Search Results - "Karacosta, Loukia G"

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution by Karacosta, Loukia G., Anchang, Benedict, Ignatiadis, Nikolaos, Kimmey, Samuel C., Benson, Jalen A., Shrager, Joseph B., Tibshirani, Robert, Bendall, Sean C., Plevritis, Sylvia K.

“…Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on…”
Get full text

Phenotyping EMT and MET cellular states in lung cancer patient liquid biopsies at a personalized level using mass cytometry by Karacosta, Loukia G., Pancirer, Danny, Preiss, Jordan S., Benson, Jalen A., Trope, Winston, Shrager, Joseph B., Sung, Arthur Wai, Neal, Joel W., Bendall, Sean C., Wakelee, Heather, Plevritis, Sylvia K.

“…Malignant pleural effusions (MPEs) can be utilized as liquid biopsy for phenotyping malignant cells and for precision immunotherapy, yet MPEs are inadequately…”
Get full text

Phenotypic maps for precision medicine: a promising systems biology tool for assessing therapy response and resistance at a personalized level by Bhattacharyya, Sayantan, Ehsan, Shafqat F, Karacosta, Loukia G

“…In this perspective we discuss how tumor heterogeneity and therapy resistance necessitate a focus on more personalized approaches, prompting a shift toward…”
Get full text

Preclinical Analysis of JAA-F11, a Specific Anti–Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging by Karacosta, Loukia G., Fisk, John C., Jessee, Joseph, Tati, Swetha, Turner, Bradley, Ghazal, Diala, Ludwig, Rachel, Johnson, Holly, Adams, Julia, Sajjad, Munawwar, Koury, Steven, Roy, Rene, Olson, James R., Rittenhouse-Olson, Kate

“…The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been…”
Get full text

Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells by Gocher, Angela M., Azabdaftari, Gissou, Euscher, Lindsey M., Dai, Shuhang, Karacosta, Loukia G., Franke, Thomas F., Edelman, Arthur M.

“…Hyperactivation of Akt is associated with oncogenic changes in the growth, survival, and chemoresistance of cancer cells. The PI3K/phosphoinositide-dependent…”
Get full text

From imaging a single cell to implementing precision medicine: an exciting new era by Karacosta, Loukia G

“…In the age of high-throughput, single-cell biology, single-cell imaging has evolved not only in terms of technological advancements but also in its…”
Get more information

Comparative Effectiveness of Up To Three Lines of Chemotherapy Treatment Plans for Metastatic Colorectal Cancer by Toumazis, Iakovos, Kurt, Murat, Toumazi, Artemis, Karacosta, Loukia G., Kwon, Changhyun

“…Modern chemotherapy agents transformed standard care for metastatic colorectal cancer (mCRC) but raised concerns about the financial burden of the disease. We…”
Get full text

DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity by Anchang, Benedict, Davis, Kara L., Fienberg, Harris G., Williamson, Brian D., Bendall, Sean C., Karacosta, Loukia G., Tibshirani, Robert, Nolan, Garry P., Plevritis, Sylvia K.

“…An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed…”
Get full text

A Regulatory Feedback Loop Between Ca2+/Calmodulin-dependent Protein Kinase Kinase 2 (CaMKK2) and the Androgen Receptor in Prostate Cancer Progression by Karacosta, Loukia G., Foster, Barbara A., Azabdaftari, Gissou, Feliciano, David M., Edelman, Arthur M.

“…The androgen receptor (AR) plays a critical role in prostate cancer (PCa) progression, however, the molecular mechanisms by which the AR regulates cell…”
Get full text

Therapeutic efficacy of the humanized JAA-F11 anti-Thomsen-Friedenreich antibody constructs H2aL2a and H3L3 in human breast and lung cancer xenograft models by Ghazal, Diala, Zalzala, Fatma, Fisk, John C., Tati, Swetha, Karacosta, Loukia G., Morey, Susan, Olson, James R., Quataert, Sally, Dy, Grace K., Rittenhouse-Olson, Kate

Get full text

Nucleoporin 62 and Ca(2+)/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells by Karacosta, Loukia G, Kuroski, Laura A, Hofmann, Wilma A, Azabdaftari, Gissou, Mastri, Michalis, Gocher, Angela M, Dai, Shuhang, Hoste, Allen J, Edelman, Arthur M

“…Re-activation of the transcriptional activity of the androgen receptor (AR) is an important factor mediating progression from androgen-responsive to…”
Get full text

Nucleoporin 62 and Ca2+/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells by Karacosta, Loukia G., Kuroski, Laura A., Hofmann, Wilma A., Azabdaftari, Gissou, Mastri, Michalis, Gocher, Angela M., Dai, Shuhang, Hoste, Allen J., Edelman, Arthur M.

“…BACKGROUND Re‐activation of the transcriptional activity of the androgen receptor (AR) is an important factor mediating progression from androgen‐responsive to…”
Get full text

Abstract 4997: Identifying dynamic EMT states and constructing a proteomic EMT landscape of lung cancer using single cell multidimensional analysis by Karacosta, Loukia G., Anchang, Benedict, Kimmey, Samuel, Rijn, Matt van de, Shrager, Joseph B., Bendall, Sean C., Plevritis, Sylvia K.

“…Abstract The role of EMT in cancer has been well reported and has been shown to prime cells for invasion and metastasis. EMT can be adopted or reversed (i.e…”
Get full text

Abstract PR005: Leveraging mass cytometry for phenotyping CTCs in SCLC liquid biopsies: Tracking therapy resistance at a personalized level by Karacosta, Loukia G, Bhattacharyya, Sayantan, Stewart, Allison, Victorian, Ashley, Lujan, Ester F, Ehsan, Shafqat, Kim, Subin, Duarte, Alberto, Wang, Runsheng, Anchang, Benedict, Wang, Jing, Byers, Lauren

“…Abstract Liquid biopsies present a promising, minimally invasive procedure through which clinicians can assess and monitor disease status by interrogating…”
Get full text

Abstract A033: Leveraging mass cytometry for phenotyping CTCs in SCLC liquid biopsies: Tracking therapy resistance at a personalized level by Karacosta, Loukia G, Bhattacharyya, Sayantan, Stewart, Allison, Victorian, Ashley, Lujan, Ester F, Ehsan, Shafqat, Kim, Subin, Duarte, Alberto, Wang, Runsheng, Anchang, Benedict, Wang, Jing, Byers, Lauren

“…Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR005) of…”
Get full text

Abstract B13: Regulation of Akt activity, cell proliferation, and viability in ovarian cancer cells by calcium/calmodulin-dependent protein kinase kinase 2 by Gocher, Angela M., Franke, Thomas F., Azabdaftari, Gissou, Karacosta, Loukia G., Edelman, Arthur M.

“…Abstract Calcium/Calmodulin-dependent protein kinase kinase 2 (CaMKK2) has been implicated in the regulation of G1/S phase cell cycle progression in prostate…”
Get full text

Abstract 5864: YAP1 defines a highly plastic, persister cell population in small cell lung cancer (SCLC) following relapse by Stewart, C. Allison, Groves, Sarah M., Wang, Runsheng, Ramkumar, Kavya, Xi, Yuanxin, Diao, Lixia, Serrano, Alejandra G., Tanimoto, Azusa, Victorian, Ashley M., Bhattacharyya, Sayantan, Halliday, Alexa J., Kalhor, Neda, Soto, Luisa Maren, Da Rocha, Pedro Filipe, Vokes, Natalie, Karacosta, Loukia G., Wang, Jing, Heymach, John V., Quaranta, Vito, Glisson, Bonnie, Byers, Lauren Averett, Gay, Carl M.

“…Abstract SCLC is an aggressive, neuroendocrine malignancy notable for rapid, albeit transient, responses to therapy. We have previously shown that…”
Get full text

Nucleoporin 62 and Ca super(2+)/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells by Karacosta, Loukia G, Kuroski, Laura A, Hofmann, Wilma A, Azabdaftari, Gissou, Mastri, Michalis, Gocher, Angela M, Dai, Shuhang, Hoste, Allen J, Edelman, Arthur M

“…BACKGROUND Re-activation of the transcriptional activity of the androgen receptor (AR) is an important factor mediating progression from androgen-responsive to…”
Get full text

Nucleoporin 62 and Ca 2+ /calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells by Karacosta, Loukia G., Kuroski, Laura A., Hofmann, Wilma A., Azabdaftari, Gissou, Mastri, Michalis, Gocher, Angela M., Dai, Shuhang, Hoste, Allen J., Edelman, Arthur M.

“…BACKGROUND Re‐activation of the transcriptional activity of the androgen receptor (AR) is an important factor mediating progression from androgen‐responsive to…”
Get full text

Abstract A10: CaMKK2 regulates cellular proliferation and androgen receptor activity during prostate cancer progression by Karacosta, Loukia G., Foster, Barbara A., Gissou, Azabdaftari, Feliciano, David M., Edelman, Arthur M.

“…Abstract Mounting evidence suggests that the androgen receptor (AR) plays a critical role in prostate cancer (PCa) progression. However, the molecular…”
Get full text