Search Results - "Karásková, J"

Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis by Kolomietz, Elena, Al-Maghrabi, Jaudah, Brennan, Shawn, Karaskova, Jana, Minkin, Solomon, Lipton, Jeffrey, Squire, Jeremy A.

“…BCR/ABL fluorescent in situ hybridization study of chronic myeloid leukemia (CML) and Philadelphia+(Ph+) acute lymphoid leukemia (ALL) indicated that…”
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Immortal Human Pancreatic Duct Epithelial Cell Lines with Near Normal Genotype and Phenotype by Ouyang, Hong, Mou, Lun-jun, Luk, Catherine, Liu, Ni, Karaskova, Jana, Squire, Jeremy, Tsao, Ming-Sound

“…Immortal epithelial cell lines were previously established after transduction of the HPV16-E6E7 genes into primary cultures of normal pancreatic duct…”
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Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas by HAO DING, RONCARI, Luba, SHANNON, Patrick, XIAOLI WU, LAU, Nelson, KARASKOVA, Jana, GUTMANN, David H, SQUIRE, Jeremy A, NAGY, Andras, GUHA, Abhijit

“…Activation of the p21-ras signaling pathway from aberrantly expressed receptors promotes the growth of malignant human astrocytomas. We developed a transgenic…”
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Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer cell lines by sequential giemsa banding and spectral karyotyping by Beheshti, B, Karaskova, J, Park, P C, Squire, J A, Beatty, B G

“…Currently, prostate cancer (CaP) cytogenetics is not well defined, largely because of technical difficulties in obtaining primary tumor metaphases. We examined…”
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A role for Brca1 in chromosome end maintenance by McPherson, J. Peter, Hande, M. Prakash, Poonepalli, Anuradha, Lemmers, Benedicte, Zablocki, Elzbieta, Migon, Eva, Shehabeldin, Amro, Porras, Annaliza, Karaskova, Jana, Vukovic, Bisera, Squire, Jeremy, Hakem, Razqallah

“…The role of BRCA1 in breast and ovarian tumor suppression has been primarily ascribed to the maintenance of genome integrity. BRCA1 interacts with components…”
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Chromosomal instability in osteosarcoma and its association with centrosome abnormalities by Al-Romaih, K, Bayani, J, Vorobyova, J, Karaskova, J, Park, P.C, Zielenska, M, Squire, J.A

“…The mechanism that generates the extreme aneuploidy that characterizes osteosarcoma (OS) is poorly understood. In this study, interphase fluorescence in situ…”
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Parallel analysis of sporadic primary ovarian carcinomas by spectral karyotyping, comparative genomic hybridization, and expression microarrays by BAYANI, Jane, BRENTON, James D, ZANKE, Brent, SQUIRE, Jeremy A, MACGREGOR, Pascale F, BEHESHTI, Ben, ALBERT, Monique, NALLAINATHAN, Dhani, KARASKOVA, Jana, ROSEN, Barry, MURPHY, Joan, LAFRAMBOISE, Stephanie

“…Analysis of ovarian carcinomas has shown that karyotypes are often highly abnormal and cannot be identified with certainty by conventional cytogenetic methods…”
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Duration of non-Insulin-dependent diabetes mellitus and the TNF-beta NcoI genotype as predictive factors in proliferative diabetic retinopathy by Kanková, K, Muzík, J, Karásková, J, Beránek, M, Hájek, D, Znojil, V, Vlková, E, Vácha, J

“…The object of the study was to investigate the share of the polymorphisms I/D ACE, endothelin 1 4127G/A and TNF-beta NcoI in the susceptibility to…”
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Importance of GM-CSF for in vitro cytogenetic bone marrow analysis in patients with myelodysplastic syndrome by Karásková, J, Holena, O, Michalová, K

“…The cytogenetic examination of the bone marrow (BM) depends on the presence of sufficient amount of mitoses on slides prepared for analysis. The quantity and…”
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Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas by Bayani, Jane, Zielenska, Maria, Pandita, Ajay, Al-Romaih, Khaldoun, Karaskova, Jana, Harrison, Karen, Bridge, Julia A., Sorensen, Poul, Thorner, Paul, Squire, Jeremy A.

“…Conventional cytogenetic studies have shown that osteosarcomas (OSs) are often highly aneuploid, with a large number of both structural and numerical…”
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Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression by Kotchetkov, Rouslan, Driever, Pablo Hernáiz, Cinatl, Jaroslav, Michaelis, Martin, Karaskova, Jana, Blaheta, Roman, Squire, Jeremy A, Von Deimling, Andreas, Moog, Jussi, Cinatl, Jr, Jindrich

“…Acquisition of P-gp-mediated multidrug-resistance does not always correlate with observed malignant behavior of NB. To characterize alterations accompanying…”
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An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma by Lim, Gloria, Karaskova, Jana, Beheshti, Ben, Vukovic, Bisera, Bayani, Jane, Selvarajah, Shamini, Watson, Spencer K., Lam, Wan L., Zielenska, Maria, Squire, Jeremy A.

“…Osteosarcoma (OS) is characterized by chromosomal instability and high‐copy‐number gene amplification. The breakage–fusion–bridge (BFB) cycle is a…”
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Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: A preclinical model by Kotchetkov, Rouslan, Cinatl, Jaroslav, Blaheta, Roman, Vogel, Jens‐Uwe, Karaskova, Jana, Squire, Jeremy, Hernáiz Driever, Pablo, Klingebiel, Thomas, Cinatl, Jindrich

“…Cytotoxic drug treatment of neuroblastoma often leads to the development of drug resistance and may be associated with increased malignancy. To study the…”
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The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice by Gladdy, Rebecca A., Taylor, Michael D., Williams, Christine J., Grandal, Ildiko, Karaskova, Jana, Squire, Jeremy A., Rutka, James T., Guidos, Cynthia J., Danska, Jayne S.

“…Double-strand DNA breaks (DSB) induce chromosomal translocations and gene amplification in cell culture, but mechanisms by which DSB cause genomic instability…”
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Brca1 required for T cell lineage development but not TCR loci rearrangement by Hakem, Razqallah, Mak, Tak W, Hakem, Anne, McPherson, J. Peter, Shehabeldin, Amro, Zablocki, Elzbieta, Migon, Eva, Duncan, Gordon S, Bouchard, Denis, Wakeham, Andrew, Cheung, Alison, Karaskova, Jana, Sarosi, Ildiko, Squire, Jeremy, Marth, Jamey

“…Brca1 (breast cancerl, early onset) deficiency results in early embryonic lethality. As Brca1 is highly expressed in the T cell lineage, a T cell-specific…”
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Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity by Lefebvre, Louis, Nagy, Andras, Dionne, Nancy, Karaskova, Jana, Squire, Jeremy A

“…Embryonic stem cells offer unprecedented opportunities for random or targeted genome alterations in the mouse. We present here an efficient strategy to create…”
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Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis by CHEUNG, Alison M. Y, PRAKASH HANDE, M, YOU-TEN, Annick, ELIA, Andrew, SQUIRE, Jeremy, BRISTOW, Rob, HAKEM, Razqallah, MAK, Tak W, JALALI, Farid, TSAO, Ming-Sound, SKINNIDER, Brian, HIRAO, Atsushi, MCPHERSON, J. Peter, KARASKOVA, Jana, SUZUKI, Akira, WAKEHAM, Andrew

“…BRCA2 is a breast cancer susceptibility gene of which the product is thought to be involved in monitoring genome integrity and cell cycle progression…”
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Acute monocytic leukemia and multiple abnormalities in a child with duplication of 1q detected by GTG-banding and SKY by Scrideli, Carlos A., Baruffi, Marcelo R., Squire, Jeremy A., Ramos, Ester S., Karaskova, Jana, Heck, Benjamin, Tone, Luiz G.

“…Patients with 1q duplication have demonstrated a wide range of multiple congenital abnormalities. Alterations involving this chromosomal region have being…”
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Molecular cytogenetic analysis of glial tumors using spectral karyotyping and comparative genomic hybridization by Squire, J A, Arab, S, Marrano, P, Bayani, J, Karaskova, J, Taylor, M, Becker, L, Rutka, J, Zielenska, M

“…Glial tumors are the most common tumors of the central nervous system, affecting individuals of all ages. Conventional cytogenetics have been unable to…”
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Combined spectral karyotyping, multicolor banding, and microarray comparative genomic hybridization analysis provides a detailed characterization of complex structural chromosomal rearrangements associated with gene amplification in the osteosarcoma cell line MG-63 by Lim, Gloria, Karaskova, Jana, Vukovic, Bisera, Bayani, Jane, Beheshti, Ben, Bernardini, Marcus, Squire, Jeremy A., Zielenska, Maria

“…The advancement of fluorescence in situ hybridization–based assays has permitted more refined delineation of chromosomal loci involved in complex chromosomal…”
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