A brief overview on recent advances in spiro[chromane-2,4′-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research

A brief overview on recent advances in spiro[chromane-2,4′-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research

[Display omitted] •Kabbe multi-component cyclocondensation.•Spiro[chromane-2,4′-piperidine]-4(3H)-one functionalized building units.•Excellent docking profile.•Broad spectrum potent inhibitory activity against variety of pathogen. The spiro[chromane-2,4′-piperidine]-4(3H)-one is an important pharmac...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry Vol. 28; no. 23; p. 115813
Main Authors: Ghatpande, Nitin G., Jadhav, Jagannath S., Kaproormath, Rajshekhar V., Soliman, Mahmoud E., Shaikh, Mahidansha M.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-12-2020
Subjects:
4′-piperidine]-4(3H)-one
Biological activity
Pharmacophores
Spiro[chromane-2
structure activity relationship (SAR)
Spiro[chromane-2
HIV-1
AZZ
BC
structure activity relationship (SAR)
LLE
SAR
4′-piperidine]-4(3H)-one
SPC
HCT-116
Pharmacophores
Pmdck
BACE-1
IC50
sEH
EC50
ED50
TRPM8
11β-HSD1
EETs
ACC
DIBAH
DPPH
DOR
BEI
Biological activity
ADME properties
SCD
CAIs
MTT- 3
PK
ATP
HDAC
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Summary:[Display omitted] •Kabbe multi-component cyclocondensation.•Spiro[chromane-2,4′-piperidine]-4(3H)-one functionalized building units.•Excellent docking profile.•Broad spectrum potent inhibitory activity against variety of pathogen. The spiro[chromane-2,4′-piperidine]-4(3H)-one is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review demonstrated an impressive progress in syntheses of spiro[chromane-2,4′-piperidine]-4(3H)-one-derived compoundsin the recent years and focuses on features of their biological relevance's. The prospects for the development of new biologically active substances containing a spiro[chromane-2,4′-piperidine]-4(3H)-one pharmacophore are analyzed and briefly discussed in terms of its structure, reaction, mechanism, scope and potential utility.
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content type line 23
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2020.115813