Search Results - "Karatas, Hacer"

High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction by Karatas, Hacer, Townsend, Elizabeth C, Cao, Fang, Chen, Yong, Bernard, Denzil, Liu, Liu, Lei, Ming, Dou, Yali, Wang, Shaomeng

“…Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase, and targeting the MLL1 enzymatic activity has been proposed as a novel…”
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Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia by Cao, Fang, Townsend, Elizabeth C., Karatas, Hacer, Xu, Jing, Li, Li, Lee, Shirley, Liu, Liu, Chen, Yong, Ouillette, Peter, Zhu, Jidong, Hess, Jay L., Atadja, Peter, Lei, Ming, Qin, Zhaohui S., Malek, Sami, Wang, Shaomeng, Dou, Yali

“…Here we report a comprehensive characterization of our recently developed inhibitor MM-401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is…”
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Synthesis and Anticancer Activity of Novel Indole Derivatives as Dual EGFR/SRC Kinase Inhibitors by Olgen, Sureyya, Kaleli, Sevde Nur Biltekin, Karaca, Banu Taktak, Demirel, Ural U, Bristow, Hacer Karatas

“…Recent studies showed that the cooperation between c-SRC and EGFR is responsible for more aggressive phenotype in diverse tumors, including glioblastomas and…”
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TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics by Kunig, Verena B. K., Potowski, Marco, Akbarzadeh, Mohammad, Klika Škopić, Mateja, Santos Smith, Denise, Arendt, Lukas, Dormuth, Ina, Adihou, Hélène, Andlovic, Blaž, Karatas, Hacer, Shaabani, Shabnam, Zarganes‐Tzitzikas, Tryfon, Neochoritis, Constantinos G., Zhang, Ran, Groves, Matthew, Guéret, Stéphanie M., Ottmann, Christian, Rahnenführer, Jörg, Fried, Roland, Dömling, Alexander, Brunschweiger, Andreas

“…DNA‐encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of…”
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Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction by Karatas, Hacer, Li, Yangbing, Liu, Liu, Ji, Jiao, Lee, Shirley, Chen, Yong, Yang, Jiuling, Huang, Liyue, Bernard, Denzil, Xu, Jing, Townsend, Elizabeth C, Cao, Fang, Ran, Xu, Li, Xiaoqin, Wen, Bo, Sun, Duxin, Stuckey, Jeanne A, Lei, Ming, Dou, Yali, Wang, Shaomeng

“…We report herein the design, synthesis, and evaluation of macrocyclic peptidomimetics that bind to WD repeat domain 5 (WDR5) and block the WDR5–mixed lineage…”
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Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein–Protein Interaction by Zhou, Haibin, Liu, Liu, Huang, Jing, Bernard, Denzil, Karatas, Hacer, Navarro, Alexandro, Lei, Ming, Wang, Shaomeng

“…Menin is an essential oncogenic cofactor for mixed lineage leukemia 1 (MLL1)-mediated leukemogenesis through its direct interaction with MLL1. Targeting the…”
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A protein tertiary structure mimetic modulator of the Hippo signalling pathway by Adihou, Hélène, Gopalakrishnan, Ranganath, Förster, Tim, Guéret, Stéphanie M., Gasper, Raphael, Geschwindner, Stefan, Carrillo García, Carmen, Karatas, Hacer, Pobbati, Ajaybabu V., Vazquez‐Chantada, Mercedes, Davey, Paul, Wassvik, Carola M., Pang, Jeremy Kah Sheng, Soh, Boon Seng, Hong, Wanjin, Chiarparin, Elisabetta, Schade, Dennis, Plowright, Alleyn T., Valeur, Eric, Lemurell, Malin, Grossmann, Tom N., Waldmann, Herbert

“…Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated via a complex network of…”
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An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19 by Karatas, Hacer, Hanashalshahaby, Essam Hamied Ahmed, Catal, Unal, Butun, Yasar Enes, Kurt, Elif, Gursel, Sahin, Kaya, Adil, Guzel, Mustafa

“…Favipiravir is a wide-spectrum antiviral generic drug that has received large attention during the recent COVID-19 pandemic. While there are synthetic…”
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MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program by Xu, Jing, Li, Li, Xiong, Jie, denDekker, Aaron, Ye, Andrew, Karatas, Hacer, Liu, Liu, Wang, He, Qin, Zhaohui S, Wang, Shaomeng, Dou, Yali

“…Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia ( MLLr ) and is a validated therapeutic target. However, its role…”
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Synthesis and Potent Antimicrobial Activity of Some Novel 4-(5, 6-Dichloro-1H-benzimidazol-2-yl)-N-substituted Benzamides by Ozden, Seçkin, Karataş, Hacer, Yildiz, Sulhiye, Göker, Hakan

“…A series of 4‐(5, 6‐dichloro‐1H‐benzimidazol‐2‐yl)‐N‐substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against…”
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In Vivo Molecular Bioluminescence Imaging: New Tools and Applications by Mezzanotte, Laura, van ‘t Root, Moniek, Karatas, Hacer, Goun, Elena A, Löwik, Clemens W.G.M

“…in vivo bioluminescence imaging (BLi) is an optical molecular imaging technique used to visualize molecular and cellular processes in health and diseases and…”
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Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming by Guo, Yijing, Lei, Ienglam, Tian, Shuo, Gao, Wenbin, Hacer, Karatas, Li, Yangbing, Wang, Shaomeng, Liu, Liu, Wang, Zhong

“…Reprogramming of fibroblasts into induced cardiomyocytes (iCMs) is a potentially promising strategy for regenerating a damaged heart. However, low…”
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Synthesis and Potent In vitro Activity of Novel 1H-Benzimidazoles as Anti-MRSA Agents by Karataş, Hacer, Alp, Mehmet, Yıldız, Sulhiye, Göker, Hakan

“…A new class of 1H‐benzimidazolecarboxamidines was synthesized and evaluated for in vitro antibacterial and antifungal activities, including drug‐resistant…”
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Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket by Karatas, Hacer, Akbarzadeh, Mohammad, Adihou, Hélène, Hahne, Gernot, Pobbati, Ajaybabu V, Yihui Ng, Elizabeth, Guéret, Stéphanie M, Sievers, Sonja, Pahl, Axel, Metz, Malte, Zinken, Sarah, Dötsch, Lara, Nowak, Christine, Thavam, Sasikala, Friese, Alexandra, Kang, CongBao, Hong, Wanjin, Waldmann, Herbert

“…Transcriptional enhanced associate domain (TEAD) transcription factors together with coactivators and corepressors modulate the expression of genes that…”
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The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis by Laraia, Luca, Friese, Alexandra, Corkery, Dale P., Konstantinidis, Georgios, Erwin, Nelli, Hofer, Walter, Karatas, Hacer, Klewer, Laura, Brockmeyer, Andreas, Metz, Malte, Schölermann, Beate, Dwivedi, Mridula, Li, Lei, Rios-Munoz, Pablo, Köhn, Maja, Winter, Roland, Vetter, Ingrid R., Ziegler, Slava, Janning, Petra, Wu, Yao-Wen, Waldmann, Herbert

“…Autophagy mediates the degradation of damaged proteins, organelles and pathogens, and plays a key role in health and disease. Thus, the identification of new…”
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Identification of Quinolinols as Activators of TEAD-Dependent Transcription by Pobbati, Ajaybabu V, Mejuch, Tom, Chakraborty, Sayan, Karatas, Hacer, Bharath, Sakshibeedu R, Guéret, Stéphanie M, Goy, Pierre-Alexis, Hahne, Gernot, Pahl, Axel, Sievers, Sonja, Guccione, Ernesto, Song, Haiwei, Waldmann, Herbert, Hong, Wanjin

“…The transcriptional co-regulators YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are the vertebrate downstream…”
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Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1−WDR5 Interaction by Karatas, Hacer, Townsend, Elizabeth C, Bernard, Denzil, Dou, Yali, Wang, Shaomeng

“…MLL1 is a histone 3 lysine 4 (H3K4) methyltransferase and a promising new cancer therapeutic target. The catalytic activity of MLL1 is regulated by the…”
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MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency by Zhang, Hui, Gayen, Srimonta, Xiong, Jie, Zhou, Bo, Shanmugam, Avinash K., Sun, Yuqing, Karatas, Hacer, Liu, Liu, Rao, Rajesh C., Wang, Shaomeng, Nesvizhskii, Alexey I., Kalantry, Sundeep, Dou, Yali

“…The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it is unclear whether intrinsic…”
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The Pseudo‐Natural Product Rhonin Targets RHOGDI by Akbarzadeh, Mohammad, Flegel, Jana, Patil, Sumersing, Shang, Erchang, Narayan, Rishikesh, Buchholzer, Marcel, Kazemein Jasemi, Neda S., Grigalunas, Michael, Krzyzanowski, Adrian, Abegg, Daniel, Shuster, Anton, Potowski, Marco, Karatas, Hacer, Karageorgis, George, Mosaddeghzadeh, Niloufar, Zischinsky, Mia‐Lisa, Merten, Christian, Golz, Christopher, Brieger, Lucas, Strohmann, Carsten, Antonchick, Andrey P., Janning, Petra, Adibekian, Alexander, Goody, Roger S., Ahmadian, Mohammad Reza, Ziegler, Slava, Waldmann, Herbert

“…For the discovery of novel chemical matter generally endowed with bioactivity, strategies may be particularly efficient that combine previous insight about…”
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Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo by Karatas, Hacer, Maric, Tamara, D’Alessandro, Pier Luca, Yevtodiyenko, Aleksey, Vorherr, Thomas, Hollingworth, Gregory J, Goun, Elena A

“…Peptides constitute an important class of drugs for the treatment of multiple metabolic, oncological, and neurodegenerative diseases, and several hundred novel…”
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