Search Results - "Karasarides, Maria"

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate by Hübner, Anette, Mulholland, David J, Standen, Claire L, Karasarides, Maria, Cavanagh-Kyros, Julie, Barrett, Tamera, Chi, Hongbo, Greiner, Dale L, Tournier, Cathy, Sawyers, Charles L, Flavell, Richard A, Wu, Hong, Davis, Roger J

“…The c-Jun NH ₂-terminal kinase (JNK) signal transduction pathway is implicated in cancer, but the role of JNK in tumorigenesis is poorly understood. Here, we…”
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The RAF proteins take centre stage by Marais, Richard, Wellbrock, Claudia, Karasarides, Maria

“…Since their discovery over 20 years ago, the RAF proteins have been intensely studied. For most of that time, the focus of the field has been the C-RAF isoform…”
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A Direct Interaction between Oncogenic Ha-Ras and Phosphatidylinositol 3-Kinase Is Not Required for Ha-Ras-dependent Transformation of Epithelial Cells by Karasarides, Maria, Anand-Apte, Bela, Wolfman, Alan

“…Cells expressing oncogenic Ras proteins transmit a complex set of signals that ultimately result in constitutive activation of signaling molecules, culminating…”
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Phase 1b dose-escalation and cohort-expansion study of the safety, tolerability, and efficacy of a novel transforming growth factor-β receptor I kinase inhibitor (galunisertib [G]) administered in combination with the anti-PD-L1 antibody (durvalumab [D]) in recurrent or refractory metastatic pancreatic cancer by Melisi, Davide, Guba, Susan C., Karasarides, Maria, Andre, Valerie

“…Abstract only TPS501 Background: Transforming growth factor-β (TGF-β) can suppress adaptive and innate anti-tumor immune responses. G (LY2157299) is an oral…”
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High Interobserver Variability Among Pathologists Using Combined Positive Score to Evaluate PD-L1 Expression in Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma by Robert, Marie E., Rüschoff, Josef, Jasani, Bharat, Graham, Rondell P., Badve, Sunil S., Rodriguez-Justo, Manuel, Kodach, Liudmila L., Srivastava, Amitabh, Wang, Hanlin L., Tang, Laura H., Troncone, Giancarlo, Rojo, Federico, Van Treeck, Benjamin J., Pratt, James, Shnitsar, Iryna, Kumar, George, Karasarides, Maria, Anders, Robert A.

“…Reliable, reproducible methods to interpret programmed death ligand-1 (PD-L1) expression on tumor cells (TC) and immune cells (IC) are needed for pathologists…”
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Hallmarks of Resistance to Immune-Checkpoint Inhibitors by Karasarides, Maria, Cogdill, Alexandria P, Robbins, Paul B, Bowden, Michaela, Burton, Elizabeth M, Butterfield, Lisa H, Cesano, Alessandra, Hammer, Christian, Haymaker, Cara L, Horak, Christine E, McGee, Heather M, Monette, Anne, Rudqvist, Nils-Petter, Spencer, Christine N, Sweis, Randy F, Vincent, Benjamin G, Wennerberg, Erik, Yuan, Jianda, Zappasodi, Roberta, Lucey, Vanessa M Hubbard, Wells, Daniel K, LaVallee, Theresa

“…Immune-checkpoint inhibitors (ICI), although revolutionary in improving long-term survival outcomes, are mostly effective in patients with immune-responsive…”
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Scoring PD-L1 Expression in Urothelial Carcinoma: An International Multi-Institutional Study on Comparison of Manual and Artificial Intelligence Measurement Model (AIM-PD-L1) Pathology Assessments by Rüschoff, Josef, Kumar, George, Badve, Sunil, Jasani, Bharat, Krause, Emma, Rioux-Leclercq, Nathalie, Rojo, Federico, Martini, Maurizio, Cheng, Liang, Tretiakova, Maria, Mitchell, Catherine, Anders, Robert A., Robert, Marie E., Fahy, Darren, Pyle, Mike, Le, Quang, Yu, Limin, Glass, Benjamin, Baxi, Vipul, Babadjanova, Zulfia, Pratt, James, Brutus, Sergine, Karasarides, Maria, Hartmann, Arndt

“…Assessing programmed death ligand 1 (PD-L1) expression on tumor cells (TCs) using Food and Drug Administration-approved, validated immunoassays can guide the…”
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Tumor necrosis factor-α blocks apoptosis in melanoma cells when BRAF signaling is inhibited by GRAY-SCHOPFER, Vanessa C, KARASARIDES, Maria, HAYWARD, Robert, MARAIS, Richard

“…The protein kinase BRAF, a component of the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling…”
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ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis by Mavria, Georgia, Vercoulen, Yvonne, Yeo, Maggie, Paterson, Hugh, Karasarides, Maria, Marais, Richard, Bird, Demelza, Marshall, Christopher J.

“…Inhibition of ERK-MAPK signaling by expression of dominant-negative MEK1 in the tumor vasculature suppresses angiogenesis and tumor growth. In an organotypic…”
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Erratum to High Interobserver Variability Among Pathologists Using Combined Positive Score to Evaluate PD-L1 Expression in Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma [Modern Pathology 36(5) (2023) 100154] by Robert, Marie E., Rüschoff, Josef, Jasani, Bharat, Graham, Rondell P., Badve, Sunil S., Rodriguez-Justo, Manuel, Kodach, Liudmila L., Srivastava, Amitabh, Wang, Hanlin L., Tang, Laura H., Troncone, Giancarlo, Rojo, Federico, Van Treeck, Benjamin J., Pratt, James, Shnitsar, Iryna, Kumar, George, Karasarides, Maria, Anders, Robert A.

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Safety and Preliminary Clinical Activity of REGN5458, an Anti-Bcma x Anti-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma by Cooper, Dennis, Madduri, Deepu, Lentzsch, Suzanne, Jagannath, Sundar, Li, Jingjin, Boyapati, Anita, Adriaens, Lieve, Chokshi, Dhruti, Zhu, Min, Lowy, Israel, Weinreich, David M., Yancopoulos, George D., Sharma, Manish, Karasarides, Maria, Sternberg, David

“…Background Multiple myeloma (MM), the second most common hematologic malignancy, is characterized by the expansion of malignant plasma cells which express, the…”
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A multi-cohort phase 1 study of ramucirumab plus durvalumab: Preliminary safety and clinical activity in patients with locally advanced and unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma by Golan, Talia, Lin, Chia-Chi, Fu, Siqing, Wasserstrom, Heather, Mi, Gu, Laing, Naomi, Karasarides, Maria, Bang, Yung-Jue

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A study of REGN3767, an anti-LAG-3 antibody, alone and in combination with cemiplimab (REGN2810), an anti-PD1 antibody in advanced cancers by Papadopoulos, Kyriakos P., Lakhani, Nehal, Johnson, Melissa Lynne, Park, Haeseong, Wang, Ding, Yap, Timothy A., Moore, Kathleen N., Sims, Tasha Nicholle, Emeremni, Chetachi A., Karasarides, Maria, Kroog, Glenn S.

“…Abstract only TPS41 Background: Lymphocyte activation gene 3 (LAG-3) is an immune checkpoint receptor with a biological role in T-cell regulation. Analysis of…”
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B-RAF is a therapeutic target in melanoma by KARASARIDES, Maria, CHILOECHES, Antonio, SPRINGER, Caroline J, MARAIS, Richard, HAYWARD, Robert, NICULESCU-DUVAZ, Dan, SCANLON, Ian, FRIEDLOS, Frank, OGILVIE, Lesley, HEDLEY, Douglas, MARTIN, Jan, MARSHALL, Christopher J

“…B-RAF is a serine/threonine-specific protein kinase that is mutated in approximately 70% of human melanomas. However, the role of this signalling molecule in…”
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JNK2 Is a Positive Regulator of the cJun Transcription Factor by Jaeschke, Anja, Karasarides, Maria, Ventura, Juan-Jose, Ehrhardt, Anka, Zhang, Chao, Flavell, Richard A., Shokat, Kevan M., Davis, Roger J.

“…The cJun NH2-terminal kinase (JNK) signal transduction pathway is established to be an important mechanism of regulation of the cJun transcription factor…”
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A study of REGN3767, an anti-LAG-3 antibody, alone and in combination with cemiplimab (REGN2810), an anti-PD1 antibody, in advanced cancers by Papadopoulos, Kyriakos P., Lakhani, Nehal J., Johnson, Melissa Lynne, Park, Haeseong, Wang, Ding, Yap, Timothy Anthony, Moore, Kathleen N., Sims, Tasha Nicholle, Emeremni, Chetachi, Karasarides, Maria, Kroog, Glenn Scott

“…Abstract only…”
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First-in-human study of REGN3767 (R3767), a human LAG-3 monoclonal antibody (mAb), ± cemiplimab in patients (pts) with advanced malignancies by Papadopoulos, Kyriakos P., Lakhani, Nehal J., Johnson, Melissa Lynne, Park, Haeseong, Wang, Ding, Yap, Timothy A, Dowlati, Afshin, Maki, Robert G., Lynce, Filipa, Ulahannan, Susanna Varkey, Kelly, Karen, Sims, Tasha Nicholle, Bredlau, Amy-Lee, Bramble, Derrick, Gonzalez Ortiz, Ana, Zhu, Min, Chen, Huanyu, Karasarides, Maria, Kroog, Glenn

“…Abstract only 2508 Background: We present initial safety, pharmacokinetics (PK), and efficacy from the dose escalation study of R3767, alone (mono) or in…”
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V599EB-RAF is an oncogene in melanocytes by WELLBROCK, Claudia, OGILVIE, Lesley, HEDLEY, Douglas, KARASARIDES, Maria, MARTIN, Jan, NICULESCU-DUVAZ, Dan, SPRINGER, Caroline J, MARAIS, Richard

“…The oncogenic version of B-RAF, (V599E)B-RAF, is found in approximately 70% of human melanomas. However, the role that this oncogene plays in melanoma is…”
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Biological consequences of a direct interaction between Ha -Ras and PI 3-kinase by Karasarides, Maria

“…The Ras family of small GTPases regulate cellular processes by transmitting extracellular signals from growth factor receptors to the nucleus, ultimately…”
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