Search Results - "Karaolis, David K R"

Bacterial c-di-GMP Is an Immunostimulatory Molecule by Karaolis, David K. R, Means, Terry K, Yang, De, Takahashi, Munehisa, Yoshimura, Teizo, Muraille, Eric, Philpott, Dana, Schroeder, John T, Hyodo, Mamoru, Hayakawa, Yoshihiro, Talbot, Brian G, Brouillette, Eric, Malouin, Francois

“…Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown that treatment with exogenous c-di-GMP inhibits Staphylococcus…”
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c-di-GMP (3′-5′-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interactions and Biofilm Formation by KARAOLIS, David K. R, RASHID, Mohammed H, CHYTHANYA, Rajanna, WENSHENG LUO, HYODO, Mamoru, HAYAKAWA, Yoshihiro

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Cyclic Di-GMP Stimulates Protective Innate Immunity in Bacterial Pneumonia by Karaolis, David K.R, Newstead, Michael W, Zeng, Xianying, Hyodo, Mamoru, Hayakawa, Yoshihiro, Bhan, Urvhashi, Liang, Hallie, Standiford, Theodore J

“…Innate immunity is the primary mechanism by which extracellular bacterial pathogens are effectively cleared from the lung. We have previously shown that cyclic…”
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c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection by Ogunniyi, Abiodun D, Paton, James C, Kirby, Alun C, McCullers, Jonathan A, Cook, Jan, Hyodo, Mamoru, Hayakawa, Yoshihiro, Karaolis, David K.R

“…Abstract Cyclic diguanylate (c-di-GMP) is a unique bacterial intracellular signaling molecule capable of stimulating enhanced protective innate immunity…”
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c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection by Hu, Dong-Liang, Narita, Kouji, Hyodo, Mamoru, Hayakawa, Yoshihiro, Nakane, Akio, Karaolis, David K.R

“…Abstract Cyclic diguanylate (c-di-GMP) is a novel immunomodulator and immune enhancer that triggers a protective host innate immune response. The protective…”
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3′,5′-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Staphylococcus aureus Strains in a Mouse Model of Mastitis Infection by BROUILLETTE, Eric, HYODO, Mamoru, HAYAKAWA, Yoshihiro, KARAOLIS, David K. R, MALOUIN, Francois

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A bacteriophage encoding a pathogenicity island, a type-IV pilus and a phage receptor in cholera bacteria by Karaolis, David K. R, Somara, Sita, Maneval, David R, Johnson, Judith A, Kaper, James B

“…The virulence properties of many pathogenic bacteria are due to proteins encoded by large gene clusters called pathogenicity islands, which are found in a…”
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High-Frequency Rugose Exopolysaccharide Production by Vibrio cholerae by ALI, Afsar, RASHID, Mohammed H, KARAOLIS, David K. R

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Extraction of Aerosol-Deposited Yersinia pestis from Indoor Surfaces To Determine Bacterial Environmental Decay by Gut, Ian M, Bartlett, Ryan A, Yeager, John J, Leroux, Brian, Ratnesar-Shumate, Shanna, Dabisch, Paul, Karaolis, David K R

“…Public health and decontamination decisions following an event that causes indoor contamination with a biological agent require knowledge of the environmental…”
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A Vibrio cholerae Pathogenicity Island Associated with Epidemic and Pandemic Strains by David K. R. Karaolis, Johnson, Judith A., Bailey, Camella C., Boedeker, Edgar C., Kaper, James B., Reeves, Peter R.

“…The bacterial species Vibrio cholerae includes harmless aquatic strains as well as strains capable of causing epidemics and global pandemics of cholera. While…”
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The Vibrio Pathogenicity Island-Encoded Mop Protein Modulates the Pathogenesis and Reactogenicity of Epidemic Vibrio cholerae by Zhang, Dalin, Xu, Zheng, Sun, Weiyun, Karaolis, David K R

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STING ligand c-di-GMP improves cancer vaccination against metastatic breast cancer by Chandra, Dinesh, Quispe-Tintaya, Wilber, Jahangir, Arthee, Asafu-Adjei, Denise, Ramos, Ilyssa, Sintim, Herman O, Zhou, Jie, Hayakawa, Yoshihiro, Karaolis, David K R, Gravekamp, Claudia

“…Cancer vaccination may be our best and most benign option for preventing or treating metastatic cancer. However, breakthroughs are hampered by immune…”
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Complete Genome Sequence of the Quality Control Strain Staphylococcus aureus subsp. aureus ATCC 25923 by Treangen, Todd J, Maybank, Rosslyn A, Enke, Sana, Friss, Mary Beth, Diviak, Lynn F, Karaolis, David K R, Koren, Sergey, Ondov, Brian, Phillippy, Adam M, Bergman, Nicholas H, Rosovitz, M J

“…Staphylococcus aureus subsp. aureus ATCC 25923 is commonly used as a control strain for susceptibility testing to antibiotics and as a quality control strain…”
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Prevalence of virulence-associated genes in clinical and environmental Vibrio cholerae strains isolated in Brazil between 1991 and 1999 by Vital Brazil, Juliana M, Alves, Ronaldo M, Rivera, Irma N.G, Rodrigues, Dália P, Karaolis, David K.R, Campos, Leila C

“…Abstract Genes located on the CTX element and the Vibrio cholerae pathogenicity island (VPI) were investigated in 297 clinical V. cholerae O1 and 76…”
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Transcriptional analysis and operon structure of the tagA–orf2–orf3–mop–tagD region on the Vibrio pathogenicity island in epidemic V. cholerae by Zhang, Dalin, Manos, Jim, Ma, Xinrong, Belas, Robert, Karaolis, David K.R.

“…Abstract The Vibrio pathogenicity island (VPI) in epidemic Vibrio cholerae is an essential virulence gene cluster. The VPI can excise from the chromosome and…”
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Identification of genes involved in the switch between the smooth and rugose phenotypes of Vibrio cholerae by Rashid, Mohammed H, Rajanna, Chythanya, Ali, Afsar, Karaolis, David K.R

“…Vibrio cholerae can switch to a ‘rugose’ phenotype characterized by an exopolysaccharide (EPS) matrix, wrinkled colony morphology, increased biofilm formation…”
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Comparison of Vibrio cholerae pathogenicity islands in sixth and seventh pandemic strains by KARAOLIS, David K. R, RUITING LAN, KAPER, James B, REEVES, Peter R

“…Epidemic Vibrio cholerae strains possess a large cluster of essential virulence genes on the chromosome called the Vibrio pathogenicity island (VPI). The VPI…”
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Role of exopolysaccharide, the rugose phenotype and VpsR in the pathogenesis of epidemic Vibrio cholerae by Rashid, Mohammed H, Rajanna, Chythanya, Zhang, Dalin, Pasquale, Vincenzo, Magder, Laurence S, Ali, Afsar, Dumontet, Stefano, Karaolis, David K.R

“…Vibrio cholerae, the causative agent of cholera can produce an exopolysaccharide (EPS). Some strains can also phenotypically switch from a smooth to a ‘rugose’…”
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Analysis of the Vibrio pathogenicity island-encoded Mop protein suggests a pleiotropic role in the virulence of epidemic Vibrio cholerae by Zhang, Dalin, Rajanna, Chythanya, Sun, Weiyun, Karaolis, David K.R.

“…Epidemic Vibrio cholerae contain a large essential virulence gene cluster called the Vibrio pathogenicity island (VPI). We recently reported that no in vitro…”
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3′,5′-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation by Karaolis, David K.R., Cheng, Kunrong, Lipsky, Michael, Elnabawi, Ahmed, Catalano, Jennifer, Hyodo, Mamoru, Hayakawa, Yoshihiro, Raufman, Jean-Pierre

“…The novel cyclic dinucleotide, 3′,5′-cyclic diguanylic acid, cGpGp (c-di-GMP), is a naturally occurring small molecule that regulates important signaling…”
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