Protein Expression of bax, bcl‐2, and p53 in Patients with Non‐Hodgkin's Gastric Lymphoma: Prognostic Significance

Protein Expression of bax, bcl‐2, and p53 in Patients with Non‐Hodgkin's Gastric Lymphoma: Prognostic Significance

. The biologic significance of bcl‐2, bax, and p53 gene expression in patients with non‐Hodgkin's gastric lymphoma is unknown. We examined the prognostic value of these genes in 36 patients with gastric lymphoma treated in our clinic between 1990 and 1995. Paraffin‐embedded specimens from 36 pa...

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Bibliographic Details
Published in:World journal of surgery Vol. 24; no. 5; pp. 608 - 614
Main Authors: Charalambous, George K., Gomatos, Ilias P., Konstadoulakis, Manoussos M., Messaris, Evangelos G., Manouras, Andreas J., Apostolou, Anastasia E., Leandros, Emmanuel A., Karayannis, Maria K., Androulakis, George A.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer‐Verlag 01-05-2000
Springer
Springer Nature B.V
Subjects:
Adult
Aged
Aged, 80 and over
bcl-2-Associated X Protein
Biological and medical sciences
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Lymphoma, Non-Hodgkin - metabolism
Lymphoma, Non-Hodgkin - mortality
Male
Medical sciences
Middle Aged
Prognosis
Proto-Oncogene Proteins - biosynthesis
Proto-Oncogene Proteins c-bcl-2 - biosynthesis
Retrospective Studies
Stomach Neoplasms - metabolism
Stomach Neoplasms - mortality
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Tumor Suppressor Protein p53 - biosynthesis
Tumors
Human
Immunohistochemistry
Stomach
Prognosis
Malignant hemopathy
Gastrectomy
Non Hodgkin lymphoma
Survival
Retrospective
Pathology
TP53 Gene
Surgery
Lymphoproliferative syndrome
Digestive diseases
Predictive factor
Gastric disease
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Summary:. The biologic significance of bcl‐2, bax, and p53 gene expression in patients with non‐Hodgkin's gastric lymphoma is unknown. We examined the prognostic value of these genes in 36 patients with gastric lymphoma treated in our clinic between 1990 and 1995. Paraffin‐embedded specimens from 36 patients who underwent primary resection of the stomach for gastric lymphoma were analyzed immunohistochemically for p53, bax, and bcl‐2 gene expression. Expression of bax was seen in 24 of 36 patients (66.7%), p53 expression was found in 8 of 36 tumors (22.2%), and bcl‐2 cytoplasmic staining was detected in 6 of 36 patients (16.7%). We performed a univariate analysis to examine the possible correlation between the expression of these genes and the survival of our patients. Expression of bax protein proved to be a statistically significant prognostic factor (p= 0.049). Protein expression of p53 and bcl‐2 did not statistically correlate with survival. In the bcl‐2‐negative (−) patient group (30 patients), those who were bax‐positive had a statistically significant better survival than those who were bax‐negative (63.3% vs. 36.7%, p= 0.03). There was also a statistically significant correlation between p53 expression and the grade of the tumor (p= 0.0014). P53 protein expression increased along with the grade. Expression of bax is a significant prognostic factor in patients with gastric lymphoma. Its prognostic value increases significantly when studied in bcl‐2‐negative patients; but expression of bax failed to be an independent prognostic factor. Expression of bcl‐2 and p53 has no prognostic significance. Expression of p53 seems to represent a marker for loss of differentiation.
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ISSN:0364-2313
1432-2323
DOI:10.1007/s002689910098