Search Results - "Kapui, Zoltan"

Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic α(2C) receptor by Kurko, Dalma, Kapui, Zoltán, Nagy, József, Lendvai, Balázs, Kolok, Sándor

“…Although G protein-coupled receptors (GPCRs) are traditionally categorized as Gs-, Gq-, or Gi/o-coupled, their signaling is regulated by multiple mechanisms…”
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Interaction of SSR161421, a novel specific adenosine A(3) receptor antagonist with adenosine A(3) receptor agonists both in vitro and in vivo by Mikus, Endre G, Boér, Kinga, Timári, Géza, Urbán-Szabó, Katalin, Kapui, Zoltán, Szeredi, Judit, Gerber, Katalin, Szabó, Tibor, Bátori, Sándor, Finet, Michel, Arányi, Péter, Galzin, Anne-Marie

“…A novel adenosine A(3) receptor antagonist (SSR161421) was characterized by both receptor binding assays and pharmacological tests. Binding studies on cloned…”
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Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening by Szaszkó, Mária, Hajdú, István, Flachner, Beáta, Dobi, Krisztina, Magyar, Csaba, Simon, István, Lőrincz, Zsolt, Kapui, Zoltán, Pázmány, Tamás, Cseh, Sándor, Dormán, György

“…A glutaminyl cyclase (QC) fragment library was in silico selected by disconnection of the structure of known QC inhibitors and by lead-like 2D virtual…”
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The influence of 5-HT2A activity on a 5-HT2C specific in vivo assay used for early identification of multiple acting SERT and 5-HT2C receptor ligands by Éliás, Olivér, Nógrádi, Katalin, Domány, György, Szakács, Zoltán, Kóti, János, Szántay, Csaba, Tarcsay, Ákos, Keserű, György M., Gere, Anikó, Kiss, Béla, Kurkó, Dalma, Kolok, Sándor, Némethy, Zsolt, Kapui, Zoltán, Hellinger, Éva, Vastag, Mónika, Sághy, Katalin, Kedves, Rita, Gyertyán, István

“…[Display omitted] As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the…”
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Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic alpha 2C receptor by Kurko, Dalma, Kapui, Zoltan, Nagy, Jozsef, Lendvai, Balazs, Kolok, Sandor

“…Although G protein-coupled receptors (GPCRs) are traditionally categorized as Gs-, Gq-, or Gi/o-coupled, their signaling is regulated by multiple mechanisms…”
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The influence of 5-HT sub(2A) activity on a 5-HT sub(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT sub(2C) receptor ligands by Elias, Oliver, Nogradi, Katalin, Domany, Gyorgy, Szakacs, Zoltan, Koti, Janos, Szantay, Csaba Jr, Tarcsay, Akos, Keserue, Gyorgy M, Gere, Aniko, Kiss, Bela, Kurko, Dalma, Kolok, Sandor, Nemethy, Zsolt, Kapui, Zoltan, Hellinger, Eva, Vastag, Monika, Saghy, Katalin, Kedves, Rita, Gyertyan, Istvan

“…As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the 5-HT sub(2C)…”
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Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor by Kapui, Zoltan, Varga, Marton, Urban-Szabo, Katalin, Mikus, Endre, Szabo, Tibor, Szeredi, Judit, Batori, Sandor, Finance, Olivier, Aranyi, Peter

“…Human leukocyte elastase (HLE) is a proteinase capable of degrading a variety of proteins. Under normal circumstances, the proteolytic activity of HLE is…”
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A novel orally active inhibitor of HLE by Varga, Márton, Kapui, Zoltán, Bátori, Sándor, Nagy, Lajos T., Vasvári-Debreczy, Lelle, Mikus, Endre, Urbán-Szabó, Katalin, Arányi, Péter

“…Human leukocyte elastase (HLE) is a serine proteinase, capable of degrading a variety of structural matrix proteins. SSR69071…”
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Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic α2C receptor by Kurko, Dalma, Kapui, Zoltán, Nagy, József, Lendvai, Balázs, Kolok, Sándor

“…Highlights • Comparative pharmacology of four α2C -AR related signaling pathways was carried out. • We quantify the level of biased signaling by applying an…”
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Poster #S17 ARE DOPAMINE PARTIAL AGONIST ANTIPSYCHOTICS SIMILAR? PRECLINICAL COMPARISON OF ARIPIPRAZOLE, BIFEPRUNOX AND CARIPRAZINE by Kiss, Béla, Gyertyán, István, Némethy, Zsolt, Sághy, Katalin, Laszy, Judit, Fazekas, Károly, Kolok, Sándor, Kapui, Zoltán

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SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia–reperfusion injury by Bidouard, Jean-Pierre, Duval, Nicole, Kapui, Zoltan, Herbert, Jean-Marc, O'Connor, Stephen E., Janiak, Philip

“…Neutrophil elastase contributes to the severity of cardiac damage following coronary ischemia and reperfusion. We evaluated the effects of…”
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The influence of 5-HT 2A activity on a 5-HT 2C specific in vivo assay used for early identification of multiple acting SERT and 5-HT 2C receptor ligands by Éliás, Olivér, Nógrádi, Katalin, Domány, György, Szakács, Zoltán, Kóti, János, Szántay, Csaba, Tarcsay, Ákos, Keserű, György M., Gere, Anikó, Kiss, Béla, Kurkó, Dalma, Kolok, Sándor, Némethy, Zsolt, Kapui, Zoltán, Hellinger, Éva, Vastag, Mónika, Sághy, Katalin, Kedves, Rita, Gyertyán, István

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Interaction of SSR161421, a novel specific adenosine A3 receptor antagonist with adenosine A3 receptor agonists both in vitro and in vivo by Mikus, Endre G., Boér, Kinga, Timári, Géza, Urbán-Szabó, Katalin, Kapui, Zoltán, Szeredi, Judit, Gerber, Katalin, Szabó, Tibor, Bátori, Sándor, Finet, Michel, Arányi, Péter, Galzin, Anne-Marie

“…A novel adenosine A3 receptor antagonist (SSR161421) was characterized by both receptor binding assays and pharmacological tests. Binding studies on cloned…”
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Novel Small-Molecule Inhibitors of Phosphodiesterase 4 Isoenzyme and Human Leukocyte Elastase in the Treatment of Airway Diseases by Kapui, Zoltán

“…Asthma and chronic obstructive pulmonary disease (COPD) are common, severe inflammatory diseases of the respiratory tract for which there is no efficient…”
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The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands by Éliás, Olivér, Nógrádi, Katalin, Domány, György, Szakács, Zoltán, Kóti, János, Szántay, Jr, Csaba, Tarcsay, Ákos, Keserű, György M, Gere, Anikó, Kiss, Béla, Kurkó, Dalma, Kolok, Sándor, Némethy, Zsolt, Kapui, Zoltán, Hellinger, Éva, Vastag, Mónika, Sághy, Katalin, Kedves, Rita, Gyertyán, István

“…As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the 5-HT2C receptor a…”
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Experimental studies on guanosine 3', 5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs by KAPUI, Z, SCHAEFFER, P, MIKUS, E. G, BORONKAY, E, GYÜRKY, J, HERBERT, J.-M, PASCAL, M

“…The effect of 1-cyclopentyl-3-ethyl-6-(3-ethoxypyrid-4-yl)- 1H-pyrazolo[3,4-d]pyrimidin-4-one (SR 265579), a potent inhibitor of guanosine 3',5'-cyclic…”
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Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]. 2nd communication: investigations on theophylline-like activities by Mikus, E G, Kapui, Z, Korbonits, D, Boér, K, Boronkay, E, Gyürky, J, Révész, J, Lacheretz, F, Pascal, M, Arányi, P

“…CH-13584 (formerly: KHL-8425, 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl], CAS 115779-20-9) is a new xanthine…”
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Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl) methyl]. 3rd communication: examinations on opioid mechanisms and physical drug dependence by Kapui, Z, Mikus, E G, Bence, J, Gerber, K, Boér, K, Korbonits, D, Borsodi, A, Arányi, P

“…CH-13584 (formerly: KHL-8425, 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl], CAS 115779-20-9) showed antitussive effect on…”
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