Phylogenetic Diversity, Antibiotic Resistance, and Virulence of Escherichia coli Strains from Urinary Tract Infections in Algeria

Phylogenetic Diversity, Antibiotic Resistance, and Virulence of Escherichia coli Strains from Urinary Tract Infections in Algeria

Urinary tract infections (UTIs) caused by represent a significant public health concern due to the high virulence and antimicrobial resistance exhibited by these pathogens. This study aimed to analyze the phylogenetic diversity and antibiotic resistance profiles of Uropathogenic (UPEC) strains isola...

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Bibliographic Details
Published in:Antibiotics (Basel) Vol. 13; no. 8; p. 773
Main Authors: Kara, Anfal, Massaro, Chiara, Giammanco, Giovanni M, Alduina, Rosa, Boussoualim, Naouel
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-08-2024
MDPI
Subjects:
Acids
Age groups
Amoxicillin
Antibiotic resistance
Antibiotics
Antimicrobial resistance
biofilm
Biofilms
Causes of
Drug resistance
Drug resistance in microorganisms
E coli
Escherichia coli
Females
Gender
Genetic aspects
hemolysin
Imipenem
Males
Microbiological research
Multidrug resistance
Nitrofurantoin
phylogenetic groups
Phylogenetics
Phylogeny
Physiological aspects
Piperacillin
Public health
Strains (organisms)
Sulfamethoxazole
Ticarcillin
Trimethoprim
Trimethoprim-sulfamethoxazole
Urinary tract
Urinary tract diseases
Urinary tract infections
Urogenital system
Virulence
Virulence (Microbiology)
Virulence factors
β Lactamase
Algeria
hemolysin
antibiotic resistance
imipenem
Escherichia coli
biofilm
urinary tract infections
phylogenetic groups
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Summary:Urinary tract infections (UTIs) caused by represent a significant public health concern due to the high virulence and antimicrobial resistance exhibited by these pathogens. This study aimed to analyze the phylogenetic diversity and antibiotic resistance profiles of Uropathogenic (UPEC) strains isolated from UTI patients in Algeria, focusing on virulence factors such as extended β-lactamase (ESBL) production, biofilm formation, and hemolytic activity. Phylogenetic grouping of 86 clinical imipenem resistant isolates showed the prevalence of group B2 (48.9%), followed by groups E (22.1%), unknown (12.8%), A (8.1%), and B1 (4.7%), and Clade I, D, Clade I, or Clade II (1.2%). The highest resistance rates were observed towards amoxicillin (86.04%), ticarcillin (82.55%), piperacillin (73.25%), nitrofurantoin (84.88%), and trimethoprim-sulfamethoxazole (51.16%). Notably, 69.8% of UPEC strains were multidrug-resistant (MDR) and 23.2% were extensively drug-resistant (XDR). Additionally, 48.9%, 42%, and 71% of strains demonstrated ESBL production, hemolytic activity, and weak biofilm production, respectively. Continuous monitoring and characterization of UPEC strains are essential to track the spread of the most resistant and virulent phylogenetic groups over time, facilitating rapid therapeutic decisions to treat infections and prevent the emergence of new resistant organisms, helping choose the most effective antibiotics and reducing treatment failure.
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ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics13080773