Assessment of power spectral density of microvascular hemodynamics in skeletal muscles at very low and low-frequency via near-infrared diffuse optical spectroscopies

Assessment of power spectral density of microvascular hemodynamics in skeletal muscles at very low and low-frequency via near-infrared diffuse optical spectroscopies

In this work, we used a hybrid time domain near-infrared spectroscopy (TD-NIRS) and diffuse correlation spectroscopy (DCS) device to retrieve hemoglobin and blood flow oscillations of skeletal muscle microvasculature. We focused on very low (VLF) and low-frequency (LF) oscillations ( frequency lower...

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Bibliographic Details
Published in:Biomedical optics express Vol. 14; no. 11; p. 5994
Main Authors: Amendola, Caterina, Buttafava, Mauro, Carteano, Talyta, Contini, Letizia, Cortese, Lorenzo, Durduran, Turgut, Frabasile, Lorenzo, Guadagno, Claudia Nunzia, Karadeinz, Umut, Lacerenza, Michele, Mesquida, Jaume, Parsa, Shahrzad, Re, Rebecca, Sanoja Garcia, Diego, Konugolu Venkata Sekar, Sanathana, Spinelli, Lorenzo, Torricelli, Alessandro, Tosi, Alberto, Weigel, Udo M, Yaqub, M Atif, Zanoletti, Marta, Contini, Davide
Format: Journal Article
Language:English
Published: United States 01-11-2023
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Summary:In this work, we used a hybrid time domain near-infrared spectroscopy (TD-NIRS) and diffuse correlation spectroscopy (DCS) device to retrieve hemoglobin and blood flow oscillations of skeletal muscle microvasculature. We focused on very low (VLF) and low-frequency (LF) oscillations ( frequency lower than 0.145 Hz), that are related to myogenic, neurogenic and endothelial activities. We measured power spectral density (PSD) of blood flow and hemoglobin concentration in four muscles (thenar eminence, plantar fascia, sternocleidomastoid and forearm) of 14 healthy volunteers to highlight possible differences in microvascular hemodynamic oscillations. We observed larger PSDs for blood flow compared to hemoglobin concentration, in particular in case of distal muscles ( thenar eminence and plantar fascia). Finally, we compared the PSDs measured on the thenar eminence of healthy subjects with the ones measured on a septic patient in the intensive care unit: lower power in the endothelial-dependent frequency band, and larger power in the myogenic ones were observed in the septic patient, in accordance with previous works based on laser doppler flowmetry.
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ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.502618