Search Results - "Karandikar, Nitin"

IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes by Crawford, Michael P, Borcherding, Nicholas, Karandikar, Nitin J

“…CD4+ T-helper 17 (Th17) T cells are a key population in protective immunity during infection and in self-tolerance/autoimmunity. Through the secretion of…”
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Systematic Evaluation of Hematologic Parameters and Blood Smear Findings in Patients With SARS-CoV-2 vs Other Viral Respiratory Infections by Chopra, Saurav, Karandikar, Nitin J, Holman, Carol J

“…Abstract Objectives We evaluated and compared the peripheral blood findings in patients with acute COVID-19 vs other viral respiratory infections. Methods We…”
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CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression by Crawford, Michael P., Sinha, Sushmita, Renavikar, Pranav S., Borcherding, Nicholas, Karandikar, Nitin J.

“…Untoward effector CD4+ T cell responses are kept in check by immune regulatory mechanisms mediated by CD4+ and CD8+ T cells. CD4+ T helper 17 (Th17) cells,…”
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Disruption of IFNγ, GZMB, PRF1, or LYST Results in Reduced Suppressive Function in Human CD8+ T Cells by Vemulawada, Chakrapani, Renavikar, Pranav S, Crawford, Michael P, Steward-Tharp, Scott, Karandikar, Nitin J

“…An imbalance between proinflammatory and regulatory processes underlies autoimmune disease pathogenesis. We have shown that acute relapses of multiple…”
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Prevotella histicola , A Human Gut Commensal, Is as Potent as COPAXONE® in an Animal Model of Multiple Sclerosis by Shahi, Shailesh K, Freedman, Samantha N, Murra, Alexandra C, Zarei, Kasra, Sompallae, Ramakrishna, Gibson-Corley, Katherine N, Karandikar, Nitin J, Murray, Joseph A, Mangalam, Ashutosh K

“…Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. We and others have shown that there is enrichment or depletion of some gut…”
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Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours by Rakheja, Dinesh, Chen, Kenneth S., Liu, Yangjian, Shukla, Abhay A., Schmid, Vanessa, Chang, Tsung-Cheng, Khokhar, Shama, Wickiser, Jonathan E., Karandikar, Nitin J., Malter, James S., Mendell, Joshua T., Amatruda, James F.

“…Wilms tumour is the most common childhood kidney cancer. Here we report the whole-exome sequencing of 44 Wilms tumours, identifying missense mutations in the…”
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Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells by Sinha, Sushmita, Renavikar, Pranav S, Crawford, Michael P, Steward-Tharp, Scott M, Brate, Ashley, Tsalikian, Eva, Tansey, Michael, Shivapour, Ezzatollah T, Cho, Tracey, Kamholz, John, Karandikar, Nitin J

“…Factors regulating self-antigen directed immune-responses in autoimmunity are poorly understood. Signal regulatory protein gamma (SIRPγ) is a human T-cell…”
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The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination by Chen, Ying, Wu, Heng, Wang, Shuzong, Koito, Hisami, Li, Jianrong, Ye, Feng, Hoang, Jenny, Escobar, Sabine S, Gow, Alexander, Arnett, Heather A, Trapp, Bruce D, Karandikar, Nitin J, Hsieh, Jenny, Lu, Q Richard

“…Here, Chen et al . describe the role of the G protein–coupled receptor GPR17 in oligodendrocytes and show that it acts as a negative regulator of…”
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Proteolipid Protein-Induced Mouse Model of Multiple Sclerosis Requires B Cell-Mediated Antigen Presentation by Wilhelm, Connor R, Upadhye, Mohit A, Eschbacher, Kathryn L, Karandikar, Nitin J, Boyden, Alexander W

“…The pathogenic role B cells play in multiple sclerosis is underscored by the success of B cell depletion therapies. Yet, it remains unclear how B cells…”
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Immune regulation of multiple sclerosis by CD8+ T cells by Sinha, Sushmita, Itani, Farah R., Karandikar, Nitin J.

“…The role of CD8+ T cells in the process of autoimmune pathology has been both understudied and controversial. Multiple sclerosis (MS) is an inflammatory,…”
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Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein by Boyden, Alexander W., Brate, Ashley A., Karandikar, Nitin J.

“…Therapeutic success of B cell-targeting approaches in multiple sclerosis (MS) has intensified research into the pathogenic and regulatory roles these cells…”
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CD8(+) T Cells Are Required For Glatiramer Acetate Therapy in Autoimmune Demyelinating Disease by Tyler, Andrew F, Mendoza, Jason P, Firan, Mihail, Karandikar, Nitin J

“…The exact mechanism of glatiramer acetate (GA, Copaxone®), an FDA-approved immunomodulatory therapy for multiple sclerosis (MS), remains unclear after decades…”
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Immune Autoregulatory CD8 T Cells Require IFN-γ Responsiveness to Optimally Suppress Central Nervous System Autoimmunity by Boyden, Alexander W, Brate, Ashley A, Stephens, Laura M, Karandikar, Nitin J

“…Investigating the complex cellular interplay controlling immunopathogenic and immunoregulatory responses is critical for understanding multiple sclerosis (MS)…”
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Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis by Cummings, Matthew, Arumanayagam, Anitha Christy Sigamani, Zhao, Picheng, Kannanganat, Sunil, Stuve, Olaf, Karandikar, Nitin J, Eagar, Todd N

“…Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) where pathology is thought to be regulated by autoreactive…”
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Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function by Kashi, Venkatesh P, Ortega, Sterling B, Karandikar, Nitin J

“…Experimental autoimmune encephalomyelitis (EAE) is a well-established murine model of multiple sclerosis, an immune-mediated demyelinating disorder of the…”
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Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis by Shahi, Shailesh K, Jensen, Samantha N, Murra, Alexandra C, Tang, Na, Guo, Hui, Gibson-Corley, Katherine N, Zhang, Jian, Karandikar, Nitin J, Murray, Joseph A, Mangalam, Ashutosh K

“…Gut microbiota has emerged as an important environmental factor in the pathobiology of multiple sclerosis (MS), an inflammatory demyelinating disease of the…”
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The mechanism of action of glatiramer acetate treatment in multiple sclerosis by RACKE, Michael K, LOVETT-RACKE, Amy E, KARANDIKAR, Nitin J

“…Glatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple…”
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A Functionally Distinct CXCR3 + /IFN-γ + /IL-10 + Subset Defines Disease-Suppressive Myelin-Specific CD8 T Cells by Brate, Ashley A, Boyden, Alexander W, Jensen, Isaac J, Badovinac, Vladimir P, Karandikar, Nitin J

“…Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS. We have previously demonstrated that CNS-specific CD8 T cells possess a…”
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Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system by Shahi, Shailesh K., Freedman, Samantha N., Dahl, Rachel A., Karandikar, Nitin J., Mangalam, Ashutosh K.

“…Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS). Its corresponding animal model, experimental autoimmune…”
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Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage by Roa, Jorge A., Sarkar, Deepon, Zanaty, Mario, Ishii, Daizo, Lu, Yongjun, Karandikar, Nitin J., Hasan, David M., Ortega, Sterling B., Samaniego, Edgar A.

“…Cerebral vasospasm (VSP) is a common phenomenon after aneurysmal subarachnoid hemorrhage (aSAH) and contributes to neurocognitive decline. The natural history…”
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