Elective Pneumonectomy for Non-Small Cell Lung Cancer: Factors Affecting Early Operative Mortality and Morbidity

Background: The aim of this study was to investigate the factors influencing the morbidity and mortality of the non-small cell lung cancer (NSCLC) cases where pneumonectomy was performed. Material & methods: All 101 patients who had underwent a pneumonectomy for NSCLC between 1994-2001 in our ho...

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Published in:	Acta chirurgica belgica Vol. 106; no. 5; pp. 550 - 553
Main Authors:	Karamustafaoglu, Y.A., Haciibrahimoglu, G., Fazlioglu, M., Olcmen, A., Kutlu, C.A., Gurses, A., Bedirhan, M.A.
Format:	Journal Article
Language:	English
Published:	Bruxelles Taylor & Francis 2006 Acta medica Belgica
Subjects:	Adult Aged Biological and medical sciences Carcinoma, Small Cell - mortality Carcinoma, Small Cell - surgery Elective Surgical Procedures Female General aspects Humans Lung cancer Lung Neoplasms - mortality Lung Neoplasms - surgery Male Medical sciences Middle Aged non-small cell lung cancer Pneumology Pneumonectomy Postoperative Complications Tumors of the respiratory system and mediastinum non-small cell lung cancer Lung disease Respiratory disease Lung cancer Mortality pneumonectomy Malignant tumor non-small cell lung carcinoma Epidemiology Morbidity Medicine Treatment Surgery Bronchus disease Early Pneumectomy
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Summary:	Background: The aim of this study was to investigate the factors influencing the morbidity and mortality of the non-small cell lung cancer (NSCLC) cases where pneumonectomy was performed. Material & methods: All 101 patients who had underwent a pneumonectomy for NSCLC between 1994-2001 in our hospital were included in the retrospective study. There were 97 males and 4 females with a mean age of 56 ± 9.6. Factors affecting morbidity and mortality were analysed by univariate and multivariate analysis. Results: The morbidity rate was 53% and the mortality rate was 9%. Morbidity was related to cardiopulmonary complications in 40% of the cases. The risk factors for cardiopulmonary morbidity with univariate analysis were age > 60 years (p = 0.004), FEV1 < 2 lt (p = 0.016), early bronchopleural fistula (p = 0.0001), tumour size > 4 cm (p = 0.033), vital capacity < 3.7 lt (p = 0.016), forced vital capacity < 3.5 lt (p = 0.033). With multivariate analysis the risk factors cardiopulmonary morbidity were age (60 >) (p = 0.012) and tumour size > 4 cm (p = 0.043). The risk factors mortality with univariate analysis were right pneumonectomy (p = 0.025), respiratory morbidity (p = 0.0001), cardiac morbidity (p = 0.002), cell type (Epidermoid CA) (0.047), tumour size > 6 cm (p = 0.036), fluid infusion (p = 0.009), forced vital capacity < 78% (p = 0.039), forced expiratory volume in 1 second < 75% (p = 0.039), PO2 (p = 0.037), PCO2 > 42 mmHg (p = 0.023). Conclusion: Among the pneumonectomies performed for NSCLC, the causes of postoperative morbidity were multi-factorial, however, multivariate analysis did not show any significant factor affecting the mortality, related to this procedure.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-5458
DOI:	10.1080/00015458.2006.11679950