Search Results - "Karandikar, Umesh C"

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology by Saxena, Kapil, Blutt, Sarah E, Ettayebi, Khalil, Zeng, Xi-Lei, Broughman, James R, Crawford, Sue E, Karandikar, Umesh C, Sastri, Narayan P, Conner, Margaret E, Opekun, Antone R, Graham, David Y, Qureshi, Waqar, Sherman, Vadim, Foulke-Abel, Jennifer, In, Julie, Kovbasnjuk, Olga, Zachos, Nicholas C, Donowitz, Mark, Estes, Mary K

“…Human gastrointestinal tract research is limited by the paucity of in vitro intestinal cell models that recapitulate the cellular diversity and complex…”
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Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections by Zou, Winnie Y, Blutt, Sarah E, Crawford, Sue E, Ettayebi, Khalil, Zeng, Xi-Lei, Saxena, Kapil, Ramani, Sasirekha, Karandikar, Umesh C, Zachos, Nicholas C, Estes, Mary K

“…Human rotavirus (HRV) and human norovirus (HuNoV) infections are recognized as the most common causes of epidemic and sporadic cases of gastroenteritis…”
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Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids by Murakami, Kosuke, Tenge, Victoria R., Karandikar, Umesh C., Lin, Shih-Ching, Ramani, Sasirekha, Ettayebi, Khalil, Crawford, Sue E., Zeng, Xi-Lei, Neill, Frederick H., Ayyar, B. Vijayalakshmi, Katayama, Kazuhiko, Graham, David Y., Bieberich, Erhard, Atmar, Robert L., Estes, Mary K.

“…Human noroviruses (HuNoVs) cause sporadic and epidemic outbreaks of gastroenteritis in all age groups worldwide. We previously reported that stem cell-derived…”
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Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids by Lin, Shih-Ching, Qu, Lin, Ettayebi, Khalil, Crawford, Sue E., Blutt, Sarah E., Robertson, Matthew J., Zeng, Xi-Lei, Tenge, Victoria R., Ayyar, B. Vijayalakshmi, Karandikar, Umesh C., Yu, Xiaomin, Coarfa, Cristian, Atmar, Robert L., Ramani, Sasirekha, Estes, Mary K.

“…Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis worldwide; yet currently, no vaccines or FDA-approved antiviral drugs are available…”
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A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection by Saxena, Kapil, Simon, Lukas M., Zeng, Xi-Lei, Blutt, Sarah E., Crawford, Sue E., Sastri, Narayan P., Karandikar, Umesh C., Ajami, Nadim J., Zachos, Nicholas C., Kovbasnjuk, Olga, Donowitz, Mark, Conner, Margaret E., Shaw, Chad A., Estes, Mary K.

“…The intestinal epithelium can limit enteric pathogens by producing antiviral cytokines, such as IFNs. Type I IFN (IFN-α/β) and type III IFN (IFN-λ) function at…”
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CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection by Ayyar, B. Vijayalakshmi, Ettayebi, Khalil, Salmen, Wilhelm, Karandikar, Umesh C., Neill, Frederick H., Tenge, Victoria R., Crawford, Sue E., Bieberich, Erhard, Prasad, B. V. Venkataram, Atmar, Robert L., Estes, Mary K.

“…Globally, most cases of gastroenteritis are caused by pandemic GII.4 human norovirus (HuNoV) strains with no approved therapies or vaccines available. The…”
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Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection by Haga, Kei, Ettayebi, Khalil, Tenge, Victoria R, Karandikar, Umesh C, Lewis, Miranda A, Lin, Shih-Ching, Neill, Frederick H, Ayyar, B Vijayalakshmi, Zeng, Xi-Lei, Larson, Göran, Ramani, Sasirekha, Atmar, Robert L, Estes, Mary K

“…Human noroviruses (HuNoVs) are the leading cause of nonbacterial gastroenteritis worldwide. Histo-blood group antigen (HBGA) expression is an important…”
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Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients by Karandikar, Umesh C, Crawford, Sue E, Ajami, Nadim J, Murakami, Kosuke, Kou, Baijun, Ettayebi, Khalil, Papanicolaou, Genovefa A, Jongwutiwes, Ubonvan, Perales, Miguel-Angel, Shia, Jinru, Mercer, David, Finegold, Milton J, Vinjé, Jan, Atmar, Robert L, Estes, Mary K

“…Human noroviruses (HuNoVs) can often cause chronic infections in solid organ and haematopoietic stem cell transplant (HSCT) patients. Based on…”
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A novel system to culture human intestinal organoids under physiological oxygen content to study microbial-host interaction by Fofanova, Tatiana Y, Karandikar, Umesh C, Auchtung, Jennifer M, Wilson, Reid L, Valentin, Antonio J, Britton, Robert A, Grande-Allen, K Jane, Estes, Mary K, Hoffman, Kristi, Ramani, Sashirekha, Stewart, Christopher J, Petrosino, Joseph F

“…Mechanistic investigation of host-microbe interactions in the human gut are hindered by difficulty of co-culturing microbes with intestinal epithelial cells…”
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Drosophila eyes absent is required for normal cone and pigment cell development by Karandikar, Umesh C, Jin, Meng, Jusiak, Barbara, Kwak, SuJin, Chen, Rui, Mardon, Graeme

“…In Drosophila, development of the compound eye is orchestrated by a network of highly conserved transcriptional regulators known as the retinal determination…”
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Regulation of Drosophila eye development by the transcription factor Sine oculis by Jusiak, Barbara, Karandikar, Umesh C, Kwak, Su-Jin, Wang, Feng, Wang, Hui, Chen, Rui, Mardon, Graeme

“…Homeodomain transcription factors of the Sine oculis (SIX) family direct multiple regulatory processes throughout the metazoans. Sine oculis (So) was first…”
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The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development by Anderson, Aimée E, Karandikar, Umesh C, Pepple, Kathryn L, Chen, Zhihong, Bergmann, Andreas, Mardon, Graeme

“…In vitro data suggest that the human RbAp46 and RbAp48 genes encode proteins involved in multiple chromatin remodeling complexes and are likely to play…”
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Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster by Jusiak, Barbara, Wang, Feng, Karandikar, Umesh C., Kwak, Su-Jin, Wang, Hui, Chen, Rui, Mardon, Graeme

“…The eye of the fruit fly Drosophila melanogaster provides a highly tractable genetic model system for the study of animal development, and many genes that…”
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Two- and Three-Dimensional Bioengineered Human Intestinal Tissue Models for Cryptosporidium by Cardenas, Daviel, Bhalchandra, Seema, Lamisere, Hymlaire, Chen, Ying, Zeng, Xi-Lei, Ramani, Sasirekha, Karandikar, Umesh C, Kaplan, David L, Estes, Mary K, Ward, Honorine D

“…Conventional cell cultures utilizing transformed or immortalized cell lines or primary human epithelial cells have played a fundamental role in furthering our…”
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Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia by Tapia, Rocio, Perez-Yepez, Eloy A., Carlino, Maximillian J., Karandikar, Umesh C., Kralicek, Sarah E., Estes, Mary K., Hecht, Gail A.

“…Sperm flagellar 1 (also called CLAMP) is a microtubule-associated protein that regulates microtubule dynamics and planar cell polarity in multi-ciliated cells…”
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Gastrointestinal microphysiological systems by Blutt, Sarah E, Broughman, James R, Zou, Winnie, Zeng, Xi-Lei, Karandikar, Umesh C, In, Julie, Zachos, Nicholas C, Kovbasnjuk, Olga, Donowitz, Mark, Estes, Mary K

“…Gastrointestinal diseases are a significant health care and economic burden. Prevention and treatment of these diseases have been limited by the available…”
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Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion by Chang-Graham, Alexandra L, Danhof, Heather A, Engevik, Melinda A, Tomaro-Duchesneau, Catherine, Karandikar, Umesh C, Estes, Mary K, Versalovic, James, Britton, Robert A, Hyser, Joseph M

“…Background & AimsEnteroendocrine cells (EECs) are specialized epithelial cells that produce molecules vital for intestinal homeostasis, but because of their…”
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Su1203 The Plasticity of the Intestinal Stem Cell Compartment and Its Induction Following Rotavirus Infection by Zou, Winnie Y, Blutt, Sarah, Zeng, Xi-Lei, Karandikar, Umesh C, Shroyer, Noah F, Donowitz, Mark, Estes, Mary

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34 Human Intestinal Epithelial Response to Gastrointestinal Virus Infection Using Enteroids by Blutt, Sarah E, Saxena, Kapil, Crawford, Sue E, Broughman, James R, Conner, Margaret E, Ettayebi, Khalil, Karandikar, Umesh C, Zeng, Xilei, In, Julie, Foulke-Abel, Jennifer, Zachos, Nicholas C, Kovbasnjuk, Olga, Donowitz, Mark, Estes, Mary K

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An activity-based two-hybrid system for the selective identification of substrates of protein kinases by Shaffer, Jonathan M., Karandikar, Umesh C., Bidwai, Ashok P.

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