A Formal Total Synthesis of (-)-Oudemansin B

A Formal Total Synthesis of (-)-Oudemansin B

(-)-Oudemansin B (1) was formally synthesized from the (2S, 3R)-3-hydroxy lactone 5 obtained by microbial asymmetric reduction as a key step.

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Bibliographic Details
Published in:Chemical & pharmaceutical bulletin Vol. 40; no. 10; pp. 2847 - 2848
Main Authors: AKITA, Hiroyuki, MATSUKURA, Hiroko, Karashima, Hirotoshi, OISHI, Takeshi
Format: Journal Article
Language:English
Published: Tokyo The Pharmaceutical Society of Japan 1992
Maruzen
Subjects:
(-)-oudemansin B
Aliphatic compounds
antibiotic
Chemistry
Exact sciences and technology
hydroxy γ-lactone
microbial reduction
Organic chemistry
Preparations and properties
total synthesis
Wittig reaction
Wittig reaction
Antibiotic
Diol
Aliphatic compound
Dienic compound
Ring cleavage
Total synthesis
Enantiomer(-)
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Description
Summary:(-)-Oudemansin B (1) was formally synthesized from the (2S, 3R)-3-hydroxy lactone 5 obtained by microbial asymmetric reduction as a key step.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.40.2847