Search Results - "Kapples, Kevin J."

Substituted (Pyrroloamino)pyridines:  Potential Agents for the Treatment of Alzheimer's Disease by Davis, Larry, Klein, Joseph T, Kapples, Kevin J, Huger, Francis P, Smith, Craig P, Petko, Wayne W, Cornfeldt, Michael, Effland, Richard C

“…A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition…”
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Synthesis and Structure-Activity Relationship of the Isoindolinyl Benzisoxazolpiperidines as Potent, Selective, and Orally Active Human Dopamine D4 Receptor Antagonists by Hendrix, James A., Shimshock, Stephen J., Shutske, Gregory M., Tomer IV, John D., Kapples, Kevin J., Palermo, Mark G., Corbett, Thomas J. (Roy), Vargas, Hugo M., Kafka, Sharon, Brooks, Karen M., Laws-Ricker, Lynn, Lee, David K. H., de Lannoy, Inez, Bordeleau, Michel, Rizkalla, Geihan, Owolabi, Joshua, Kamboj, Rajender K.

“…A new class of potent dopamine D4 antagonists was discovered with selectivity over dopamine D2 and the α‐1 adrenoceptor. The lead compound was discovered by…”
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9-Amino-1,2,3,4-tetrahydroacridin-1-ols. Synthesis and evaluation as potential Alzheimer's disease therapeutics by Shutske, Gregory M, Pierrat, Frank A, Kapples, Kevin J, Cornfeldt, Michael L, Szewczak, Mark R, Huger, Francis P, Bores, Gina M, Haroutunian, Vahram, Davis, Kenneth L

“…The synthesis of a series of 9-amino-1,2,3,4-tetrahydroacridin-1-ols is reported. These compounds are related to 1,2,3,4-tetrahydro-9-acridinamine (THA,…”
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Synthesis of 1‐alkyl‐2,3‐dihydro‐2‐(4‐pyridinyl)‐1 H ‐isoindoles as potential selective serotonin reuptake inhibitors by Kapples, Kevin J., Shutske, Gregory M.

“…Two 2,3‐dihydro‐2‐(4‐pyridinyl)‐1 H ‐isoindoles 2a,b have been synthesized by the reaction of isoindoline with 4‐chloropyridines. In addition, a number of…”
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Synthesis of 1-alkyl-2,3-dihydro-2-(4-pyridinyl)-1H-isoindoles as potential selective serotonin reuptake inhibitors by Kapples, Kevin J., Shutske, Gregory M.

“…Two 2,3‐dihydro‐2‐(4‐pyridinyl)‐1H‐isoindoles 2a,b have been synthesized by the reaction of isoindoline with 4‐chloropyridines. In addition, a number of…”
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Pyrrolo[2,1-c][1,4]benzoxazepines. 2. Synthesis of 5-phenyl derivatives by Kapples, Kevin J., Effland, Richard C.

“…A series of 5‐phenylpyrrolo[2,1‐c][1,4]benzoxazepines with basic substituents at the 11‐position has been synthesized utilizing a nucleophilic aromatic…”
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A novel synthesis of 3-Amino-1,2-benzisoxazoles - an entry into the isoxazolo[3,4,5-ef][1,4]benzoxazepine ring system by Shutske, Gregory M., Kapples, Kevin J.

“…A novel synthesis of 3‐amino‐1,2‐benzisoxazole (3) from 2‐[(isopropylideneamino)oxy]benzonitrile (2) is described. This methodology was used to synthesize…”
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Aminopyridine carbamic acid esters: synthesis and potential as acetylcholinesterase inhibitors and acetylcholine releasers by Shutske, G M, Tomer, J D, Kapples, K J, Hrib, N J, Jurcak, J G, Bores, G M, Huger, F P, Petko, W, Smith, C P

“…4-Amino-3-pyridyl carbamates (2a-c) were synthesized as potential acetylcholinesterase inhibitors and acetylcholine releasers on the basis of the reported…”
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Synthesis of novel pyrido[3,4-f]pyrrolo[1,2-b][1,2,5]triazepines. A Novel heterocyclic ring system by Effland, Richard C., Davis, Larry, Kapples, Kevin J., Olsen, Gordon E.

“…The synthesis of novel pyrido[3,4‐f]pyrrolo[1,2‐b][1,2,5]triazepines 6–17 is described. Subsequent reactions on the parent system include reduction, Grignard…”
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