Uric acid blood levels and relationship with the components of metabolic syndrome in hypertensive patients

Associations between high serum uric acid (SUA) levels and high blood pressure (BP), as well as between SUA levels and metabolic syndrome (MetS) have already been reported. The aim of the study was to investigate the relationship between the components of MetS with the SUA levels as also between SUA...

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Published in:	Journal of human hypertension Vol. 30; no. 7; pp. 414 - 417
Main Authors:	Papavasileiou, M V, Karamanou, A G, Kalogeropoulos, P, Moustakas, G, Patsianis, S, Pittaras, A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-07-2016 Nature Publishing Group
Subjects:	692/499 Adult Aged Analysis Apolipoprotein A-I - blood Apolipoprotein B-100 - blood Apolipoproteins Biomarkers - blood Blood Glucose - metabolism Blood levels Blood Pressure Cholesterol, HDL - blood Diagnosis Epidemiology Female Health Administration High density lipoprotein Humans Hypertension Hypertension - complications Hypertension - diagnosis Hypertension - physiopathology Hyperuricemia - blood Hyperuricemia - complications Hyperuricemia - diagnosis Lipids - blood Male Medicine Medicine & Public Health Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - complications Metabolic Syndrome - diagnosis Metabolic Syndrome - physiopathology Metabolic syndrome X Middle Aged original-article Physiological aspects Population studies Public Health Risk Factors Statistical analysis Triglycerides Triglycerides - blood Up-Regulation Uric acid Uric Acid - blood Waist Circumference Greece
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Summary:	Associations between high serum uric acid (SUA) levels and high blood pressure (BP), as well as between SUA levels and metabolic syndrome (MetS) have already been reported. The aim of the study was to investigate the relationship between the components of MetS with the SUA levels as also between SUA and apolipoproteins A1 and B (apoA1 and apoB) ratio in hypertensive patients. A total of 2577 consecutive hypertensive patients (1193 male and 1384 female) aged 57.5±13.3 years, were enrolled in our research. Samples were taken to measure SUA, glucose, triglycerides, high density lipoprotein (HDL-C), components of the MetS and apoA1 and apoB. The study population was divided into two groups: group A: SUA levels above normal range (men ⩾7 mg dl −1 , women ⩾6 mg dl −1 ) and group B: SUA levels within normal range. In the overall study population, SUA levels showed a statistically significant correlation with waist circumference (WC; r =0.293, P <0.000), triglycerides ( r =0.197, P <0.000), glucose ( r =0.085, P <0.000), apoB/apoA1 ( r =0.136, P <0.000) and HDL-C ( r =−0.235, P <0,001). In newly diagnosed untreated hypertensive patients there was also a statistically significant correlation of SUA levels with WC ( r =0.331, P <0.001), triglycerides ( r =0.228, P <0.001) apoB/apoA1 ratio ( r =0.202, P <0.001) and HDL-C ( r =−0.278, P <0.001). In hyperurecemic hypertensives there was a statistically significant correlation between SUA levels with WC ( r =0.168, P =0.007), apoB/apoA1 ratio ( r =0.256, P =0.003) and HDL-C ( r =−0.202, P <0.001). SUA levels correlate significantly with all the components of MetS, as well as with the risk factor apoB/apoA1 ratio, in hypertensive patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0950-9240 1476-5527
DOI:	10.1038/jhh.2015.53