Search Results - "Karas, A."

The Chemical Synthesis of Insulin: An Enduring Challenge by Karas, John A, Wade, John D, Hossain, Mohammed Akhter

“…The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential for glycemic control and is used as a therapeutic for the…”
Get full text

Assessment of wound healing activity in diabetic mice treated with a novel therapeutic combination of selenium nanoparticles and platelets rich plasma by Karas, Rania A., Alexeree, Shaimaa, Elsayed, Hassan, Attia, Yasser A.

“…Diabetic wound healing is sluggish, often ending in amputations. This study tested a novel, two-punch therapy in mice—Selenium nanoparticles (Se NPs) and…”
Get full text

An Analysis Of The Carbon Footprint In Maritime Transport: Challenges And Opportunities For Reducing Greenhouse Gas Emissions by Karas, Adrianna

Get full text

Total Chemical Synthesis of a Nonfibrillating Human Glycoinsulin by Hossain, Mohammed Akhter, Okamoto, Ryo, Karas, John A, Praveen, Praveen, Liu, Mengjie, Forbes, Briony E, Wade, John D, Kajihara, Yasuhiro

“…Glycosylation is an accepted strategy to improve the therapeutic value of peptide and protein drugs. Insulin and its analogues are life-saving drugs for all…”
Get full text

Smart Port as a Key to the Future Development of Modern Ports by Karas, Adrianna

“…Technological innovations gives the opportunity to create so-called Smart Ports. However, determining which technologies to choose, how to implement them…”
Get full text

Systemic Illiquidity Noise-based measure: A solution for systemic liquidity monitoring in frontier and emerging markets by Dziwok, Ewa, Kara's, Marta A

“…The paper presents an alternative approach to measuring systemic illiquidity applicable to countries with frontier and emerging financial markets, where other…”
Get full text

Risk of complications and mortality following recurrent and non-recurrent Clostridioides difficile infection: a retrospective observational database study in England by Enoch, D.A., Murray-Thomas, T., Adomakoh, N., Dedman, D., Georgopali, A., Francis, N.A., Karas, A.

“…Clostridioides difficile infection (CDI) increases the risk of complications and mortality. We assessed the magnitude of these outcomes in a large cohort of…”
Get full text

The Antimicrobial Activity of Cannabinoids by Karas, John A., Wong, Labell J. M., Paulin, Olivia K. A., Mazeh, Amna C., Hussein, Maytham H., Li, Jian, Velkov, Tony

“…A post-antibiotic world is fast becoming a reality, given the rapid emergence of pathogens that are resistant to current drugs. Therefore, there is an urgent…”
Get full text

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides by Patil, Nitin A., Tailhades, Julien, Karas, John A., Separovic, Frances, Wade, John D., Hossain, Mohammed Akhter

“…Heterodimeric peptides linked by disulfide bonds are attractive drug targets. However, their chemical assembly can be tedious, time‐consuming, and low…”
Get full text

Antidiabetic potential of Selenium nanoparticles and plasma-rich platelets in diabetic mice by Karas, Rania A., Alexeree, Shaimaa, Elzohery, Nora, Abdel-Hafez, Shams H., Attia, Yasser A.

“…Diabetes mellitus is a widespread endocrine disorder, which is categorized as the fourth leading cause of global mortality. Allopathic medicine has yet to…”
Get full text

Lab to Field Assessment of the Ecotoxicological Impact of Chlorpyrifos, Isoproturon, or Tebuconazole on the Diversity and Composition of the Soil Bacterial Community by Storck, Veronika, Nikolaki, Sofia, Perruchon, Chiara, Chabanis, Camille, Sacchi, Angela, Pertile, Giorgia, Baguelin, Céline, Karas, Panagiotis A, Spor, Aymé, Devers-Lamrani, Marion, Papadopoulou, Evangelia S, Sibourg, Olivier, Malandain, Cedric, Trevisan, Marco, Ferrari, Federico, Karpouzas, Dimitrios G, Tsiamis, George, Martin-Laurent, Fabrice

“…Pesticides are intentionally applied to agricultural fields for crop protection. They can harm non-target organisms such as soil microorganisms involved in…”
Get full text

Vineyard practices reduce the incidence of Aspergillus spp. and alter the composition of carposphere microbiome in grapes ( Vitis vinifera L.) by Testempasis, S I, Papazlatani, C V, Theocharis, S, Karas, P A, Koundouras, S, Karpouzas, D G, Karaoglanidis, G S

“…Going through the new transitioning era of the "European Green Deal," the search for alternative, non-chemical, disease control methods is essential. bunch rot…”
Get full text

2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin by Karas, John A., Scanlon, Denis B., Forbes, Briony E., Vetter, Irina, Lewis, Richard J., Gardiner, James, Separovic, Frances, Wade, John D., Hossain, Mohammed A.

“…Chemical synthesis of peptides can allow the option of sequential formation of multiple cysteines through exploitation of judiciously chosen regioselective…”
Get full text

A review of mortality due to Clostridium difficile infection by Karas, J.A, Enoch, D.A, Aliyu, S.H

“…Summary In this review we examine published literature to ascertain mortality in relation to Clostridium difficile infection (CDI) and the factors associated…”
Get full text

Efficacy of alternative fidaxomicin dosing regimens for treatment of simulated Clostridium difficile infection in an in vitro human gut model by Chilton, C H, Crowther, G S, Todhunter, S L, Ashwin, H, Longshaw, C M, Karas, A, Wilcox, M H

“…Fidaxomicin treatment reduces the risk of recurrent Clostridium difficile infection (CDI) compared with vancomycin. Extending duration of fidaxomicin therapy…”
Get full text

High-Resolution Regional Digital Elevation Models and Derived Products from MESSENGER MDIS Images by Manheim, Madeleine R., Henriksen, Megan R., Robinson, Mark S., Kerner, Hannah R., Karas, Bradley A., Becker, Kris J., Chojnacki, Matthew, Sutton, Sarah S., Blewett, David T.

“…The Mercury Dual Imaging System (MDIS) on the Mercury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft has provided global images…”
Get full text

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study by Hussein, Maytham, Karas, John A, Schneider-Futschik, Elena K, Chen, Fan, Swarbrick, James, Paulin, Olivia K A, Hoyer, Daniel, Baker, Mark, Zhu, Yan, Li, Jian, Velkov, Tony

“…Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first…”
Get full text

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation by Dastpeyman, Mohadeseh, Karas, John A, Amin, Azin, Turner, Bradley J, Shabanpoor, Fazel

“…Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically active agents, such as therapeutic…”
Get full text

Chemical Synthesis and Characterization of an Equinatoxin II(1-85) Analogue by Karas, John A, Sani, Marc-Antoine, Separovic, Frances

“…The chemical synthesis of an 85 residue analogue of the pore-forming protein, Equinatoxin II (EqtII), was achieved. Peptide precursors with over 40 residues…”
Get full text

Host Species Determines the Composition of the Prokaryotic Microbiota in Phlebotomus Sandflies by Papadopoulos, Christos, Karas, Panagiotis A., Vasileiadis, Sotirios, Ligda, Panagiota, Saratsis, Anastasios, Sotiraki, Smaragda, Karpouzas, Dimitrios G.

“…Phlebotomine sandflies are vectors of the humans’ and mammals’ parasite Leishmania spp. Although the role of gut microbiome in the biological cycle of insects…”
Get full text