, Tiffiney, Yu, Jane, Morrison, Tasha, Nicolas, Emmanuelle, Squillace, Rachel, Roegiers, Fabrice, Henske, Elizabeth Petri

“…Mutations in either of the genes encoding the tuberous sclerosis complex (TSC), TSC1 and TSC2, result in a multisystem tumor disorder characterized by lesions…”
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The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis by Zitserman, Diana, Gupta, Sapna, Kruger, Warren D, Karbowniczek, Magdalena, Roegiers, Fabrice

“…In Drosophila, the pattern of adult pigmentation is initiated during late pupal stages by the production of catecholamines DOPA and dopamine, which are…”
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Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex by Astrinidis, Aristotelis, Li, Chenggang, Zhang, Erik Y, Zhao, Xueheng, Zhao, Shuyang, Guo, Minzhe, Olatoke, Tasnim, Mattam, Ushodaya, Huang, Rong, Zhang, Alan G, Pitstick, Lori, Kopras, Elizabeth J, Gupta, Nishant, Jandarov, Roman, Smith, Eric P, Fugate, Elizabeth, Lindquist, Diana, Markiewski, Maciej M, Karbowniczek, Magdalena, Wikenheiser-Brokamp, Kathryn A, Setchell, Kenneth D R, McCormack, Francis X, Xu, Yan, Yu, Jane J

“…Tuberous sclerosis complex (TSC) is characterized by multisystem, low-grade neoplasia involving the lung, kidneys, brain, and heart. Lymphangioleiomyomatosis…”
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Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent by Karbowniczek, Magdalena, Cash, Timothy, Cheung, Mitchell, Robertson, Gavin P, Astrinidis, Aristotelis, Henske, Elizabeth Petri

“…Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome with manifestations that can include seizures, mental retardation, autism, and tumors in…”
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The Role of Tuberin in Cellular Differentiation: Are B-Raf and MAPK Involved? by KARBOWNICZEK, MAGDALENA, HENSKE, ELIZABETH PETRI

“…: Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome whose manifestations can include seizures, mental retardation, autism, and tumors in the…”
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Abstract 141: Role of TP53 codon 72 polymorphism in macrophage polarization by Silwal, Ashok, Reese, Britney, Lodhi, Niraj, Magdalena, Karbowniczek, Maciej, Markiewski

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128 Finding optimal targets for complement-based cancer therapy by Modaresahmadi, Shadan, Silwal, Ashok, Kolev, Martin, Karbowniczek, Magdalena, Markiewski, Maciej

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Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs by Sharma, Sharad K, Chintala, Navin K, Vadrevu, Surya Kumari, Patel, Jalpa, Karbowniczek, Magdalena, Markiewski, Maciej M

“…In contrast to tumor-associated macrophages, myeloid-derived suppressor cells, or inflammatory monocytes, functions of tissue resident macrophages, including…”
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Therapeutic Targeting of Vasculature in the Premetastatic and Metastatic Niches Reduces Lung Metastasis by Ghouse, Shanawaz M, Vadrevu, Surya K, Manne, Sasikanth, Reese, Britney, Patel, Jalpa, Patel, Bhaumik, Silwal, Ashok, Lodhi, Niraj, Paterson, Yvonne, Srivastava, Sanjay K, Karbowniczek, Magdalena, Markiewski, Maciej M

“…In the metastasis-targeted organs, angiogenesis is essential for the progression of dormant micrometastases to rapidly growing and clinically overt lesions…”
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