Does hormone therapy affect attention and memory in sleep-deprived women?

Does hormone therapy affect attention and memory in sleep-deprived women?

Objectives To evaluate whether hormone therapy (HT) modifies cognitive performance during sleep deprivation in postmenopausal women. Comparison was made with a group of young women. Methods Participants included 26 postmenopausal women (age 58-72 years, 16 HT users, 10 non-users), 11 young women (ag...

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Bibliographic Details
Published in:Climacteric : the journal of the International Menopause Society Vol. 11; no. 3; pp. 221 - 232
Main Authors: Alhola, P., Kylmälä, M., Sofia Urrila, A., Karakorpi, M., Portin, R., Kalleinen, N., Polo-Kantola, P.
Format: Journal Article
Language:English
Published: England Informa UK Ltd 2008
Taylor & Francis
Taylor & Francis Ltd
Subjects:
Adult
Aged
AGING
Attention - drug effects
COGNITION
Cognition & reasoning
Cognition Disorders - drug therapy
Female
HORMONE REPLACEMENT THERAPY
Humans
Memory
Memory - drug effects
Menopause
Middle Aged
POSTMENOPAUSE
Postmenopause - psychology
Reaction Time
SLEEP DEPRIVATION
Sleep Deprivation - physiopathology
Sleep Deprivation - psychology
WOMEN
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Summary:Objectives To evaluate whether hormone therapy (HT) modifies cognitive performance during sleep deprivation in postmenopausal women. Comparison was made with a group of young women. Methods Participants included 26 postmenopausal women (age 58-72 years, 16 HT users, 10 non-users), 11 young women (age 20-26 years). They spent four consecutive nights in the sleep laboratory. Cognitive tests of attention, working memory, and verbal episodic memory were carried out after the baseline night, 25-h sleep deprivation, and recovery night. Results Sleep deprivation impaired performance in all groups. It was manifested either as delayed practice effect or deteriorated performance (p < 0.05). In simple reaction time and 10-choice reaction time, non-users and young maintained their performance, whereas HT users suffered a minor impairment (p < 0.01). In other measurements, there was no interaction of group and condition. In 10-choice reaction time and vigilance, postmenopausal women made fewer errors and omissions than the young (p < 0.05). For most tasks, all groups showed improvement after one recovery night. Conclusions HT had a minor adverse effect on cognitive performance during sleep deprivation. Attention and memory deteriorated similarly in postmenopausal and young women, despite the lower initial performance level of postmenopausal women. One night of sleep ensured recovery in most tasks.
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ISSN:1369-7137
1473-0804
DOI:10.1080/13697130801958832