Search Results - "Kapus, A."

Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction by HEIJINK, I. H, VAN OOSTERHOUT, A, KAPUS, A

“…Impaired airway epithelial barrier function has emerged as a key factor in the pathogenesis of allergic asthma. We aimed to discern the involvement of the…”
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Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-[kappa]B activation by Ailenberg, M, Di Ciano-Oliveira, C, Szaszi, K, Dan, Q, Rozycki, M, Kapus, A, Rotstein, O D

“…Background and Purpose Dynasore has been used extensively as an inhibitor of clathrin-mediated endocytosis. While studying the role of endocytosis in…”
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Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis‐independent NF‐κB activation by Ailenberg, M, Di Ciano‐Oliveira, C, Szaszi, K, Dan, Q, Rozycki, M, Kapus, A, Rotstein, O D

“…Background and Purpose Dynasore has been used extensively as an inhibitor of clathrin‐mediated endocytosis. While studying the role of endocytosis in…”
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XB130, a tissue-specific adaptor protein that couples the RET PTC oncogenic kinase to PI 3-kinase pathway by Lodyga, M, De Falco, V, Bai, X-h, Kapus, A, Melillo, R M, Santoro, M, Liu, M

“…XB130 is a recently cloned 130 kDa-adaptor protein and Src kinase substrate, structurally similar to actin-filament-associated protein. Here we show that XB130…”
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Osmotic stress and the cytoskeleton: the R(h)ole of Rho GTPases by Di Ciano-Oliveira, C., Thirone, A. C. P., Szászi, K., Kapus, A.

“…Hyperosmotic stress initiates a variety of compensatory and adaptive responses, which either serve to restore near‐normal volume or remodel and reinforce the…”
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Beyond the epithelium: Cadherin function in fibrous connective tissues by El Sayegh, T.Y., Kapus, A., McCulloch, C.A.

“…In fibrous connective tissues, fibroblasts are organized into syncytia, cellular networks that enable matrix remodeling and that are interconnected by…”
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Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation by Kapus, A, Grinstein, S, Wasan, S, Kandasamy, R, Orlowski, J

“…Four distinct isoforms of the mammalian Na+/H+ exchanger (NHE) have been identified by molecular cloning. Three of these (NHE-1, NHE-2, and NHE-3) have been…”
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Hypertonic resuscitation of hemorrhagic shock prevents alveolar macrophage activation by preventing systemic oxidative stress due to gut ischemia/reperfusion by Powers, K.A., Zurawska, J., Szaszi, K., Khadaroo, R.G., Kapus, A., Rotstein, O.D.

“…The gut is a target organ of shock/resuscitation (S/R); however, it also contributes to distant inflammation through the generation of oxidants. S/R with…”
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Cell volume-dependent regulation of L-selectin shedding in neutrophils. A role for p38 mitogen-activated protein kinase by Rizoli, S B, Rotstein, O D, Kapus, A

“…Neutrophil-mediated organ damage is a common feature of many disease states. We previously demonstrated that resuscitation with hypertonic salt solutions…”
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Stilbazulenyl nitrone decreases oxidative stress and reduces lung injury after hemorrhagic shock/resuscitation and LPS by Tawadros, P S, Powers, K A, Yang, I, Becker, D A, Ginsberg, M D, Szaszi, K, Kapus, A, Rotstein, O D

“…Multiorgan failure is a major cause of late morbidity and mortality after trauma. Reactive oxygen species generated during shock/resuscitation contribute to…”
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Arachidonic acid stimulates the plasma membrane H+ conductance of macrophages by KAPUS, A, ROMANEK, R, GRINSTEIN, S

“…When activated, phagocytes undergo a large burst of metabolic acid production. Deleterious cytosolic acidification is prevented by extrusion of H+…”
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Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress by Bianchini, L, Kapus, A, Lukacs, G, Wasan, S, Wakabayashi, S, Pouysségur, J, Yu, F H, Orlowski, J, Grinstein, S

“…Hypertonic activation of NHE1, the ubiquitous Na+/H+ exchanger, plays a central role in cell volume regulation, yet little is known about the underlying…”
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Phorbol 12-myristate 13-acetate activates an electrogenic H+- conducting pathway in the membrane of neutrophils by KAPUS, A, SZASZI, K, LIGETI, E

“…The mode of activation of an H(+)-conducting pathway present in the membrane of neutrophils was investigated. (1) Resting neutrophils released protons through…”
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Proton conductance of the plasma membrane: properties, regulation, and functional role by Lukacs, G L, Kapus, A, Nanda, A, Romanek, R, Grinstein, S

“…H+ conductive pathways have been detected in the plasma membranes of a variety of cell types. The large exquisitely H(+)-selective permeability of the…”
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Concurrent left ventricular pressure-loading improves right ventricular function, remodeling, and molecular signaling in response to pulmonary artery banding by Lee, X A, Raschzok, S, Desjardins, J F, Kanny, O, Kabir, G, Nghiem, L, Kapus, A, Connelly, K A, Friedberg, M K

“…Abstract Background Studies have established the significance of right ventricle (RV) function in individuals with many congenital heart diseases, however the…”
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D52 MOLECULAR INSIGHT INTO PULMONARY HYPERTENSION: Smad3 Contributes To Lung Vascular Remodeling In Pulmonary Arterial Hypertension Via Mrtf Disinhibition: A New Pathomechanism by Zabini, D, Kapus, A, Kuebler, W M

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A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages by KAPUS, A, ROMANEK, R, YI QU, A, ROTSTEIN, O. D, GRINSTEIN, S

“…Phagocytes generate large amounts of metabolic acid during activation. Therefore, the presence of a conductive pathway capable of H+ extrusion has been…”
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Pre–B cell colony–enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis by Jia, Song Hui, Li, Yue, Parodo, Jean, Kapus, Andras, Fan, Lingzhi, Rotstein, Ori D., Marshall, John C.

“…Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally identified as a growth factor for early stage B cells. We show here…”
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Regulation of the electrogenic H+ channel in the plasma membrane of neutrophils: possible role of phospholipase A2, internal and external protons by Kapus, A, Suszták, K, Ligeti, E

“…Possible factors regulating the opening of and the rate of H+ flux through a recently described, Cd(2+)-sensitive, phorbol ester- and arachidonic acid…”
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Measurement of the matrix free Ca2+ concentration in heart mitochondria by entrapped fura-2 and quin2 by Lukács, G L, Kapus, A

“…A method was developed to monitor continuously the matrix free Ca2+ concentration ([Ca2+]m) of heart mitochondria by use of the fluorescent Ca2+ indicators,…”
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